GSE223796 Donor regulatory T cells rapidly adapt to recipient tissues to control acute graft-versus-host disease [bulk RNA-seq]
Contributors : David J Dittmar ; Michael RehliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdoptive transfer of donor regulatory T cells (Treg) is a promising treatment option for Graft-versus-Host disease (GvHD), but has not yet found its way into routine clinical practice. To map distinctive properties of protective Treg (generated by either polyclonal or allogeneic in vitro expansion), we followed their fate in recipient organs (spleen, liver, colon) in a prophylactic mouse model of MHC-mismatched bone-marrow transplantation (BMT). Using comprehensive gene expression and T cell...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Risk factors, treatments and outcomes of patients with light chain amyloidosis who relapse after autologous stem cell transplantation
Bone Marrow Transplantation, Published online: 26 December 2023; doi:10.1038/s41409-023-02185-zRisk factors, treatments and outcomes of patients with light chain amyloidosis who relapse after autologous stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 26, 2023 Category: Hematology Authors: Yuanyuan Zhang Jinzhou Guo Wencui Chen Liang Zhao Xianghua Huang Source Type: research
RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation
CONCLUSIONS: These findings indicate that RAGE in inflammatory cells is necessary to mediate stimuli of latent chronic inflammation that cause brain inflammation and cognitive decline, potentially by orchestrating monocyte activation via regulation of PSGL-1 expression. Our results also suggest esRAGE-mediated inflammatory regulation as a potential therapeutic option for cognitive dysfunction in MetS with latent chronic inflammation.PMID:38142917 | DOI:10.1016/j.bbi.2023.12.022 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - December 24, 2023 Category: Neurology Authors: Dasen Ye Akio Miyoshi Tomoe Ushitani Manabu Kadoya Masataka Igeta Kosuke Konishi Takuhito Shoji Koubun Yasuda Shiho Kitaoka Hideshi Yagi Etsushi Kuroda Yasuhiko Yamamoto Jidong Cheng Hidenori Koyama Source Type: research
Role of allogeneic hematopoietic stem cell transplantation in patients with high-risk T-cell lymphoblastic leukaemia/lymphoma: an analysis of clinical outcomes
Bone Marrow Transplantation, Published online: 23 December 2023; doi:10.1038/s41409-023-02182-2Role of allogeneic hematopoietic stem cell transplantation in patients with high-risk T-cell lymphoblastic leukaemia/lymphoma: an analysis of clinical outcomes (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 23, 2023 Category: Hematology Authors: Xiaoting Zhang Yuyang Pang Cong Wei Dan Liang Shaoxin Yang Chong Zhao Rui Huang Lan Deng Source Type: research
Inherited Human BCL10 Deficiencies
AbstractHuman BCL10 deficiency causes combined immunodeficiency with bone marrow transplantation as its only curative option. To date, there are four homozygous mutations described in the literature that were identified in four unrelated patients. Here, we describe a fifth patient with a novel mutation and summarize what we have learned about BCL10 deficiency. Due to the severity of the disease, accurate knowledge of its clinical and immunological characteristics is instrumental for early diagnosis and adequate clinical management of the patients. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - December 22, 2023 Category: Allergy & Immunology Source Type: research
Correction: Effect of pharmacokinetics and pharmacogenomics in adults with allogeneic hematopoietic cell transplantation conditioned with Busulfan
Bone Marrow Transplantation, Published online: 21 December 2023; doi:10.1038/s41409-023-02166-2Correction: Effect of pharmacokinetics and pharmacogenomics in adults with allogeneic hematopoietic cell transplantation conditioned with Busulfan (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 21, 2023 Category: Hematology Authors: Claire Seydoux Chakradhara Rao Satyanarayana Uppugunduri Michael Medinger Tiago Nava Joerg Halter Dominik Heim Yves Chalandon Urs Schanz Gayathri Nair Nathan Cantoni Jakob R. Passweg Marc Ansari Source Type: research
Clinical characteristics, disease trajectories and management of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: a systematic review
ConclusionVEXAS syndrome is a rare disorder affecting predominantly middle-aged men. This is the first systematic review to capture clinical manifestations, genetics and treatment of reported cases. Further studies are needed to optimise treatment and subsequently reduce morbidity and mortality. (Source: Rheumatology International)
