Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Atherosclerosis)
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Resident Memory T Cells in the Atherosclerotic Lesion Associate With Reduced Macrophage Content and Increased Lesion Stability
CONCLUSIONS: TRM cells, characterized by the expression of CD69 and CD49α, constitute a minor population in atherosclerotic lesions and are associated with increased lesion stability in a Hobit and Blimp-1 knockout mouse model.PMID:38634281 | DOI:10.1161/ATVBAHA.123.320511 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 18, 2024 Category: Cardiology Authors: M J M de Jong M A C Depuydt F H Schaftenaar K Liu D Maters Anouk Wezel Harm J Smeets J Kuiper I Bot K van Gisbergen B Sl ütter Source Type: research
Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Bull Cancer. 2024 Apr 16:S0007-4551(24)00119-X. doi: 10.1016/j.bulcan.2024.02.013. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonizat...
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Tamim Alsuliman Clotilde Aubrun Jacques Olivier Bay Yves Beguin Camille Bigenwald Eolia Brissot Yves Chalandon Patrice Chevallier Simona Pagliuca L éonardo Magro Micha Srour Source Type: research
Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Bull Cancer. 2024 Apr 16:S0007-4551(24)00119-X. doi: 10.1016/j.bulcan.2024.02.013. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonizat...
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Tamim Alsuliman Clotilde Aubrun Jacques Olivier Bay Yves Beguin Camille Bigenwald Eolia Brissot Yves Chalandon Patrice Chevallier Simona Pagliuca L éonardo Magro Micha Srour Source Type: research
Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB
ConclusionsTogether, these results indicate disease markers are present as early as the first two weeks postnatal in this model. Further, this model recapitulates social, sensory and fear-related clinical features. Our study using a mouse model of MPS IIIB provides essential baseline information that will be useful in future evaluations of potential treatments. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - April 17, 2024 Category: Neurology Source Type: research
Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplant. 2024 Apr 16. doi: 10.1038/s41409-024-02273-8. Online ahead of print.NO ABSTRACTPMID:38627451 | DOI:10.1038/s41409-024-02273-8 (Source: Herpes)
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
Viruses, Vol. 16, Pages 619: Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF- & kappa;B/NLRP3 Signaling Pathway
Viruses, Vol. 16, Pages 619: Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF-κB/NLRP3 Signaling Pathway
Viruses doi: 10.3390/v16040619
Authors:
Fei Chen
Zhida Chen
Hui-Ting Wu
Xin-Xiang Chen
Peiqi Zhan
Zheng-Yi Wei
Zizhang Ouyang
Xueyan Jiang
Ao Shen
Min-Hua Luo
Qifa Liu
Yue-Peng Zhou
Aiping Qin
Reactivation and infection with cytomegalovirus (CMV) are frequently observed in recipients of solid organ transplants, bone marrow transplants, and individuals with HIV infection. This presents an increasing risk of allograft rejection, opp...
Source: Viruses - April 16, 2024 Category: Virology Authors: Fei Chen Zhida Chen Hui-Ting Wu Xin-Xiang Chen Peiqi Zhan Zheng-Yi Wei Zizhang Ouyang Xueyan Jiang Ao Shen Min-Hua Luo Qifa Liu Yue-Peng Zhou Aiping Qin Tags: Article Source Type: research
AI in wine and haematology
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02285-4AI in wine and haematology (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Shaun R. McCann Source Type: research
Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02273-8Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M. Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02278-3Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Emily C. Liang Kai Rejeski Teng Fei Aya Albittar Jennifer J. Huang Andrew J. Portuguese Qian Wu Sandeep Raj Marion Subklewe Roni Shouval Jordan Gauthier Source Type: research
Outcomes of allogeneic haematopoietic cell transplantation for myelofibrosis in children and adolescents: the retrospective study of the EBMT Paediatric Diseases WP
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02286-3Outcomes of allogeneic haematopoietic cell transplantation for myelofibrosis in children and adolescents: the retrospective study of the EBMT Paediatric Diseases WP (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Jacek Wachowiak Jacques-Emmanuel Galimard Arnaud Dalissier Rawad Rihani Hawazen AlSaedi Robert F. Wynn Jean-Hugues Dalle R égis Peffault de Latour Petr Sedlacek Adriana Balduzzi Thomas Schroeder Ivana Bodova Marta Gonzalez Vicent Bernd Gruhn Rose-Marie H Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood
Eur J Med Genet. 2024 Apr 15;69:104939. doi: 10.1016/j.ejmg.2024.104939. Online ahead of print.ABSTRACTADH5/ALDH2 deficiency is a rare inherited syndrome characterized by short stature, microcephaly, delayed mental development, and hematopoietic dysfunction and has recently been proposed as a disease paradigm. Acute and severe presentations include aplastic anemia, myelodysplastic syndrome, or leukemia, requiring bone marrow transplantation during childhood. Conversely, non-hematological manifestations may exhibit a prolonged and nonspecific clinical trajectory, with growth failure and developmental delay, most of which ar...
Source: European Journal of Medical Genetics - April 13, 2024 Category: Genetics & Stem Cells Authors: Mio Matsumoto Momoko Oyake Tomoyo Itonaga Miwako Maeda Soichi Suenobu Daichi Sato Yoji Sasahara Hiroyuki Mishima Koh-Ichiro Yoshiura Kenji Ihara Source Type: research
Busulfan plus cyclophosphamide vs. total body irradiation plus cyclophosphamide for allogeneic hematopoietic stem cell transplantation in patients with acute T lymphoblastic leukemia: a large-scale propensity score matching-based study
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02280-9Busulfan plus cyclophosphamide vs. total body irradiation plus cyclophosphamide for allogeneic hematopoietic stem cell transplantation in patients with acute T lymphoblastic leukemia: a large-scale propensity score matching-based study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Yifan Shen Minyuan Liu Danya Shen Mengqian Chu Xuekai Li Xiang Zhang Yi Fan Jia Chen Depei Wu Shaoyan Hu Yang Xu Source Type: research
Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02283-6Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Camila D. Donadel Gil C. De Santis Thiago E. Gon çalves Bruno G. Pires Leonardo C. Palma Flavia Gava Renato Luiz Guerino-Cunha Joana T. B. Faria Gabriela V. A. Silva Luiz Guilherme Darrigo-Junior Giancarlo Fatobene Vanderson Rocha Dimas T. Covas Rodrigo Source Type: research
