Acute Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction Post Influenza: A Viral Pneumonia
We present a case of HSV laryngitis in a 71-year-old female who presented with septic shock, acute renal failure, and acute hypoxic respiratory failure secondary to Influenza A and bacterial pneumonia for which she required intubation. The hospitalization course included extubation failures due to stridor, a positive cuff leak test resulting in an open tracheostomy, and a laryngeal biopsy confirming HSV infection, which was successfully treated with acyclovir.PMID:37872902 | PMC:PMC10590468 | DOI:10.7759/cureus.45742 (Source: Herpes)
Source: Herpes - October 24, 2023 Category: Infectious Diseases Authors: Tyler W Boyd Sachin M Patil Jason Sinclair Dennis Chairman Nguyen Van T Mohammed Alnijoumi Source Type: research
Acute Herpes Simplex Virus Laryngitis Presenting as Airway Obstruction Post Influenza: A Viral Pneumonia
We present a case of HSV laryngitis in a 71-year-old female who presented with septic shock, acute renal failure, and acute hypoxic respiratory failure secondary to Influenza A and bacterial pneumonia for which she required intubation. The hospitalization course included extubation failures due to stridor, a positive cuff leak test resulting in an open tracheostomy, and a laryngeal biopsy confirming HSV infection, which was successfully treated with acyclovir.PMID:37872902 | PMC:PMC10590468 | DOI:10.7759/cureus.45742 (Source: Herpes)
Source: Herpes - October 24, 2023 Category: Infectious Diseases Authors: Tyler W Boyd Sachin M Patil Jason Sinclair Dennis Chairman Nguyen Van T Mohammed Alnijoumi Source Type: research
Evaluation of the BioFire ® FilmArray® Pneumonia < em > plus < /em > Panel for Detecting Bacterial Etiological Agents of Lower Respiratory Tract Infections in an Oncologic Hospital. Comparison with Conventional Culture Method
Pol J Microbiol. 2023 Oct 10. doi: 10.33073/pjm-2023-035. Online ahead of print.ABSTRACTConventional methods used to determine pneumonia pathogens are characterized by low sensitivity and long turnaround times. Introducing new tests with better parameters in patients at higher risk of infections is highly anticipated. The results of the conventional quantitative culture method (CM) in determining the bacterial etiology of pneumonia were compared with the results of the Pneumonia plus Panel test (PNP; BioFire® Diagnostics, USA) in 79 samples of bronchoalveolar lavage (BAL). Materials were collected from 79 patients with su...
Source: Polish Journal of Microbiology - October 10, 2023 Category: Microbiology Authors: Maria Teresa Szymankiewicz Anna Szczepanska Elzbieta Stefaniuk Source Type: research
Hospital-acquired bacterial pneumonia (HABP) and ventilator- associated bacterial pneumonia (VABP) in Canada:treatment update and the role of new IV antimicrobials
Expert Rev Anti Infect Ther. 2023 Oct 9. doi: 10.1080/14787210.2023.2268287. Online ahead of print.ABSTRACTINTRODUCTION: Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) continue to be common infections causing significant morbidity and mortality worldwide. Timely initiation of empiric antimicrobial therapy is essential. In this paper, we provide a focused expert opinion on the current and potential empiric antimicrobial treatment options in HABP and VABP in Canada influenced by antimicrobial resistance impacting the use of older agents as well as available new intravenous (...
