Case report: Diagnosis of Talaromyces marneffei infection in an HIV-negative patient with septic shock and high-titer anti-interferon gamma autoantibodies by metagenomic next-generation sequencing
ConclusionHIV-negative individuals with anti-IFN-γ autoantibodies typically have relapsing, refractory, and fatal infections, such as talaromycosis, which is typically misdiagnosed in the initial course of the disease. This can lead to septic shock. Clinicians should be aware that they may encounter HIV-negative patients with T. marneffei infection in non-endemic areas. Thus, mNGS is an effective technology for detecting T. marneffei infection. Additionally, the detection of anti-IFN-γ autoantibodies in these patients would aid in knowing their susceptibility to fatal infections. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - July 4, 2023 Category: Microbiology Source Type: research
Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample
CONCLUSION: Hospitalizations with severe AIHA that received TPE had higher rates of adverse in-hospital outcomes.PMID:37395043 | DOI:10.1111/trf.17445 (Source: Transfusion)
Source: Transfusion - July 3, 2023 Category: Hematology Authors: Ali Abdelhay Amir A Mahmoud Omar Ammari Rami Dalbah Mouna Reghis Anas Hashem Mouaz Alkasem Mariam Mostafa Source Type: research
Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample
CONCLUSION: Hospitalizations with severe AIHA that received TPE had higher rates of adverse in-hospital outcomes.PMID:37395043 | DOI:10.1111/trf.17445 (Source: Transfusion)
Source: Transfusion - July 3, 2023 Category: Hematology Authors: Ali Abdelhay Amir A Mahmoud Omar Ammari Rami Dalbah Mouna Reghis Anas Hashem Mouaz Alkasem Mariam Mostafa Source Type: research
Ratio of procalcitonin/Simpson ’s dominance index predicted the short-term prognosis of patients with severe bacterial pneumonia
ConclusionThe ratio of PCT/SDI was a more valuable marker in predicting the 28-day prognosis in patients with SBP. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - July 3, 2023 Category: Microbiology Source Type: research
Bacterial Pneumonia is Associated With Myocardial Fibrosis and Left-Ventricular Dysfunction on Convalescent Imaging
Lots of epidemiological data associate pneumonia with new-onset heart failure. The mechanisms are unclear; however, recent animal models have demonstrated pneumococcal invasion of the myocardium, resulting in cardiac fibrosis. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: W. Courtney, A. Rajwani, R. Perera, G. Dwivedi, Y. Lee, G. Hillis, G. Waterer Source Type: research
Neutrophil responsiveness to IL-10 impairs clearance of Streptococcus pneumoniae from the lungs
In this study, we used mice with myeloid cell specific deletion of IL-10R to investigate the cellular targets of IL-10 immune suppression during infection with Streptococcus pneumoniae, the most common bacterial cause of pneumonia. Our findings suggest that IL-10 restricts the neutrophil response to S. pneumoniae, as neutrophil recruitment to the lungs was elevated in myeloid IL-10R deficient mice and neutrophils in the lungs of these mice were more effective at killing S. pneumoniae. Improved killing of S. pneumoniae was associated with increased production of reactive oxygen species (ROS) and serine protease activity in ...
Source: Journal of Leukocyte Biology - June 29, 2023 Category: Hematology Authors: Kadi J Horn Sam Fulte Michael Yang Brian P Lorenz Sarah E Clark Source Type: research
Neutrophil responsiveness to IL-10 impairs clearance of Streptococcus pneumoniae from the lungs
In this study, we used mice with myeloid cell specific deletion of IL-10R to investigate the cellular targets of IL-10 immune suppression during infection with Streptococcus pneumoniae, the most common bacterial cause of pneumonia. Our findings suggest that IL-10 restricts the neutrophil response to S. pneumoniae, as neutrophil recruitment to the lungs was elevated in myeloid IL-10R deficient mice and neutrophils in the lungs of these mice were more effective at killing S. pneumoniae. Improved killing of S. pneumoniae was associated with increased production of reactive oxygen species (ROS) and serine protease activity in ...
Source: Journal of Leukocyte Biology - June 29, 2023 Category: Hematology Authors: Kadi J Horn Sam Fulte Michael Yang Brian P Lorenz Sarah E Clark Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00018.2023. Online ahead of print.ABSTRACTPneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that g-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind GSAP knockout rats were generated. Wild type and knockout rats possessed simil...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Meredith S Gwin Mikhail F Alexeyev Aron M Geurts Ji Young Lee Chun Zhou Xi-Ming Yang Michael V Cohen James M Downey Robert A Barrington Domenico Spadafora Jonathon P Audia Dara W Frank Sarah Voth Viktoriya Pastukh Jessica Bell Linn Ayers Dhananjay T Tambe Source Type: research
