Metachronous bilateral breast cancer diagnosed with primary breast lymphoma and mucinous carcinoma: The first case in the literature
Conclusions: The evaluation of unilateral breast cancer patients in terms of bilateral breast cancer occurrence risk has become important. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - July 25, 2022 Category: Cancer & Oncology Authors: Melih Simsek Fatma Aykas Ahmet Ozgen Yildirim Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Doping with aromatase inhibitors and oestrogen receptor modulators in steroid users: Analysis of a forum to identify dosages, durations and adverse drug reactions
CONCLUSIONS: Patient narratives posted on forums can be a useful tool in the context of doping, to better understand practices, motivations and possibly to bring up pharmacovigilance signals.PMID:35660259 | DOI:10.1016/j.therap.2022.03.004 (Source: Therapie)
Source: Therapie - June 6, 2022 Category: Psychiatry & Psychology Authors: Micha ël Rochoy Antoine Danel Emmanuel Chazard Sophie Gautier Christophe Berkhout Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Cancer Control - June 3, 2022 Category: Cancer & Oncology Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Cancer Control - June 3, 2022 Category: Cancer & Oncology Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
Anastrozole and Related Glucuronic Acid Conjugate are Electrophilic Species
Xenobiotica. 2022 Jun 3:1-12. doi: 10.1080/00498254.2022.2086503. Online ahead of print.ABSTRACTAnastrozole (ANA), is an inhibitor of non-steroidal aromatase, widely employed for the treatment of breast cancer. However, ANA-associated liver injury cases have been documented in the application of the drug.The major purposes of the present study were to identify the structure of reactive metabolites derived from ANA and to study related metabolic pathways of ANA.We found ANA itself is an electrophilic species reactive to GSH. ANA can be metabolized to ANA-N+-glucuronide (1) catalyzed by UGT1A4. An ANA GSH conjugate (2) was d...
Source: Xenobiotica - June 3, 2022 Category: Research Authors: Siyu Ding Siyu Liu Yaxuan Chen Ying Peng Jiang Zheng Source Type: research
