Switching Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide Fumarate (TAF) in Hepatitis B/HIV Co-Infection: A Feasibility Study
Clin Ther. 2023 Dec 23:S0149-2918(23)00465-4. doi: 10.1016/j.clinthera.2023.11.016. Online ahead of print.ABSTRACTPURPOSE: Tenofovir alafenamide (TAF) delivers the active metabolite more efficiently to target cells compared with tenofovir disoproxil fumarate (TDF). Recent studies suggest that TAF is efficacious in treatment naïve individuals who are co-infected with HBV/HIV and may have superior effects on HBV e antigen (HBeAg) seroconversion in this setting. The primary objective of this study was to explore the feasibility of switching from TDF to TAF in HBV/HIV co-infection.METHODS: In this single-arm, multicenter, ope...
Source: Clinical Therapeutics - December 24, 2023 Category: Drugs & Pharmacology Authors: James Lok Maria Fernanda Guerra Veloz Ruth Byrne Ivana Carey Kate Childs Kosh Agarwal Mark Nelson Source Type: research
Switching Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide Fumarate (TAF) in Hepatitis B/HIV Co-Infection: A Feasibility Study
Clin Ther. 2023 Dec 23:S0149-2918(23)00465-4. doi: 10.1016/j.clinthera.2023.11.016. Online ahead of print.ABSTRACTPURPOSE: Tenofovir alafenamide (TAF) delivers the active metabolite more efficiently to target cells compared with tenofovir disoproxil fumarate (TDF). Recent studies suggest that TAF is efficacious in treatment naïve individuals who are co-infected with HBV/HIV and may have superior effects on HBV e antigen (HBeAg) seroconversion in this setting. The primary objective of this study was to explore the feasibility of switching from TDF to TAF in HBV/HIV co-infection.METHODS: In this single-arm, multicenter, ope...
Source: Clinical Therapeutics - December 24, 2023 Category: Drugs & Pharmacology Authors: James Lok Maria Fernanda Guerra Veloz Ruth Byrne Ivana Carey Kate Childs Kosh Agarwal Mark Nelson Source Type: research
Switching Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide Fumarate (TAF) in Hepatitis B/HIV Co-Infection: A Feasibility Study
Clin Ther. 2023 Dec 23:S0149-2918(23)00465-4. doi: 10.1016/j.clinthera.2023.11.016. Online ahead of print.ABSTRACTPURPOSE: Tenofovir alafenamide (TAF) delivers the active metabolite more efficiently to target cells compared with tenofovir disoproxil fumarate (TDF). Recent studies suggest that TAF is efficacious in treatment naïve individuals who are co-infected with HBV/HIV and may have superior effects on HBV e antigen (HBeAg) seroconversion in this setting. The primary objective of this study was to explore the feasibility of switching from TDF to TAF in HBV/HIV co-infection.METHODS: In this single-arm, multicenter, ope...
Source: Clinical Therapeutics - December 24, 2023 Category: Drugs & Pharmacology Authors: James Lok Maria Fernanda Guerra Veloz Ruth Byrne Ivana Carey Kate Childs Kosh Agarwal Mark Nelson Source Type: research
Viruses, Vol. 16, Pages 35: Metabolic Enzymes in Viral Infection and Host Innate Immunity
ghui Feng
Metabolic enzymes are central players for cell metabolism and cell proliferation. These enzymes perform distinct functions in various cellular processes, such as cell metabolism and immune defense. Because viral infections inevitably trigger host immune activation, viruses have evolved diverse strategies to blunt or exploit the host immune response to enable viral replication. Meanwhile, viruses hijack key cellular metabolic enzymes to reprogram metabolism, which generates the necessary biomolecules for viral replication. An emerging theme arising from the metabolic studies of viral infection is that metaboli...
