An Unusual Case of Colitis in a Bone Marrow Transplant Patient
(Source: Gastroenterology)
Source: Gastroenterology - January 20, 2024 Category: Gastroenterology Authors: Nikita Y. Gupta, Sameer Al Diffalha, Kirk B. Russ Tags: Electronic Gastro Curbside Consult Source Type: research

Cancers, Vol. 16, Pages 418: Detection of Genomic Structural Variations Associated with Drug Sensitivity and Resistance in Acute Leukemia
n Yin Kristiina Vuori Acute leukemia is a particularly problematic collection of hematological cancers, and, while somewhat rare, the survival rate of patients is typically abysmal without bone marrow transplantation. Furthermore, traditional chemotherapies used as standard-of-care for patients cause significant side effects. Understanding the evolution of leukemia to identify novel targets and, therefore, drug treatment regimens is a significant medical need. Genomic rearrangements and other structural variations (SVs) have long been known to be causative and pathogenic in multiple types of cancer, including leukemi...
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Darren Finlay Rabi Murad Karl Hong Joyce Lee Andy Wing Chun Pang Chi-Yu Lai Benjamin Clifford Carol Burian James Mason Alex R. Hastie Jun Yin Kristiina Vuori Tags: Article Source Type: research

Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation
Bone Marrow Transplantation, Published online: 18 January 2024; doi:10.1038/s41409-023-02183-1Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 18, 2024 Category: Hematology Authors: Takeshi Sugio Naoyuki Uchida Kohta Miyawaki Yuju Ohno Tetsuya Eto Yasuo Mori Goichi Yoshimoto Yoshikane Kikushige Yuya Kunisaki Shinichi Mizuno Koji Nagafuji Hiromi Iwasaki Tomohiko Kamimura Ryosuke Ogawa Toshihiro Miyamoto Shuichi Taniguchi Koichi Akashi Source Type: research

The impact of social vulnerability index on survival following autologous stem cell transplant for multiple myeloma
Bone Marrow Transplantation, Published online: 18 January 2024; doi:10.1038/s41409-024-02200-xThe impact of social vulnerability index on survival following autologous stem cell transplant for multiple myeloma (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 18, 2024 Category: Hematology Authors: Kiarash Salafian Christine Mazimba Leonid Volodin Indumathy Varadarajan Asal Pilehvari Wen You Ziyad O. Knio Karen Ballen Source Type: research

Prevalence of IgG antibodies against Malawi polyomavirus in patients with autoimmune diseases and lymphoproliferative disorders subjected to bone marrow transplantation
In this study, to verify the putative association between MWPyV and human diseases, MWPyV seroprevalence was investigated in patients affected by i) lymphoproliferative disorders (LPDs) and ii) immune system disorders, i.e., autoimmune diseases (ADs), and in iii) healthy subjects. An indirect ELISA, employing virus-like particles (VLPs) to detect serum IgG antibodies against MWPyV/HPyV 10, was carried out. The study also revealed the prevalence of another polyomavirus, Merkel cell polyomavirus (MCPyV).ResultsSera from patients with distinct autoimmune diseases (n = 44; mean age 20 years) had a prevalence of MWPyV antibodie...
Source: Frontiers in Immunology - January 17, 2024 Category: Allergy & Immunology Source Type: research

Case report: Immune pressure on hematopoietic stem cells can drastically expand glycosylphosphatidylinositol-deficient clones in paroxysmal nocturnal hemoglobinuria
ConclusionsThe PNH clones that had increased excessively before BMT decreased, but persisted at low percentages for more than four years after the immunoablative conditioning regimen followed by syngeneic BMT. These findings indicate that as opposed to conventional theory, immune pressure on HSCs, which caused BM failure before BMT, was sufficient for PIGA-mutated HSCs to clonally expand to develop PNH. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 15, 2024 Category: Allergy & Immunology Source Type: research

Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study
Bone Marrow Transplantation, Published online: 15 January 2024; doi:10.1038/s41409-024-02197-3Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 15, 2024 Category: Hematology Authors: Akshay Sharma Jacques-Emmanuel Galimard Angharad Pryce Senthil Velan Bhoopalan Arnaud Dalissier Jean-Hugues Dalle Franco Locatelli Charlotte Jubert Oana Mirci-Danicar Vassiliki Kitra-Roussou Yves Bertrand Franca Fagioli Fanny Rialland Alessandra Biffi Rob Source Type: research