Source: Rheumatology International - December 21, 2023 Category: Rheumatology Source Type: research
KyoTox-e score; prediction of post-CAR-T prolonged thrombocytopenia using peripheral blood data before apheresis
Bone Marrow Transplantation, Published online: 19 December 2023; doi:10.1038/s41409-023-02175-1KyoTox-e score; prediction of post-CAR-T prolonged thrombocytopenia using peripheral blood data before apheresis (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 19, 2023 Category: Hematology Authors: Tomoyasu Jo Yasuyuki Arai Toshio Kitawaki Naokazu Nakamura Momoko Nishikori Chisaki Mizumoto Junya Kanda Kouhei Yamashita Miki Nagao Akifumi Takaori-Kondo Source Type: research
Posttransplant cyclophosphamide in unrelated and related peripheral blood stem cell transplantation from HLA-matched and 1 allele mismatched donor
Bone Marrow Transplantation, Published online: 19 December 2023; doi:10.1038/s41409-023-02162-6Posttransplant cyclophosphamide in unrelated and related peripheral blood stem cell transplantation from HLA-matched and 1 allele mismatched donor (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 19, 2023 Category: Hematology Authors: Junichi Sugita Takashi Kuroha Jun Ishikawa Tetsuya Eto Kentaro Fukushima Isao Yokota Koichi Akashi Shuichi Taniguchi Mine Harada Takanori Teshima Source Type: research
Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study
Bone Marrow Transplantation, Published online: 18 December 2023; doi:10.1038/s41409-023-02168-0Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 18, 2023 Category: Hematology Authors: Philip L. McCarthy Kristopher M. Attwood Xiaojun Liu George L. Chen Hans Minderman Amin Alousi Asad Bashey Robert Lowsky David B. Miklos John Hansen Peter Westervelt Gregory Yanik Edmund K. Waller Alan Howard Bruce R. Blazar Paul K. Wallace Ran Reshef Mar Source Type: research
Therapeutic options for large B-cell lymphoma relapsing after CD19-directed CAR T-cell therapy
Bone Marrow Transplantation, Published online: 16 December 2023; doi:10.1038/s41409-023-02176-0Therapeutic options for large B-cell lymphoma relapsing after CD19-directed CAR T-cell therapy (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 16, 2023 Category: Hematology Authors: Samantha El Warrak Mohamed A. Kharfan-Dabaja Madiha Iqbal Mehdi Hamadani Julio Chavez Razan Mohty Source Type: research
Analysis of risk factors for fatal renal complications after allogeneic hematopoietic cell transplantation
Bone Marrow Transplantation, Published online: 16 December 2023; doi:10.1038/s41409-023-02172-4Analysis of risk factors for fatal renal complications after allogeneic hematopoietic cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 16, 2023 Category: Hematology Authors: Ryu Yanagisawa Hiroaki Koyama Kimikazu Yakushijin Naoyuki Uchida Atsushi Jinguji Wataru Takeda Tetsuya Nishida Masatsugu Tanaka Tetsuya Eto Hiroyuki Ohigashi Kazuhiro Ikegame Ken-ichi Matsuoka Yuta Katayama Yoshinobu Kanda Masashi Sawa Toshiro Kawakita Ma Source Type: research
Fighting viruses with viruses? ‘Gene drive’ offers new strategy to beat infections
If your immune system or drugs can’t stop a viral infection, why not pit a virus against itself? That’s the provocative idea several labs are pursuing. They are studying whether deliberately introducing engineered viruses into people infected with their natural relatives can “drive” a foreign gene into those viruses that ultimately wipes out an infection.
No lab has knocked down an infection in animals this way yet, but a group has now shown it’s theoretically possible. These so-called gene drives harness the genome editor CRISPR to perform genetic surgery that speeds the spread of a gene through progeny. S...
Source: Science of Aging Knowledge Environment - December 15, 2023 Category: Geriatrics Source Type: research
James Crawford Biggs 1931–2023
Bone Marrow Transplantation, Published online: 15 December 2023; doi:10.1038/s41409-023-02170-6James Crawford Biggs 1931–2023 (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 15, 2023 Category: Hematology Authors: John Moore Sam Milliken Anthony Dodds David Ma John Snowden Source Type: research
Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma
Bone Marrow Transplantation, Published online: 15 December 2023; doi:10.1038/s41409-023-02156-4Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 15, 2023 Category: Hematology Authors: Koji Kato Takeshi Sugio Takashi Ikeda Kanako Yoshitsugu Kana Miyazaki Junji Suzumiya Go Yamamoto Sung-Won Kim Kazuhiro Ikegame Yasufumi Uehara Yasuo Mori Jun Ishikawa Nobuhiro Hiramoto Tetsuya Eto Hideyuki Nakazawa Hikaru Kobayashi Kentaro Serizawa Makoto Source Type: research
