Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Radiation Biological Toximetry Using Circulating Cell-Free DNA (cfDNA) for Rapid Radiation/Nuclear Triage
Radiat Res. 2024 Apr 25. doi: 10.1667/RADE-23-00159.1. Online ahead of print.ABSTRACTOptimal triage biodosimetry would include risk stratification within minutes, and it would provide useful triage despite heterogeneous dosimetry, cytokine therapy, mixed radiation quality, race, and age. For regulatory approval, the U.S. Food and Drug Administration (FDA) Biodosimetry Guidance requires suitability for purpose and a validated species-independent mechanism. Circulating cell-free DNA (cfDNA) concentration assays may provide such triage information. To test this hypothesis, cfDNA concentrations were measured in unprocessed mon...
Source: Radiation Research - April 25, 2024 Category: Physics Authors: Paul Okunieff Steven G Swarts Bruce Fenton Stephen B Zhang Zhenhuan Zhang Lori Rice Daohong Zhou France Carrier Lurong Zhang Source Type: research
Reduced intensity versus myeloablative conditioning for MDS: long-term results of an EBMT phase III study (RICMAC)
Bone Marrow Transplantation, Published online: 25 April 2024; doi:10.1038/s41409-024-02282-7Reduced intensity versus myeloablative conditioning for MDS: long-term results of an EBMT phase III study (RICMAC) (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 25, 2024 Category: Hematology Authors: Christian Niederwieser Simona Iacobelli Georg-Nikolaus Franke Linda Koster Marleen van Os Uwe Platzbecker Kai H übel Christof Scheid Lutz Peter M üller Matthias Stelljes Elena Morozova Jakob Passweg Francesco Onida Peter Dreger Riccardo Saccardi Marco L Source Type: research
Intraorbital amphotericin B for mucormycosis in an Allo-HSCT recipient
Bone Marrow Transplantation, Published online: 25 April 2024; doi:10.1038/s41409-024-02287-2Intraorbital amphotericin B for mucormycosis in an Allo-HSCT recipient (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 25, 2024 Category: Hematology Authors: Wyatt Schwartz Adam C. Christiansen Sagar S. Patel Source Type: research
Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation
Bone Marrow Transplantation, Published online: 24 April 2024; doi:10.1038/s41409-024-02288-1Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 24, 2024 Category: Hematology Authors: Yana Davidov Noga Shem-Tov Ronit Yerushalmi Tammy Hod Ziv Ben-Ari Arnon Nagler Avichai Shimoni Ivetta Danylesko Source Type: research
Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis
Bone Marrow Transplantation, Published online: 24 April 2024; doi:10.1038/s41409-024-02292-5Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 24, 2024 Category: Hematology Authors: Weiwei Xu Wencui Chen Jinzhou Guo Liang Zhao Guisheng Ren Xianghua Huang Source Type: research
Correction: Long term results of a prospective multicenter observational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study)
Bone Marrow Transplantation, Published online: 23 April 2024; doi:10.1038/s41409-024-02274-7Correction: Long term results of a prospective multicenter observational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study) (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 23, 2024 Category: Hematology Authors: J ürgen Finke Claudia Schmoor Francis Ayuk Justin Hasenkamp Mareike Verbeek Eva-Maria Wagner Harald Biersack Kerstin Sch äfer-Eckart Dominik Wolf Gernot Stuhler Roland Reibke Christoph Schmid Martin Kaufmann Matthias Eder Hartmut Bertz Olga Grishina Source Type: research
Transcriptome of bone marrow-Derived stem cells reveals new inflammatory mediators related to increased survival in patients with multiple myeloma
Cytokine. 2024 Apr 20;179:156613. doi: 10.1016/j.cyto.2024.156613. Online ahead of print.ABSTRACTAlthough multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem cells obtained from MM patients and compared the clinical outcomes of death and survival six months after bone marrow transplantation. The leukapheresis products of 39 patients with MM eligible for autologous transplantation were collected and analyzed. After extraction, the RNA...
Source: Cytokine - April 21, 2024 Category: Molecular Biology Authors: Stefania Tagliari de Oliveira Renata Binato Geise Ellen Broto Erika Tomie Takakura Leticia Navarro Gordan Ferreira Martins Eliana Abdelhay Carolina Panis Source Type: research
Modulation of lipid profile by secretory phospholipase A2 group IIA: Verification with a transgenic mouse model
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149955. doi: 10.1016/j.bbrc.2024.149955. Online ahead of print.ABSTRACTWe previously demonstrated a positive relation of secretory phospholipase A2 group IIA (sPLA2-IIA) with circulating high-density lipoprotein cholesterol (HDL-C) in patients with coronary artery disease, and sPLA2-IIA increased cholesterol efflux in THP-1 cells through peroxisome proliferator-activated receptor-γ (PPAR-γ)/liver X receptor α/ATP-binding cassette transporter A1 (ABCA1) signaling pathway. The aim of the present study was to examine the role of sPLA2-IIA over-expression on lipid profile in a...
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Ling Liang Jing Song Shisheng Miao Qiang Xie Weihua Li Honglang Huang Dongyan Shen Wei Zhang Source Type: research
Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Atherosclerosis)
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Bull Cancer. 2024 Apr 16:S0007-4551(24)00119-X. doi: 10.1016/j.bulcan.2024.02.013. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonizat...
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Tamim Alsuliman Clotilde Aubrun Jacques Olivier Bay Yves Beguin Camille Bigenwald Eolia Brissot Yves Chalandon Patrice Chevallier Simona Pagliuca L éonardo Magro Micha Srour Source Type: research