EASIX and CPSS Cytogenetics score-based composite risk model for patients with CMML undergoing allogeneic transplant
Bone Marrow Transplantation, Published online: 13 January 2024; doi:10.1038/s41409-023-02184-0EASIX and CPSS Cytogenetics score-based composite risk model for patients with CMML undergoing allogeneic transplant (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 13, 2024 Category: Hematology Authors: Anmol Baranwal Abhishek Mangaonkar Mithun V. Shah Aref Al-Kali Ayalew Tefferi William J. Hogan Mark R. Litzow Mrinal M. Patnaik Hassan B. Alkhateeb Source Type: research

Incidence of cardiovascular disease in healthy Swedish peripheral blood stem cell donors – a nationwide study
Bone Marrow Transplantation, Published online: 11 January 2024; doi:10.1038/s41409-023-02196-wIncidence of cardiovascular disease in healthy Swedish peripheral blood stem cell donors – a nationwide study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 11, 2024 Category: Hematology Authors: Simon Pahnke Hans H ägglund Gunnar Larfors Source Type: research

Influence of the Omicron outbreak on allo-HSCT recipients in China: a single-center short-term observational cohort study
Bone Marrow Transplantation, Published online: 11 January 2024; doi:10.1038/s41409-023-02188-wInfluence of the Omicron outbreak on allo-HSCT recipients in China: a single-center short-term observational cohort study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 11, 2024 Category: Hematology Authors: Zhiyu Zhang Man Qiao Xiebing Bao Jing Lu Jingren Zhang Xueqing Dou Xuefeng He Xiaojin Wu Chengcheng Fu Xiaowen Tang Miao Miao Yue Han Shengli Xue Huiying Qiu Caixia Li Yin Wang Zhengming Jin Depei Wu Su-ning Chen Source Type: research

How adoptive transfer of components of the donor immune system boosts GvL and prevents GvHD in HLA-haploidentical hematopoietic transplantation for acute leukemia
Bone Marrow Transplantation, Published online: 11 January 2024; doi:10.1038/s41409-024-02199-1How adoptive transfer of components of the donor immune system boosts GvL and prevents GvHD in HLA-haploidentical hematopoietic transplantation for acute leukemia (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 11, 2024 Category: Hematology Authors: Andrea Velardi Antonella Mancusi Loredana Ruggeri Antonio Pierini Source Type: research

Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study
Bone Marrow Transplantation, Published online: 11 January 2024; doi:10.1038/s41409-024-02198-2Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 11, 2024 Category: Hematology Authors: Ilan Youngster Adi Eshel Mika Geva Ivetta Danylesko Israel Henig Tsila Zuckerman Shalev Fried Ronit Yerushalmi Noga Shem-Tov Joshua A. Fein David Bomze Avichai Shimoni Omry Koren Roni Shouval Arnon Nagler Source Type: research

Donor specific antibodies (DSA): the only risk factor for primary graft failure?
Bone Marrow Transplantation, Published online: 10 January 2024; doi:10.1038/s41409-023-02163-5Donor specific antibodies (DSA): the only risk factor for primary graft failure? (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 10, 2024 Category: Hematology Authors: Andrea Bacigalupo Source Type: research

Re: Prophylactic versus preemptive modified donor lymphocyte infusion for high-risk acute leukemia after allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study
Bone Marrow Transplantation, Published online: 10 January 2024; doi:10.1038/s41409-023-02186-yRe: Prophylactic versus preemptive modified donor lymphocyte infusion for high-risk acute leukemia after allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 10, 2024 Category: Hematology Authors: Leonardo Javier Arcuri Source Type: research

Allogeneic hematopoietic cell transplantation is equally effective in secondary acute lymphoblastic leukemia (ALL) compared to de-novo ALL—a report from the EBMT registry
Bone Marrow Transplantation, Published online: 09 January 2024; doi:10.1038/s41409-023-02192-0Allogeneic hematopoietic cell transplantation is equally effective in secondary acute lymphoblastic leukemia (ALL) compared to de-novo ALL—a report from the EBMT registry (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - January 9, 2024 Category: Hematology Authors: A. Sadowska-Klasa J. M. Zaucha M. Labopin J. H. Bourhis D. Blaise I. Yakoub-Agha U. Salmenniemi J. Passweg N. Fegueux T. Schroeder S. Giebel E. Brissot F. Ciceri M. Mohty Source Type: research