Adipose stem cells control obesity-induced T cell infiltration into adipose tissue
Cell Rep. 2024 Mar 15;43(3):113963. doi: 10.1016/j.celrep.2024.113963. Online ahead of print.ABSTRACTT cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obes...
Source: Cancer Control - March 16, 2024 Category: Cancer & Oncology Authors: Xiyan Liao Qin Zeng Limin Xie Haowei Zhang Wanyu Hu Liuling Xiao Hui Zhou Fanqi Wang Wanqin Xie Jianfeng Song Xiaoxiao Sun Dandan Wang Yujin Ding Yayi Jiao Wuqian Mai Wufuer Aini Xiaoyan Hui Wei Liu Willa A Hsueh Tuo Deng Source Type: research
Long term results of a prospective multicenter obervational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study)
Bone Marrow Transplantation, Published online: 16 March 2024; doi:10.1038/s41409-024-02264-9Long term results of a prospective multicenter obervational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study) (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 16, 2024 Category: Hematology Authors: J ürgen Finke Claudia Schmoor Francis Ayuk Justin Hasenkamp Mareike Verbeek Eva-Maria Wagner Harald Biersack Kerstin Sch äfer-Eckart Dominik Wolf Gernot Stuhler Roland Reibke Christoph Schmid Martin Kaufmann Matthias Eder Hartmut Bertz Olga Grishina Source Type: research
Pulmonary function as a continuum of risk: critical care utilization and survival after allogeneic hematopoietic stem cell transplantation - a multicenter cohort study
Bone Marrow Transplantation, Published online: 16 March 2024; doi:10.1038/s41409-024-02265-8Pulmonary function as a continuum of risk: critical care utilization and survival after allogeneic hematopoietic stem cell transplantation - a multicenter cohort study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 16, 2024 Category: Hematology Authors: Hemang Yadav Svetlana Herasevich Zhenmei Zhang Bradley A. White Mehrdad Hefazi Torghabeh William J. Hogan Philip J. Schulte Alexander S. Niven Ognjen Gajic Source Type: research
Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease
We report the results of five patients with SCD, whereas three with DSA, who underwent an unmanipulated haploidentical stem cell transplantation (Haplo-SCT) after a busulfan-based RT-MAC regimen with PT-Cy. To reduce the risk of engraftment failure, a sequential two courses pharmacological pre-transplant immune suppression (PTIS) phase was added prior to the conditioning regimen. All patients engrafted successfully. The procedure was well tolerated. None of the patients developed acute GVHD, whereas one developed moderate chronic GVHD. After a median follow-up of 5 years (range, 2.2-9), all patients are free of pain with e...
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Sabine F ürst Emmanuelle Bernit Faezeh Legrand Angela Granata Samia Harbi Raynier Devillier Valerio Maisano Benjamin Bouchacourt Thomas Pagliardini Djamel Mokart Claude Lemari é Boris Calmels Christophe Picard Agn ès Basire Borje S Andersson Didier Bla Source Type: research
Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT
Bone Marrow Transplantation, Published online: 15 March 2024; doi:10.1038/s41409-024-02269-4Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 15, 2024 Category: Hematology Authors: Marie Robin Simona Iacobelli Linda Koster Jakob Passweg Daniele Avenoso Keith M. O. Wilson Urpu Salmenniemi Peter Dreger Peter von dem Borne John A. Snowden Stephen Robinson Maria Chiara Finazzi Thomas Schroeder Matthew Collin Matthias Eder Edouard Forcad Source Type: research
Non-Congenital Vaginal Obliteration: Surgical Restoration of Vaginal Patency for GVHD
Genital graft-versus-host disease (GVHD) is a known possible complication of bone marrow transplant (BMT). This condition can lead to vaginal obliteration, affecting sexual performance and quality of life. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - March 15, 2024 Category: OBGYN Authors: Alejandro G ómez-Viso, Alison Weidner, Cassandra Kisby Tags: Video Article Source Type: research
Noncongenital Vaginal Obliteration: Surgical Restoration of Vaginal Patency for GVHD
