Identification of non-steroidal aromatase inhibitors via in-silico and in-vitro studies
CONCLUSION: STD-NMR-based epitope mapping indicated close proximity of the alkyl chain followed by an aromatic ring with the receptor (aromatase). These compounds were also found to be non-cytotoxic against human fibroblast cells (BJ cells). Thus, the current study has identified new aromatase inhibitors (compounds 4, and 8) for further pre-clinical and clinical research.PMID:37005533 | DOI:10.2174/1573406419666230330082426 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 3, 2023 Category: Chemistry Authors: Humaira Zafar Rabbia Anis Sana Hafeez Atia-Tul Wahab Maria Aqeel Khan Fatima Zehra Basha Innokenity V Maslennikov M Iqbal Choudhary Source Type: research
Adherence to oral anticancer hormonal therapy in breast cancer patients and its relationship with treatment satisfaction: an important insight from a developing country
CONCLUSIONS: The current study revealed a significant association between treatment satisfaction and adherence to oral hormonal therapy. We recommend creating a specialized scale to measure adherence, considering the psychosocial factors that affect hormonal anticancer medication adherence.PMID:36941628 | DOI:10.1186/s12905-023-02276-5 (Source: Cancer Control)
Source: Cancer Control - March 21, 2023 Category: Cancer & Oncology Authors: Amer A Koni Bushra A Suwan Maisa A Nazzal Alaa Sleem Aiman Daifallah Majd Hamed Allah Razan Y Odeh Sa'ed H Zyoud Source Type: research
A novel anastrozole intravaginal ring for endometriosis: pharmacokinetic characteristics and mucosal irritation
Biomed Chromatogr. 2023 Mar 17:e5627. doi: 10.1002/bmc.5627. Online ahead of print.ABSTRACTIn order to achieve the long-term management of endometriosis, a more economical and environmentally friendly material ethylene vinyl acetate (EVA) was used to prepare the intravaginal ring with anastrozole (ATZ). This paper has compared the pharmacokinetic parameters with oral tablets (Aida®) in mini pigs and evaluated the uterine targeted effect and mucosal irritation of the ring. A bioassay method was developed and validated for the determination of ATZ in mini pigs. The determination of ATZ was achieved by LC-MS/MS using terfena...
Source: Biomedical Chromatography : BMC - March 18, 2023 Category: Biomedical Science Authors: Zixia Yang Jian Dong Siyi Wu Bin Ma Meiying Ning Source Type: research
A novel anastrozole intravaginal ring for endometriosis: pharmacokinetic characteristics and mucosal irritation
Biomed Chromatogr. 2023 Mar 17:e5627. doi: 10.1002/bmc.5627. Online ahead of print.ABSTRACTIn order to achieve the long-term management of endometriosis, a more economical and environmentally friendly material ethylene vinyl acetate (EVA) was used to prepare the intravaginal ring with anastrozole (ATZ). This paper has compared the pharmacokinetic parameters with oral tablets (Aida®) in mini pigs and evaluated the uterine targeted effect and mucosal irritation of the ring. A bioassay method was developed and validated for the determination of ATZ in mini pigs. The determination of ATZ was achieved by LC-MS/MS using terfena...
Source: Biomedical Chromatography : BMC - March 18, 2023 Category: Biomedical Science Authors: Zixia Yang Jian Dong Siyi Wu Bin Ma Meiying Ning Source Type: research
A novel anastrozole intravaginal ring for endometriosis: pharmacokinetic characteristics and mucosal irritation
Biomed Chromatogr. 2023 Mar 17:e5627. doi: 10.1002/bmc.5627. Online ahead of print.ABSTRACTIn order to achieve the long-term management of endometriosis, a more economical and environmentally friendly material ethylene vinyl acetate (EVA) was used to prepare the intravaginal ring with anastrozole (ATZ). This paper has compared the pharmacokinetic parameters with oral tablets (Aida®) in mini pigs and evaluated the uterine targeted effect and mucosal irritation of the ring. A bioassay method was developed and validated for the determination of ATZ in mini pigs. The determination of ATZ was achieved by LC-MS/MS using terfena...
Source: Biomedical Chromatography : BMC - March 18, 2023 Category: Biomedical Science Authors: Zixia Yang Jian Dong Siyi Wu Bin Ma Meiying Ning Source Type: research
Molecules, Vol. 28, Pages 2490: Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme
ar Honnavalli
CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance to treatment eventually occurs through the activation of alternative signaling pathways, thus evading the antiproliferative effects of aromatase inhibitors. One of the evasion pathways is Cylin D-CDK4/6-Rb signaling that promotes tumor proliferation and resistance to aromatase inhibitors. There is significant evidence that the sequential inhibition of bot...
