Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00178.2023. Online ahead of print.ABSTRACTPrimary bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of Methicillin Resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly-sulfated heparan sulfate oligosaccharides (HS) are shed into the airspaces in response to MRSA pneumonia. In vitro...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Evan P Zehr Christopher L Erzen Kaori Oshima Christophe J Langou ët-Astrié Wells B LaRiviere Deling Shi Fuming Zhang Bruce D McCollister Samuel L Windham Alicia N Rizzo Julie A Bastarache Alexander R Horswill Eric P Schmidt Jakub M Kwiecinski James F Co Source Type: research
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00178.2023. Online ahead of print.ABSTRACTPrimary bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of Methicillin Resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly-sulfated heparan sulfate oligosaccharides (HS) are shed into the airspaces in response to MRSA pneumonia. In vitro...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Evan P Zehr Christopher L Erzen Kaori Oshima Christophe J Langou ët-Astrié Wells B LaRiviere Deling Shi Fuming Zhang Bruce D McCollister Samuel L Windham Alicia N Rizzo Julie A Bastarache Alexander R Horswill Eric P Schmidt Jakub M Kwiecinski James F Co Source Type: research
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00178.2023. Online ahead of print.ABSTRACTPrimary bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of Methicillin Resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly-sulfated heparan sulfate oligosaccharides (HS) are shed into the airspaces in response to MRSA pneumonia. In vitro...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Evan P Zehr Christopher L Erzen Kaori Oshima Christophe J Langou ët-Astrié Wells B LaRiviere Deling Shi Fuming Zhang Bruce D McCollister Samuel L Windham Alicia N Rizzo Julie A Bastarache Alexander R Horswill Eric P Schmidt Jakub M Kwiecinski James F Co Source Type: research
7-Year (2015 –21) longitudinal surveillance of lefamulin in vitro activity against bacterial pathogens collected worldwide from patients with respiratory tract infections including pneumonia and characterization of resistance mechanisms
ConclusionsBased on the coverage of the most important CABP pathogens and lacking cross-resistance, lefamulin may represent a valuable empirical treatment option for ambulatory and hospitalized patients with CABP, particularly in settings with high prevalence of resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 19, 2023 Category: Microbiology Source Type: research
The causal relationship between bacterial pneumonia and diabetes: a two-sample mendelian randomization study
Volume 16, Issue 1, December 2024 . (Source: Islets)
Source: Islets - December 14, 2023 Category: Hematology Authors: Songying PanZhongqi ZhangWeiyi Panga The School of Public Health, Guilin Medical University, Guilin, Guangxi, Chinab Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, Guangxi, China Source Type: research
External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children
Conclusion
Discrimination and calibration were good for bacterial pneumonia but poorer for other SBIs. The rule-out thresholds have the potential to reduce unnecessary investigations and antibiotics in this high-risk group. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - December 14, 2023 Category: Pediatrics Authors: Martin, A. J., van der Velden, F. J. S., von Both, U., Tsolia, M. N., Zenz, W., Sagmeister, M., Vermont, C., de Vries, G., Kolberg, L., Lim, E., Pokorn, M., Zavadska, D., Martinon-Torres, F., Rivero-Calle, I., Hagedoorn, N. N., Usuf, E., Schlapbach, L., K Tags: Original research Source Type: research
The causal relationship between bacterial pneumonia and diabetes: a two-sample mendelian randomization study
Volume 16, Issue 1, December 2024 . (Source: Islets)
Source: Islets - December 14, 2023 Category: Hematology Authors: Songying PanZhongqi ZhangWeiyi Panga The School of Public Health, Guilin Medical University, Guilin, Guangxi, Chinab Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, Guangxi, China Source Type: research
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe
Biomaterials. 2023 Dec 5;304:122419. doi: 10.1016/j.biomaterials.2023.122419. Online ahead of print.ABSTRACTBacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluoresce...
Source: Biomaterials - December 10, 2023 Category: Materials Science Authors: Beitong Zhu Xuejian Xing Jungryun Kim Hyeonji Rha Chun Liu Qiang Zhang Lintao Zeng Minhuan Lan Jong Seung Kim Source Type: research
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe
Biomaterials. 2023 Dec 5;304:122419. doi: 10.1016/j.biomaterials.2023.122419. Online ahead of print.ABSTRACTBacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluoresce...
Source: Biomaterials - December 10, 2023 Category: Materials Science Authors: Beitong Zhu Xuejian Xing Jungryun Kim Hyeonji Rha Chun Liu Qiang Zhang Lintao Zeng Minhuan Lan Jong Seung Kim Source Type: research
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe
Biomaterials. 2023 Dec 5;304:122419. doi: 10.1016/j.biomaterials.2023.122419. Online ahead of print.ABSTRACTBacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluoresce...
Source: Biomaterials - December 10, 2023 Category: Materials Science Authors: Beitong Zhu Xuejian Xing Jungryun Kim Hyeonji Rha Chun Liu Qiang Zhang Lintao Zeng Minhuan Lan Jong Seung Kim Source Type: research
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe
Biomaterials. 2023 Dec 5;304:122419. doi: 10.1016/j.biomaterials.2023.122419. Online ahead of print.ABSTRACTBacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluoresce...
Source: Biomaterials - December 10, 2023 Category: Materials Science Authors: Beitong Zhu Xuejian Xing Jungryun Kim Hyeonji Rha Chun Liu Qiang Zhang Lintao Zeng Minhuan Lan Jong Seung Kim Source Type: research
Bacterial etiology, antimicrobial resistance and factors associated with community acquired pneumonia among adult hospitalized patients in Southwest Ethiopia
CONCLUSION: As a result, it is important to regularly monitor the bacterial etiologies and their patterns of resistance. Additionally, sociodemographic and clinical characteristics should all be taken into account while managing patients with pneumonia empirically in this context.PMID:38045716 | PMC:PMC10692968 | DOI:10.18502/ijm.v15i4.13503 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - December 4, 2023 Category: Microbiology Authors: Abdulhakim Mussema Getenet Beyene Esayas Kebede Gudina Dagninet Alelign Tofik Mohammed Solomon Gebre Bawore Abdurezak Mohammed Seid Wondwossen Tadesse Mulatu Gashaw Source Type: research
