Cerebral infarction in Beh çet’s syndrome caused by obliterative focal arteritis
We present a case in which cerebral infarction was seen and Behcet ’s syndrome was diagnosed. Following investigation and monitoring, we identified that the cause was a progressive obliterative focal arteritis of the middle cerebral artery. Such an entity has not previously been reported, although similar cases are described which explain the pathophysiology of t he disorder. (Source: Neurological Sciences)
Source: Neurological Sciences - January 18, 2024 Category: Neurology Source Type: research
Plasma-derived exosomal protein SHP2 deficiency induces neutrophil hyperactivation in Behcet's uveitis
In conclusion, we highlighted a pathogenic role of plasma-derived exosomal SHP2 deficiency in facilitating neutrophil activation and suggested that SHP2 might be an immunoprotective factor in BU pathologic process.PMID:38211682 | DOI:10.1016/j.exer.2024.109785 (Source: Experimental Eye Research)
Source: Experimental Eye Research - January 11, 2024 Category: Opthalmology Authors: Jinyu Cai Qingfeng Wang Shiyao Tan Qingyan Jiang Rong Liu Guannan Su Shenglan Yi Peizeng Yang Source Type: research
Proteomic profiling of aqueous humor-derived exosomes in Vogt-Koyanagi-Harada disease and Behcet's uveitis
This study performed the first label-free quantitative proteomics on aqueous humor-derived exosomes from 84 patients with VKH or BU to determine their potential roles. Sixty-five differentially expressed proteins (DEPs) and 40 DEPs were detected in the VKH and BU groups, respectively. GO and KEGG analysis showed that DEPs were mainly enriched in the complement-related pathways. The complement C1q subcomponent subunit B (C1QB) was identified as a key exosomal protein, and its expression was significantly increased by western blotting in both diseases. Additionally, the integrated analysis based on the published scRNA-seq da...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Yinan Zhang Yang Deng Shixiang Jing Guannan Su L I Na Ziqian Huang Wanyun Zhang Zhijun Chen Peizeng Yang Source Type: research
Proteomic profiling of aqueous humor-derived exosomes in Vogt-Koyanagi-Harada disease and Behcet's uveitis
This study performed the first label-free quantitative proteomics on aqueous humor-derived exosomes from 84 patients with VKH or BU to determine their potential roles. Sixty-five differentially expressed proteins (DEPs) and 40 DEPs were detected in the VKH and BU groups, respectively. GO and KEGG analysis showed that DEPs were mainly enriched in the complement-related pathways. The complement C1q subcomponent subunit B (C1QB) was identified as a key exosomal protein, and its expression was significantly increased by western blotting in both diseases. Additionally, the integrated analysis based on the published scRNA-seq da...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Yinan Zhang Yang Deng Shixiang Jing Guannan Su Na Li Ziqian Huang Wanyun Zhang Zhijun Chen Peizeng Yang Source Type: research
4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet ’s Uveitis and Experimental Autoimmune Uveitis
Abstract4-octyl itaconate (4-OI) is an anti-inflammatory metabolite that activates the nuclear-factor-E2-related factor 2 (NRF2) signaling. In the current work, we investigated whether 4-OI could affect the production of proinflammatory cytokines in Behcet ’s uveitis (BU) and experimental autoimmune uveitis (EAU). Peripheral blood mononuclear cells (PBMCs) of active BU patients and healthy individuals within vitro 4-OI treatment were performed to assess the influence of 4-OI on the proinflammatory cytokine production. EAU was induced and used for investigating the influence of 4-OI on the proinflammatory cytokine product...
Source: Inflammation - January 6, 2024 Category: Allergy & Immunology Source Type: research
A case of Beh çet's disease with unusual cardiovascular complications
Two arterial aneurysms complicating Behcet ’s disease. Key Clinical MessageBeh çet's disease should be suspected in young adults who present with heart failure and/or vascular lesions. Cardiac involvement and mesenteric artery aneurysm are rare but should be recognized because of their severity. (Source: Clinical Case Reports)
Source: Clinical Case Reports - December 6, 2023 Category: General Medicine Authors: Rova Malala Fandresena Randrianarisoa,
Lalao Nomenjanahary Rakotonirina,
Mirantosoa Fabiola Ravelonjatovo,
Nofihinina Joharisantatra Andrianjanaka,
Nouraly Habib,
Narindrarimanana Avisoa Randriamihangy Tags: CASE REPORT Source Type: research
Angiographic findings of pulmonary arterial involvement in Behcet's Disease: Do they correlate with symptoms and acute phase response?