Source: Expert Review of Anti-Infective Therapy - October 9, 2023 Category: Infectious Diseases Authors: Coleman Rotstein Joseph P Lynch George G Zhanel Source Type: research
A multicenter study on the epidemiology of complicated parapneumonic effusion in the era of currently available pneumococcal conjugate vaccines
CONCLUSION: A decreasing time trend in c-PPE cases among children was shown after the introduction of PCV13 in our area. However, serotype 3 is nowadays a common cause of PPE. Hence, continuous surveillance is imperative in order to follow c-PPE epidemiology over time.PMID:37805358 | DOI:10.1016/j.vaccine.2023.10.004 (Source: Vaccine)
Source: Vaccine - October 7, 2023 Category: Allergy & Immunology Authors: Smaragda Papachristidou Vasiliki Lapea Martha Charisi Eleni Kourkouni Dimitra Kousi Athanasia Xirogianni Olga Dedousi Irene Papaconstadopoulos Eirini Eleftheriou Panagiotis Krepis Sophia Pasparaki Georgios Pantalos Anastasios Doudoulakakis Elisavet Bozavo Source Type: research
A multicenter study on the epidemiology of complicated parapneumonic effusion in the era of currently available pneumococcal conjugate vaccines
CONCLUSION: A decreasing time trend in c-PPE cases among children was shown after the introduction of PCV13 in our area. However, serotype 3 is nowadays a common cause of PPE. Hence, continuous surveillance is imperative in order to follow c-PPE epidemiology over time.PMID:37805358 | DOI:10.1016/j.vaccine.2023.10.004 (Source: Vaccine)
Source: Vaccine - October 7, 2023 Category: Allergy & Immunology Authors: Smaragda Papachristidou Vasiliki Lapea Martha Charisi Eleni Kourkouni Dimitra Kousi Athanasia Xirogianni Olga Dedousi Irene Papaconstadopoulos Eirini Eleftheriou Panagiotis Krepis Sophia Pasparaki Georgios Pantalos Anastasios Doudoulakakis Elisavet Bozavo Source Type: research
Opportunistic bacterial, viral and fungal infections of the lung
Respiratory opportunistic infections are a major cause of morbidity and mortality in severely immunocompromised patients, such as those treated with biological therapies, chemotherapy and solid organ or stem cell transplants, and those with haematological malignancy, aplastic anaemia or HIV infection. The type and degree of immune defect dictates the profile of potential opportunistic pathogens; T-cell-mediated defects increase the risk of viral (cytomegalovirus, respiratory viruses) and Pneumocystis jirovecii infections, whereas neutrophil defects are associated with bacterial pneumonia and invasive aspergillosis. (Source: Medicine)
Source: Medicine - October 3, 2023 Category: Internal Medicine Authors: Katharine M. Pates, Jimstan N. Periselneris, Jeremy S. Brown Tags: Pulmonary infection Source Type: research
Compatibility of Omadacycline With Select Parenteral Products in Simulated Y-Site Administration
The objective of this work was to determine the intravenous compatibility of omadacycline with commonly used intravenous fluids and medications using simulated Y-site administration.METHODS: Omadacycline was prepared at concentrations consistent with a maintenance dose (1 mg/mL) and a loading dose (2 mg/mL) with 0.9% sodium chloride according to the prescribing information. Compatibility via simulated Y-site administration was assessed with selected crystalloids (lactated Ringer's solution, magnesium sulfate, and normal saline with potassium chloride) and intravenous medications (bumetanide, furosemide, heparin, and insuli...
Source: Clinical Therapeutics - September 30, 2023 Category: Drugs & Pharmacology Authors: David A Butler Kelly Moolick Donavon McCray Maxwell Gifford Source Type: research
Compatibility of Omadacycline With Select Parenteral Products in Simulated Y-Site Administration
The objective of this work was to determine the intravenous compatibility of omadacycline with commonly used intravenous fluids and medications using simulated Y-site administration.METHODS: Omadacycline was prepared at concentrations consistent with a maintenance dose (1 mg/mL) and a loading dose (2 mg/mL) with 0.9% sodium chloride according to the prescribing information. Compatibility via simulated Y-site administration was assessed with selected crystalloids (lactated Ringer's solution, magnesium sulfate, and normal saline with potassium chloride) and intravenous medications (bumetanide, furosemide, heparin, and insuli...
Source: Clinical Therapeutics - September 30, 2023 Category: Drugs & Pharmacology Authors: David A Butler Kelly Moolick Donavon McCray Maxwell Gifford Source Type: research
Case Report: Omadacycline in the treatment of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in an adolescent patient
Omadacycline is a novel tetracycline antibiotic that exhibits good in vitro antibacterial activity against atypical pathogens such as Mycoplasma pneumoniae. It is approved for the treatment of adults with community-acquired bacterial pneumonia. However, the safety and efficacy of omadacycline in pediatric patients under 18 years of age have not yet been established. In the present paper, we report a case of pediatric community-acquired pneumonia in which initial empirical anti-infective therapy had failed. The patient received empirical anti-infective therapy with azithromycin and other antimicrobial agents upon admission ...
Source: Frontiers in cellular and infection microbiology - September 29, 2023 Category: Microbiology Source Type: research
The potential clinical value of pairing procalcitonin and lung ultrasonography to guide antibiotic therapy in patients with community-acquired pneumonia: a narrative review
Expert Rev Respir Med. 2023 Sep 28:1-9. doi: 10.1080/17476348.2023.2254232. Online ahead of print.ABSTRACTINTRODUCTION: Lower respiratory tract infections (LRTIs) are among the most frequent infections and are prone to inappropriate antibiotic treatments. This results from a limited accuracy of diagnostic tools in identifying bacterial pneumonia. Lung ultrasound (LUS) has excellent sensitivity and specificity in diagnosing pneumonia. Additionally, elevated procalcitonin (PCT) levels correlate with an increased likelihood of bacterial infection. LUS and PCT appear to be complementary in identifying patients with bacterial p...
Source: Expert Review of Respiratory Medicine - September 28, 2023 Category: Respiratory Medicine Authors: C écile Bessat No émie Boillat-Blanco Werner C Albrich Source Type: research