To provide a brief overview of noncongenital causes of vaginal obliteration and stenosis, discuss a unique case of vaginal agglutination in a patient who developed genital graft-versus-host disease (GVHD) after receiving a bone marrow transplant (BMT), and present the steps of a laparoscopic total hysterectomy and lysis of vaginal adhesions that successfully restored vaginal patency without the need for grafting. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - March 15, 2024 Category: OBGYN Authors: Alejandro G ómez-Viso, Alison Weidner, Cassandra Kisby Tags: Video Article Source Type: research
Treatment pattern and outcomes of re-induction therapy prior to stem cell transplantation in patients with relapsed/refractory multiple myeloma in Germany
Bone Marrow Transplantation, Published online: 14 March 2024; doi:10.1038/s41409-024-02208-3Treatment pattern and outcomes of re-induction therapy prior to stem cell transplantation in patients with relapsed/refractory multiple myeloma in Germany (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 14, 2024 Category: Hematology Authors: Sandra Sauer Monika Engelhardt Karolin Trautmann-Grill Christoph Kimmich Mathias H änel Martin Schmidt-Hieber Hans Salwender Carmen Flossmann Hiltrud Heckmann Franziska Ertel Andrea Friederich Sachin Patel Barbara Thun Marc S. Raab Source Type: research
Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease
Bone Marrow Transplantation, Published online: 14 March 2024; doi:10.1038/s41409-024-02257-8Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 14, 2024 Category: Hematology Authors: Sabine F ürst Emmanuelle Bernit Faezeh Legrand Angela Granata Samia Harbi Raynier Devillier Valerio Maisano Benjamin Bouchacourt Thomas Pagliardini Djamel Mokart Claude Lemari é Boris Calmels Christophe Picard Agn ès Basire Borje S. Andersson Didier Bl Source Type: research
Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome
Bone Marrow Transplantation, Published online: 12 March 2024; doi:10.1038/s41409-024-02236-zLong term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 12, 2024 Category: Hematology Authors: S. L. Morris B. R. Thomas R. Palanicawandar S. Whittaker F. Child M. Wain V. Sim R. Szydlo S. Mangar E. Olavarria S. Lozano Cerrada A. Muzamil E. Kanfer Source Type: research
Successful use of narsoplimab to treat allogeneic transplant-associated thrombotic microangiopathy while maintaining sirolimus
Bone Marrow Transplantation, Published online: 11 March 2024; doi:10.1038/s41409-024-02263-wSuccessful use of narsoplimab to treat allogeneic transplant-associated thrombotic microangiopathy while maintaining sirolimus (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 11, 2024 Category: Hematology Authors: Mohammad Alhomoud Michael Scordo Miguel-Angel Perales Source Type: research
GVHD like skin eruption post-autologous stem cell transplantation
Bone Marrow Transplantation, Published online: 11 March 2024; doi:10.1038/s41409-024-02259-6GVHD like skin eruption post-autologous stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 11, 2024 Category: Hematology Authors: Johnathan Fraebel Silvia Park Rahul Shah Carlos Prieto-Granada Emily F. Mason Salyka Sengsayadeth Wichai Chinratanalab Bipin Savani Reena V. Jayani Adetola Kassim Bhagirathbhai R. Dholaria Tae Kon Kim Source Type: research
Low-risk pneumatosis intestinalis in the pediatric surgical population
ConclusionsHere, we define low-risk PI as that which occurs in children over age 1 who do not have a prior diagnosis of cancer or prior BMT and who do not require ICU admission, vasopressor administration, or urgent surgical intervention. It is likely safe to treat these children with only 3 days of antibiotic therapy and NPO.Level of evidenceLevel III. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 11, 2024 Category: Surgery Source Type: research
Ad-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of A β neuropathology
Brain Behav Immun. 2024 Mar 8:S0889-1591(24)00293-9. doi: 10.1016/j.bbi.2024.03.012. Online ahead of print.ABSTRACTImmune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to the worsening of the disease. The damaging alterations in the peripheral immune system may disrupt the peripheral-central immune crosstalk, implicating the gut microbiota in this complex interaction. The central hypothesis posits that the immune signature inhe...
Source: Brain, Behavior, and Immunity - March 10, 2024 Category: Neurology Authors: Ruth Iban-Arias Eun-Jeong Yang Elizabeth Griggs Ariana Soares Dias Portela Aya Osman Kyle J Trageser Mahadi Shahed Giulio Maria Pasinetti Source Type: research
