Light deficiency in Apoe-/-mice increases atheroma plaque size and vulnerability by modulating local immunity
This study suggest that therapies based on the local delivery of LIGHT within plaques might therefore prevent immune cell derangement and advanced atherosclerosis.PMID:38336102 | DOI:10.1016/j.bbadis.2024.167052 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 9, 2024 Category: Biochemistry Authors: Gema Hurtado-Genov és Andrea Herrero-Cervera Ángela Vinué Susana Mart ín-Vañó Mar ía Aguilar-Ballester Alida Taberner-Cort és Elena Jim énez-Martí Sergio Mart ínez-Hervás Herminia Gonz ález-Navarro Source Type: research
Richard Szydlo, July 1 1959–December 18 2023
Bone Marrow Transplantation, Published online: 09 February 2024; doi:10.1038/s41409-024-02218-1Richard Szydlo, July 1 1959–December 18 2023 (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 9, 2024 Category: Hematology Authors: Jane F. Apperley Source Type: research
Graft-versus-host-disease prophylaxis with ATG or PTCY in patients with lymphoproliferative disorders undergoing reduced intensity conditioning regimen HCT from one antigen mismatched unrelated donor
Bone Marrow Transplantation, Published online: 08 February 2024; doi:10.1038/s41409-024-02225-2Graft-versus-host-disease prophylaxis with ATG or PTCY in patients with lymphoproliferative disorders undergoing reduced intensity conditioning regimen HCT from one antigen mismatched unrelated donor (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 8, 2024 Category: Hematology Authors: Annalisa Paviglianiti Maud Ngoya Marta Pe ña Ariane Boumendil Zafer G ülbas Fabio Ciceri Francesca Bonifazi Domenico Russo Nathalie Fegueux Friedrich Stolzel Claude Eric Bulabois Gerard Soci é Edouard Forcade Carlo Solano Herv é Finel Stephen Robinson Source Type: research
Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study
Bone Marrow Transplantation, Published online: 08 February 2024; doi:10.1038/s41409-024-02223-4Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 8, 2024 Category: Hematology Authors: Shuhei Kurosawa Yoshimitsu Shimomura Ken Ishiyama Kyoko Fuse Yutaka Shimazu Noriko Doki Naoyuki Uchida Masatsugu Tanaka Satoshi Takahashi Masatoshi Sakurai Hikaru Kobayashi Yuta Katayama Satoru Takada Kazutaka Ozeki Hirohisa Nakamae Fumihiko Ishimaru Yosh Source Type: research
Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study
Bone Marrow Transplantation, Published online: 08 February 2024; doi:10.1038/s41409-024-02226-1Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 8, 2024 Category: Hematology Authors: Olga Moser Maud Ngoya Jacques-Emmanuel Galimard Arnaud Dalissier Jean Hugues Dalle Krzysztof Kalwak Wilhelm W össmann Birgit Burkhardt Marc Bierings Marta Gonzalez-Vicent Luc ía López Corral Karin Mellgren Andishe Attarbaschi Jean Henri Bourhis Kristin Source Type: research
Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression
Bone Marrow Transplantation, Published online: 07 February 2024; doi:10.1038/s41409-024-02219-0Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 7, 2024 Category: Hematology Authors: Barbara Meissner Peter Lang Peter Bader Manfred Hoenig Ingo M üller Roland Meisel Johann Greil Martin G. Sauer Markus Metzler Selim Corbacioglu Birgit Burkhardt Matthias W ölfl Brigitte Strahm Kinan Kafa Oliver Basu Holger N. Lode Bernd Gruhn Holger Car Source Type: research
Late relapse of chronic myeloid leukemia after allogeneic bone marrow transplantation points to KANSARL (KANSL1::ARL17A) alteration: a case report with insights on the molecular landscape
AbstractChronic myeloid leukemia is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome and the consequent BCR::ABL1 oncoprotein. In the era before the introduction of tyrosine kinase inhibitors (TKIs), the only potentially curative treatment was allogeneic hematopoietic stem cell transplantation (HSCT). Here, we present the case of a patient affected by CML who experienced a relapse 20 years after allogeneic HSCT. Following relapse, the patient was treated with imatinib and bosutinib, resulting in a deep molecular response and successfully discontinued treatment. Additional analysi...
