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Treatment patterns and clinical outcomes in patients with metastatic breast cancer treated with palbociclib-based therapies: real-world data in the Han population
CONCLUSIONS: Various palbociclib-based regimens have promising efficacy in ER+ metastatic breast cancer in real-world settings, even in patients who had been pre-treated with everolimus.PMID:35984107 | DOI:10.1097/CM9.0000000000002240 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - August 19, 2022 Category: General Medicine Authors: Hongnan Mo Fei Ma Qing Li Pin Zhang Peng Yuan Jiayu Wang Yang Luo Ruigang Cai Qiao Li Binghe Xu Source Type: research

Modelling the procoagulatory effect of Anastrozole relative to ER α and ERβ expression in breast cancer cells
ConclusionThese results provide basic science evidence showing that the hypercoagulatory effects induced by Anastrozole treatment may be related to the tumour subphenotype. Clinical studies are required to determine whether tracking of hypercoagulatory parameters may hold value in describing subphenotypic alterations or metastatic potential during tumour progression. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - August 6, 2022 Category: Hematology Source Type: research

Aromatase Inhibition Increases Blood Pressure and Markers of Renal Injury in Female Rats
In conclusion, chronic aromatase inhibition in vivo with ASZ increases blood pressure and markers of renal proximal tubular injury in female Sprague Dawley rats, suggesting an important role for aromatization in the maintenance cardiovascular and renal health in females.PMID:35900340 | DOI:10.1152/ajprenal.00055.2022 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - July 28, 2022 Category: Physiology Authors: Rawan N Almutlaq Annie E Newell-Fugate Louise Christine Evans Huma Fatima Eman Y Gohar Source Type: research

Metachronous bilateral breast cancer diagnosed with primary breast lymphoma and mucinous carcinoma: The first case in the literature
CONCLUSIONS: The evaluation of unilateral breast cancer patients in terms of bilateral breast cancer occurrence risk has become important.PMID:35900573 | DOI:10.4103/jcrt.JCRT_1008_20 (Source: Cell Research)
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Melih Simsek Fatma Aykas Ahmet Ozgen Yildirim Source Type: research

Aromatase Inhibition Increases Blood Pressure and Markers of Renal Injury in Female Rats
In conclusion, chronic aromatase inhibition in vivo with ASZ increases blood pressure and markers of renal proximal tubular injury in female Sprague Dawley rats, suggesting an important role for aromatization in the maintenance cardiovascular and renal health in females.PMID:35900340 | DOI:10.1152/ajprenal.00055.2022 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 28, 2022 Category: Urology & Nephrology Authors: Rawan N Almutlaq Annie E Newell-Fugate Louise Christine Evans Huma Fatima Eman Y Gohar Source Type: research