Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
A Deep Learning Model for the Diagnosis and Discrimination of Gram-Positive and Gram-Negative Bacterial Pneumonia for Children Using Chest Radiography Images and Clinical Information
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - June 24, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Compositional shifts within the denture-associated bacteriome in pneumonia - an analytical cross-sectional study
Conclusion. Within the limitations of this study, our evidence supports the role of denture acrylic biomaterials as a potential colonization site for putative respiratory pathogens, which may lead to an increased risk of pneumonia in susceptible individuals. These findings support prior observational studies which have found denture-wearers to be at increased risk of respiratory infection. Further research is needed to confirm the sequence of colonization and translocation to examine potential causal relationships.PMID:37341468 | DOI:10.1099/jmm.0.001702 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - June 21, 2023 Category: Microbiology Authors: Joshua A Twigg Ann Smith Clotilde Haury Melanie J Wilson Jonathan Lees Mark Waters David W Williams Source Type: research