Source: Annals of Hematology - February 7, 2024 Category: Hematology Source Type: research
Graft-versus-host disease and impact on relapse in myelofibrosis undergoing hematopoietic stem cell transplantation
Bone Marrow Transplantation, Published online: 06 February 2024; doi:10.1038/s41409-024-02220-7Graft-versus-host disease and impact on relapse in myelofibrosis undergoing hematopoietic stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 6, 2024 Category: Hematology Authors: Sofia Oechsler Nico Gagelmann Christine Wolschke Dietlinde Janson Anita Badbaran Evgeny Klyuchnikov Radwan Massoud Kristin Rathje Johanna Richter Mathias Sch äfersküpper Christian Niederwieser Ameya Kunte Silke Heidenreich Francis Ayuk Nicolaus Kr öger Source Type: research
Cost analysis of patients undergoing allogeneic stem cell transplantation or chimeric antigen receptor T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma from a German healthcare payer perspective
Bone Marrow Transplantation, Published online: 06 February 2024; doi:10.1038/s41409-024-02228-zCost analysis of patients undergoing allogeneic stem cell transplantation or chimeric antigen receptor T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma from a German healthcare payer perspective (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 6, 2024 Category: Hematology Authors: P. Ahmadi S. Ghandili F. Jakobs C. Konnopka A. Morgner-Miehlke N. Kr öger F. Ayuk Source Type: research
The effect of center experience on allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia
Bone Marrow Transplantation, Published online: 06 February 2024; doi:10.1038/s41409-024-02222-5The effect of center experience on allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 6, 2024 Category: Hematology Authors: Masamitsu Yanada Shingo Yano Yachiyo Kuwatsuka Koji Kawamura Takahiro Fukuda Tatsuo Ichinohe Yoshiko Hashii Hideki Goto Koji Kato Fumihiko Ishimaru Atsushi Sato Makoto Onizuka Keitaro Matsuo Yuri Ito Atsumi Yanagisawa Marie Ohbiki Ken Tabuchi Yoshiko Atsu Source Type: research
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders
This study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with telomere biology disorders (TBD). Specifically, this review focuses on clinical management of lung, liver, and bone marrow transplantation in TBD patients.Recent FindingsTBD patients have specific unique biological vulnerabilities such as T cell immunodeficiency, susceptibility to infections, hypersensitivity to chemotherapy and radiation, and cytopenias. Furthermore, multiple organ involvement at diagnosis makes clinical management especially challenging due to higher degree of organ damage, and...
Source: Current Hematologic Malignancy Reports - February 5, 2024 Category: Hematology Source Type: research
Dual T cell depletion for graft versus host disease prevention in peripheral blood haploidentical hematopoietic cell transplantation for adults with hematological malignancies
Bone Marrow Transplantation, Published online: 05 February 2024; doi:10.1038/s41409-024-02216-3Dual T cell depletion for graft versus host disease prevention in peripheral blood haploidentical hematopoietic cell transplantation for adults with hematological malignancies (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 5, 2024 Category: Hematology Authors: Tommy Alfaro Moya Maria Queralt Salas Abel Santos Carreira Eshetu G. Atenafu Arjun Datt Law Wilson Lam Ivan Pasic Dennis (Dong Hwan) Kim Fotios V. Michelis Igor Novitzky Basso Armin Gerbitz Jeffrey Howard Lipton Rajat Kumar Jonas Mattsson Auro Viswabandya Source Type: research
Improved Outcome of Primary Plasma Cell Leukemia in the Current Era with the Use of Novel Agents and Autologous Bone Marrow Transplants —A Single Centre Experience
AbstractPrimary Plasma cell leukemia (pPCL) is an aggressive variant of plasma cell dyscrasias. Diagnostic criteria of plasma cell leukemia were recently updated by international myeloma working group to with more than 5% circulating plasma cells or absolute plasma cell count of more than 500/ µL.We performed a retrospective analysis of patients diagnosed with pPCL in our department from 2017 to 2022. Clinical characteristics including the symptoms at presentation, organomegaly, bony involvement and extramedullary involvement were collected. Laboratory parameters including the biochemistry serum protein electrophoresis, s...
Source: Indian Journal of Hematology and Blood Transfusion - February 5, 2024 Category: Hematology Source Type: research
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders
This study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with telomere biology disorders (TBD). Specifically, this review focuses on clinical management of lung, liver, and bone marrow transplantation in TBD patients.Recent FindingsTBD patients have specific unique biological vulnerabilities such as T cell immunodeficiency, susceptibility to infections, hypersensitivity to chemotherapy and radiation, and cytopenias. Furthermore, multiple organ involvement at diagnosis makes clinical management especially challenging due to higher degree of organ damage, and...
Source: Current Hematologic Malignancy Reports - February 5, 2024 Category: Hematology Source Type: research
Efficacy and Safety in Early application of Ruxolinitib for high-risk: Acute lymphoblastic leukemia to prevent GVHD and recurrence after allogeneic hematopoietic stem cell transplantation
CONCLUSIONS: Our preliminary observations suggest that an early application of ruxolitinib can safely and effectively prevent the occurrence of GVHD after allo-HSCT for the high-risk ALL patients. However, ruxolitinib may have a limited effect on preventing the ALL recurrence of high-risk patients.PMID:38302005 | DOI:10.1016/j.trim.2023.101978 (Source: Transplant Immunology)
Source: Transplant Immunology - February 1, 2024 Category: Transplant Surgery Authors: Qian Cheng Yishu Tang Feiyang Liu Xin Li Dan Fang Source Type: research
