Infection may play an important role in the pathogenesis of alveolar osteonecrosis following facial herpes zoster: a case report and literature review
CONCLUSIONS: The coexistence of bacterial and viral infection may play an important role in the pathogenesis of alveolar osteonecrosis following HZ. To our knowledge, we are the first to directly explore microbial pathogens in a case of postherpetic alveolar osteonecrosis through next-generation sequencing and bacterial culture. We recommend that oral examinations be carefully conducted for patients who are diagnosed with facial HZ, even if their facial rashes have faded away. We suggest that a prolonged and full-dose antiviral therapy course may be beneficial for the treatment of facial HZ with intraoral lesions. The impl...
Source: Herpes - April 2, 2024 Category: Infectious Diseases Authors: Kaikai Huang Youyuan Wang Yuhua Huang Shanshan Han Yu Yang Pinghua Qu Baoying Liang Qingyu Zhen Wenting Chen Ying Lin Source Type: research
Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments
ConclusionDuring the 5 years of long-term antiviral treatment, liver fibrosis rapidly regresses in the first 1.5 years before slowing down in the following 3.5 years.Graphical Abstract (Source: Hepatology International)
Source: Hepatology International - April 2, 2024 Category: Infectious Diseases Source Type: research
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study
CONCLUSION: CMV positivity was associated with worse outcomes of need for rescue therapy, hospital stay and readmissions. Antiviral therapy was not found to reduce the risk of colectomy but did extend the time to colectomy. Further prospective studies will be required to more clearly determine its benefit in patients with concomitant CMV and ASUC.PMID:38560721 | PMC:PMC10981253 | DOI:10.1177/20406223241233203 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Dazhong Huang Michael Rennie Alicia Krasovec Shyam Nagubandi Sichang Liu Edward Ge Barinder Khehra Michael Au Shobini Sivagnanam Vu Kwan Claudia Rogge Nikola Mitrev Viraj Kariyawasam Source Type: research
CB ‐0821, a novel CC chemokine receptor 5 (CCR5) inhibitor with improved binding efficacy proposed as anti‐HIV candidate: Computational and in vitro approach
In this study, CB-0821, identified from the ChemBridge library, emerged as a promising CCR5 inhibitor. Molecular dynamics simulations indicate comparable dynamic properties for CB-0821 and MVC. In silico comparisons with other CCR5 inhibitors emphasize CB-0821's superior binding affinity, positioning it as a potential lead compound. Evaluations of the dissociation constant (Ki) and absorption, distribution, metabolism, and excretion predictions suggest CB-0821 as a well-tolerated drug. Furthermore, the dose-dependent inhibition of CCR5 by CB-0821 in Peripheral blood mononuclear cells (PBMCs) (ranging from 10 to 200 nM) d...
Source: Biotechnology and Applied Biochemistry - April 1, 2024 Category: Biochemistry Authors: Ashish Kumar Tags: ORIGINAL ARTICLE Source Type: research
Intermediate Term Outcomes of CAV Screening in Heart Transplant Recipients from Hepatitis C Viremic Donors versus Non-Hepatitis C Donors
We report 5-year outcomes from routine annual CAV screening by intravascular ultrasound (IVUS) in HCV-viremic donors [nucleic amplification test: NAT (+)] vs non-viremic donors: NAT (-). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Birs, E. Adler, K. Hong, S. Aslam, N. Wettersten Source Type: research
Viruses, Vol. 16, Pages 529: Quantitative Measurement of Serum HBcrAg Can Be Used to Assess the Feasibility of Safe Discontinuation of Antiviral Therapy for Chronic Hepatitis B
Chen
Hepatitis B virus (HBV) infection is a serious global health problem, and chronic HBV infection significantly increases the risk of liver fibrosis, cirrhosis, and even hepatocellular carcinoma in patients. Current first-line therapeutics such as nucleos(t)ide analogues and interferons are unable to completely clear cccDNA, so the vast majority of patients need to take long-term or even lifelong medication. However, long-term virological and biochemical responses can be achieved in some patients after drug withdrawal. Successfully screening these patients with drug withdrawal advantages is difficult. Hepatitis-B-c...
Source: Viruses - March 29, 2024 Category: Virology Authors: Yong-Hong Wang Hong Tang En-Qiang Chen Tags: Review Source Type: research
Herpes zoster in neuro-ophthalmology: a practical approach
Eye (Lond). 2024 Mar 27. doi: 10.1038/s41433-024-03030-3. Online ahead of print.ABSTRACTHerpes Zoster (HZ) or shingles is the reactivation of the Varicella Zoster Virus (VZV), usually along a single sensory nerve, but can affect both sensory and motor cranial nerves. Major risk factors for HZ include immunosuppressed status and age older than 60 years. In the United States, the lifetime risk of HZ is approximately 30%. Worldwide, the median incidence of HZ is 4-4.5 per 1000 person-years across the Americas, Eurasia, and Australia. HZ ophthalmicus, occurring in 10-20% of patients, is an ophthalmic emergency characterized by...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Brendan Ka-Lok Tao Deep Soor Jonathan A Micieli Source Type: research
Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage
The timing of antiviral therapy for chronic hepatitis B (CHB) patients with normal alanine transaminase (ALT) or aged (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 27, 2024 Category: Gastroenterology Authors: Sufang Wei, Qiuli Xie, Guichan Liao, Hongjie Chen, Meixin Hu, Xiaoli Lin, Hong Li and Jie Peng Tags: Research Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Herpes)
Source: Herpes - March 26, 2024 Category: Infectious Diseases Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 26, 2024 Category: Urology & Nephrology Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Risk of HBV reactivation in HCC patients undergoing combination therapy of PD-1 inhibitors and angiogenesis inhibitors in the antiviral era
CONCLUSION: HBeAg-positive patients receiving combination therapy have a 17-fold higher risk of HBVr than HBeAg-negative patients with PD-1 inhibitors monotherapy.PMID:38530426 | DOI:10.1007/s00432-024-05677-7 (Source: Cell Research)
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Rui Wang Guili Tan Dingjia Lei Yadi Li JiaoJiao Gong Yao Tang Hao Pang Huating Luo Bo Qin Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Herpes)
Source: Herpes - March 26, 2024 Category: Infectious Diseases Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 26, 2024 Category: Urology & Nephrology Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 26, 2024 Category: Urology & Nephrology Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 26, 2024 Category: Urology & Nephrology Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research