Source: Molecules - March 8, 2023 Category: Chemistry Authors: Tenzin Adon Dhivya Shanmugarajan Hissana Ather Shaik Mohammad Asif Ansari Umme Hani SubbaRao V. Madhunapantula Yogish Kumar Honnavalli Tags: Article Source Type: research
Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study
ConclusionSaracatinib did not improve outcomes in post-menopausal women with metastatic breast cancer. There was no observed beneficial effect on bone metastases.CRUKE/11/023, ISRCTN23804370. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 2, 2023 Category: Cancer & Oncology Source Type: research
Case Report: Anastrozole as a monotherapy for pre-pubertal children with non-classic congenital adrenal hyperplasia
We present three pre-pubertal female children with a diagnosis of NC-CAH treated with anastrozole monotherapy after presenting with advanced bone age, early adrenarche, no signs of genital virilization, and normal peak cortisol in response to ACTH stimulation testing. Bone age z-scores normalized, and all three reached or exceeded their target heights. Monotherapy with anastrozole can be an effective alternative in slowing down bone maturation and improving height outcomes in children with NC-CAH and normal adrenal cortisol production. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 2, 2023 Category: Endocrinology Source Type: research
ASO Visual Abstract: Local-Regional Recurrence Following Neoadjuvant Endocrine Therapy - Data from ACOSOG Z1031 (Alliance), a Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor-Positive Clinical Stage 2-3 Breast Cancer
Ann Surg Oncol. 2023 Feb 6. doi: 10.1245/s10434-023-13149-4. Online ahead of print.NO ABSTRACTPMID:36745260 | DOI:10.1245/s10434-023-13149-4 (Source: Ann Oncol)
Source: Ann Oncol - February 6, 2023 Category: Cancer & Oncology Authors: Kelly K Hunt Vera J Suman Hannah F Wingate A Marilyn Leitch Gary Unzeitig Judy C Boughey Funda Meric-Bernstam Matthew J Ellis John A Olson Source Type: research
ASO Visual Abstract: Local-Regional Recurrence Following Neoadjuvant Endocrine Therapy - Data from ACOSOG Z1031 (Alliance), a Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor-Positive Clinical Stage 2-3 Breast Cancer
Ann Surg Oncol. 2023 Feb 6. doi: 10.1245/s10434-023-13149-4. Online ahead of print.NO ABSTRACTPMID:36745260 | DOI:10.1245/s10434-023-13149-4 (Source: Ann Oncol)
Source: Ann Oncol - February 6, 2023 Category: Cancer & Oncology Authors: Kelly K Hunt Vera J Suman Hannah F Wingate A Marilyn Leitch Gary Unzeitig Judy C Boughey Funda Meric-Bernstam Matthew J Ellis John A Olson Source Type: research
First use of antineoplastic agents in women with breast cancer in the state of Rio de Janeiro, Brazil
Conclusion: The findings point to important bottlenecks and possible inequities in access to treatment and medicine utilization for breast cancer patients in Brazil. Efforts to improve breast cancer treatment and prevention should not only focus on interventions at the individual level but address the disease as a public health problem. The study focused on women undergoing their first round of treatment, providing valuable insight into patient and treatment characteristics to inform policy decisions. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 6, 2023 Category: Drugs & Pharmacology Source Type: research
Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer
ConclusionsPatients who initiated with tamoxifen had a steeper decrease in adherence over the 5 years compared with anastrozole, letrozole, and exemestane groups. Furthermore, higher adherence was associated with a decreased risk of mortality. Physicians should be cognizant of decreasing adherence over time and choose effective treatment options with minimal side-effect profiles to better su pport adherence by patients with breast cancer. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 6, 2023 Category: Drugs & Pharmacology Source Type: research
ASO Visual Abstract: Local-Regional Recurrence Following Neoadjuvant Endocrine Therapy – Data from ACOSOG Z1031 (Alliance), a Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor–Positive Clinical Stage 2–3 Breast Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 6, 2023 Category: Cancer & Oncology Source Type: research
Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer
CONCLUSIONS: Patients who initiated with tamoxifen had a steeper decrease in adherence over the 5 years compared with anastrozole, letrozole, and exemestane groups. Furthermore, higher adherence was associated with a decreased risk of mortality. Physicians should be cognizant of decreasing adherence over time and choose effective treatment options with minimal side-effect profiles to better support adherence by patients with breast cancer.PMID:36740664 | DOI:10.1007/s40261-023-01247-w (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 5, 2023 Category: Cancer & Oncology Authors: Chanhyun Park Ji-Haeng Heo Sanica Mehta Sola Han Jennifer C Spencer Source Type: research
Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer
CONCLUSIONS: Patients who initiated with tamoxifen had a steeper decrease in adherence over the 5 years compared with anastrozole, letrozole, and exemestane groups. Furthermore, higher adherence was associated with a decreased risk of mortality. Physicians should be cognizant of decreasing adherence over time and choose effective treatment options with minimal side-effect profiles to better support adherence by patients with breast cancer.PMID:36740664 | DOI:10.1007/s40261-023-01247-w (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 5, 2023 Category: Cancer & Oncology Authors: Chanhyun Park Ji-Haeng Heo Sanica Mehta Sola Han Jennifer C Spencer Source Type: research
