Diagnosis of Behcet's disease in a young male patient with acute bilateral pulmonary embolism; A case report and literature review
We present a 30-year-old patient who was admitted with pleuritic chest pain, non-massive hemoptysis since 4 days ago and medical history of intermittent genial aphthous lesions, and skin lesions. During our evaluation, he had an S1Q3T3 pattern in the electrocardiogram, a high level of D-dimer, a low level of FDP and fibrinogen along with pulmonary emboli in lobar and segmental branches of the right pulmonary artery and segmental branches of left lower lobe pulmonary artery were detected in his pulmonary CT Angiography. Then, he was positive for HLA-B51. Based on his clinical condition and history of recurrent genital and s...
Source: Respiratory Care - April 8, 2024 Category: Respiratory Medicine Authors: Mohammad Hadi Tajik Jalayeri Mahdi Mazandarani Narges Lashkarbolouk Source Type: research
Diagnosis of Behcet's disease in a young male patient with acute bilateral pulmonary embolism; A case report and literature review
We present a 30-year-old patient who was admitted with pleuritic chest pain, non-massive hemoptysis since 4 days ago and medical history of intermittent genial aphthous lesions, and skin lesions. During our evaluation, he had an S1Q3T3 pattern in the electrocardiogram, a high level of D-dimer, a low level of FDP and fibrinogen along with pulmonary emboli in lobar and segmental branches of the right pulmonary artery and segmental branches of left lower lobe pulmonary artery were detected in his pulmonary CT Angiography. Then, he was positive for HLA-B51. Based on his clinical condition and history of recurrent genital and s...
Source: Respiratory Care - April 8, 2024 Category: Respiratory Medicine Authors: Mohammad Hadi Tajik Jalayeri Mahdi Mazandarani Narges Lashkarbolouk Source Type: research
An immune-related adverse event of Behcet ’s-like syndrome following pembrolizumab treatment
In recent years, the emergence of immunotherapy has renewed therapeutic modality. Different from traditional anti-tumor therapy, immune-related adverse events of skin, gastrointestinal tract, liver, lung, endo... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 5, 2024 Category: Respiratory Medicine Authors: Qiao Chen, Deyu Li, Guifeng Zhang, Jiangming Zhong, Li Lin and Zhenhua Liu Tags: Case Report Source Type: research
A cost-of-illness study of Beh çet syndrome in Italy
ConclusionsThe present study offers a comprehensive overview of the economic consequences imposed by BS in a societal perspective, providing insights into the distribution of the different costs component related to BS, thus helping the development of targeted policies. (Source: The European Journal of Health Economics)
Source: The European Journal of Health Economics - March 27, 2024 Category: Health Management Source Type: research
Deficiency of peripheral CLA < sup > + < /sup > Tregs and clinical relevance in Behcet's syndrome
CONCLUSION: CLA+ Tregs decrease in association with arterial aneurysm in patients with BS. CLA+ Tregs may be a predictor of response to BS treatment.PMID:38515127 | DOI:10.1186/s13075-024-03306-9 (Source: Cell Research)
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Jiachen Li Feng Sun Danxue Zhu Yuke Hou Gong Cheng Ping Wang Xu Jin Wenyan Zhou Xiaolin Sun Zhanguo Li Tian Liu Source Type: research
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet ’s syndrome
Autoimmune responses have been suggested to involvement in patients with Behcet ’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 21, 2024 Category: Rheumatology Authors: Jiachen Li, Feng Sun, Danxue Zhu, Yuke Hou, Gong Cheng, Ping Wang, Xu Jin, Wenyan Zhou, Xiaolin Sun, Zhanguo Li and Tian Liu Tags: Research Source Type: research
The Complexity of Being A20: From Biological Functions to Genetic Associations
AbstractA20, encoded byTNFAIP3, is a critical negative regulator of immune activation. A20 is a ubiquitin editing enzyme with multiple domains, each of which mediates or stabilizes a key ubiquitin modification. A20 targets diverse proteins that are involved in pleiotropic immunologic pathways. The complexity of A20-mediated immunomodulation is illustrated by the varied effects of A20 deletion in different cell types and disease models. Clinically, the importance of A20 is highlighted by its extensive associations with human disease. A20 germline variants are associated with a wide range of inflammatory diseases, while soma...
Source: Journal of Clinical Immunology - March 7, 2024 Category: Allergy & Immunology Source Type: research
Revealing Academic Evolution and Frontier Pattern in the Field of Uveitis Using Bibliometric Analysis, Natural Language Processing, and Machine Learning
CONCLUSION: In this century, a growing number of countries/regions/authors/journals are involved in the uveitis study, promoting the scientific output and thematic evolution. Our pioneering study uncovers the evolving academic trends and frontier patterns in this field using bibliometric analysis and AI algorithms.PMID:38427350 | DOI:10.1080/09273948.2023.2262028 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 1, 2024 Category: Allergy & Immunology Authors: Ao Lu Keyan Li Guannan Su Peizeng Yang Source Type: research
Drug Retention Time of Immunosuppressive Therapy in Behcet's Uveitis
CONCLUSION: Adalimumab's drug retention time was found to be similar to and possibly better than cDMARDs in patients with BU, who often suffer from vision-threatening disease at first presentation.PMID:38412375 | DOI:10.1080/09273948.2024.2315205 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 27, 2024 Category: Allergy & Immunology Authors: Donald Tran Sophie Rogers Lyndell L Lim Source Type: research
Long ‐term efficacy, safety, and cumulative retention rate of antitumor necrosis factor‐alpha treatment for patients with Behcet's uveitis: A systematic review and meta‐analysis
ConclusionsAnti-TNF- α therapy represents an effective treatment for BU patients with favorable safety profile and high drug retention rate and a potential advantage of adalimumab over infliximab in terms of ocular inflammation remission, drug retention, and the incidence of severe infusion or injection reactions. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 25, 2024 Category: Rheumatology Authors: Xin Guan,
Zerui Zhao,
Miaomiao Xin,
Guangtao Xia,
Qingrui Yang,
Min Fu Tags: ORIGINAL ARTICLE Source Type: research
Pseudotumoral neuro-behcet ’s disease: case series and review of literature
ConclusionPT NBD is a rare but life-threatening condition. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - February 23, 2024 Category: Neurology Source Type: research
HLA-B*51 Frequency in Transplant Patients and Donors
CONCLUSIONS: No significant relationship was shown between patients diagnosed with end-stage renal disease and HLA-B*51 positivity. Previous studies support frequency of the HLA-B*51 allele in the control group. Although Behçet disease is known to cause renal vasculitis, HLA-B*51 positivity alone was not associated with vasculitis or inflammation.PMID:38385410 | DOI:10.6002/ect.MESOT2023.P76 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Miray Kavuzlu Bircan Zengel Bilkay Ba ştürk Source Type: research