CONCLUSION: Our results show that isolated pulmonary thrombosis is the main form of PAI, and isolated pulmonary aneurysm formation is rare in our BD cases. In the presence of pulmonary symptoms with or without increased APRs, involvement of segmental or more proximal parts of pulmonary arteries is most commonly detected. We also observed that PAI may be seen in about one fourth of especially male BD patients without symptoms or increased APR. Our results suggest that BD patients with pulmonary symptoms should be screened by CTPA for PAI, however, further research is needed to clarify the role of routine CTPA screening in a...
Source: Respiratory Care - November 30, 2023 Category: Respiratory Medicine Authors: Aysun Aksoy Derya Kocakaya Ozlem Demircioglu Nuri Cagatay Cimsit Bedrettin Yildizeli Sait Karakurt Haner Direskeneli Fatma Alibaz-Oner Source Type: research
A rarely seen challenging differential diagnosis: Breast ulcer in Behcet's disease
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 30, 2023 Category: Rheumatology Authors: Mustafa Dinler,
Re şit Yıldırım,
Burcu Ceren Uludoğan,
Nazife Şule Yaşar Bilge,
Timuçin Kaşifoğlu Tags: LETTER TO THE EDITOR Source Type: research
Angiographic findings of pulmonary arterial involvement in Behcet's Disease: Do they correlate with symptoms and acute phase response?
In this study, we aimed to describe computed tomography pulmonary angiography (CTPA) findings of pulmonary involvement and its correlation with symptoms and acute phase response in BD. (Source: Respiratory Medicine)
Source: Respiratory Medicine - November 28, 2023 Category: Respiratory Medicine Authors: Aysun Aksoy, Derya Kocakaya, Ozlem Demircioglu, Nuri Cagatay Cimsit, Bedrettin Yildizeli, Sait Karakurt, Haner Direskeneli, Fatma Alibaz-Oner Tags: Original Research Source Type: research
Resuming anti-TNF therapy after development of miliary tuberculosis in Behcet ’s disease-related uveitis: a case report
ConclusionThis case suggests that in patients with BD who have discontinued anti-TNF therapy due to miliary TB, restarting anti-TNF therapy may be a therapeutic option after TB has been treated appropriately with careful monitoring for relapse. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - November 28, 2023 Category: Opthalmology Source Type: research
Surgical intervention and management of Behcet disease with perianal abscess: A case report
Asian J Surg. 2023 Oct 30:S1015-9584(23)01709-8. doi: 10.1016/j.asjsur.2023.10.096. Online ahead of print.NO ABSTRACTPMID:37914641 | DOI:10.1016/j.asjsur.2023.10.096 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 1, 2023 Category: Surgery Authors: Shaorong Pan Wanjin Shao Zeyang Chen Source Type: research
Surgical intervention and management of Behcet disease with perianal abscess: A case report
Asian J Surg. 2023 Oct 30:S1015-9584(23)01709-8. doi: 10.1016/j.asjsur.2023.10.096. Online ahead of print.NO ABSTRACTPMID:37914641 | DOI:10.1016/j.asjsur.2023.10.096 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 1, 2023 Category: Surgery Authors: Shaorong Pan Wanjin Shao Zeyang Chen Source Type: research
Central retinal artery occlusion after spinal surgery: Case report and literature review
CONCLUSION: Central retinal artery occlusion is rarely observed following spinal surgery. The cause was presumed to be compression of the orbit by a horseshoe headrest in a prone position due to an accidental shift in position during surgery. This catastrophic complication, albeit rare, is usually irreversible and thus must be prevented. Proper positioning and vigilance by both the surgeon and the anesthesiologist during surgery are fundamental to ensure that the orbits are not under pressure.PMID:37899591 | DOI:10.1177/11206721231210745 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 30, 2023 Category: Opthalmology Authors: Mohamed Foued Rmili Ahmed Chebil Khaled El Matri Slim Werda Yousra Falfoul Leila El Matri Source Type: research
Central retinal artery occlusion after spinal surgery: Case report and literature review
CONCLUSION: Central retinal artery occlusion is rarely observed following spinal surgery. The cause was presumed to be compression of the orbit by a horseshoe headrest in a prone position due to an accidental shift in position during surgery. This catastrophic complication, albeit rare, is usually irreversible and thus must be prevented. Proper positioning and vigilance by both the surgeon and the anesthesiologist during surgery are fundamental to ensure that the orbits are not under pressure.PMID:37899591 | DOI:10.1177/11206721231210745 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 30, 2023 Category: Opthalmology Authors: Mohamed Foued Rmili Ahmed Chebil Khaled El Matri Slim Werda Yousra Falfoul Leila El Matri Source Type: research