Source: Viruses - December 24, 2023 Category: Virology Authors: Chao Qin Taolin Xie Wayne Wei Yeh Ali Can Savas Pinghui Feng Tags: Review Source Type: research
Orbital apex syndrome in herpes zoster ophthalmicus clinical features, treatment and outcomes: a case series and literature review
We present four patients with HZO OAS, to highlight clinical features and outcomes in order to promote earlier recognition and management of this potentially sight-threatening complication. CT and MRI imaging findings included expansion and enhancement of extraocular muscles and intraconal fat and involvement of the orbital apex and cavernous sinus. All patients received systemic steroid and antiviral therapy, but a standardised dosage and duration of treatment remains to be defined. Final visual acuity and extraocular motility outcomes were variable.PMID:38108804 | DOI:10.1080/01676830.2023.2295473 (Source: Herpes)
Source: Herpes - December 18, 2023 Category: Infectious Diseases Authors: Jessica X L Li Jessica Y Tong Krishna Tumuluri Source Type: research
Orbital apex syndrome in herpes zoster ophthalmicus clinical features, treatment and outcomes: a case series and literature review
We present four patients with HZO OAS, to highlight clinical features and outcomes in order to promote earlier recognition and management of this potentially sight-threatening complication. CT and MRI imaging findings included expansion and enhancement of extraocular muscles and intraconal fat and involvement of the orbital apex and cavernous sinus. All patients received systemic steroid and antiviral therapy, but a standardised dosage and duration of treatment remains to be defined. Final visual acuity and extraocular motility outcomes were variable.PMID:38108804 | DOI:10.1080/01676830.2023.2295473 (Source: Orbit)
Source: Orbit - December 18, 2023 Category: Opthalmology Authors: Jessica X L Li Jessica Y Tong Krishna Tumuluri Source Type: research
Orbital apex syndrome in herpes zoster ophthalmicus clinical features, treatment and outcomes: a case series and literature review
We present four patients with HZO OAS, to highlight clinical features and outcomes in order to promote earlier recognition and management of this potentially sight-threatening complication. CT and MRI imaging findings included expansion and enhancement of extraocular muscles and intraconal fat and involvement of the orbital apex and cavernous sinus. All patients received systemic steroid and antiviral therapy, but a standardised dosage and duration of treatment remains to be defined. Final visual acuity and extraocular motility outcomes were variable.PMID:38108804 | DOI:10.1080/01676830.2023.2295473 (Source: Herpes)
Source: Herpes - December 18, 2023 Category: Infectious Diseases Authors: Jessica X L Li Jessica Y Tong Krishna Tumuluri Source Type: research
Orbital apex syndrome in herpes zoster ophthalmicus clinical features, treatment and outcomes: a case series and literature review
We present four patients with HZO OAS, to highlight clinical features and outcomes in order to promote earlier recognition and management of this potentially sight-threatening complication. CT and MRI imaging findings included expansion and enhancement of extraocular muscles and intraconal fat and involvement of the orbital apex and cavernous sinus. All patients received systemic steroid and antiviral therapy, but a standardised dosage and duration of treatment remains to be defined. Final visual acuity and extraocular motility outcomes were variable.PMID:38108804 | DOI:10.1080/01676830.2023.2295473 (Source: Orbit)
Source: Orbit - December 18, 2023 Category: Opthalmology Authors: Jessica X L Li Jessica Y Tong Krishna Tumuluri Source Type: research
Viruses, Vol. 15, Pages 2451: Metformin and Hepatocellular Carcinoma Risk Reduction in Diabetic Patients with Chronic Hepatitis C: Fact or Fiction?
Conclusion: according to the current evidence, the use of MET should be encouraged in diabetic patients with CHC in order to reduce the risk of HCC; however, a well-designed randomized controlled trial is needed to establish the generalizability of the beneficial effects of MET in this particular subset of patients. (Source: Viruses)
Source: Viruses - December 17, 2023 Category: Virology Authors: Marco Sacco Davide Giuseppe Ribaldone Giorgio Maria Saracco Tags: Review Source Type: research
High-throughput virtual screening to identify potential small molecule inhibitors of the Z α domain of the adenosine deaminases acting on RNA 1(ADAR1)
This study provides a new perspective for the search of ADAR1 inhibitors, and further studies on the anti-ADAR11 activity of these compounds have broad prospects.PMID:38103658 | DOI:10.1016/j.ejps.2023.106672 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Xiaoshan Hong Zhifu Wei Lulu He Qiaowen Bu Guosong Wu Guanqiao Chen Wanshan He Qiuhua Deng Shiqi Huang Yongmei Huang Cai Yu Xiping Luo Yu Lin Source Type: research
High-throughput virtual screening to identify potential small molecule inhibitors of the Z α domain of the adenosine deaminases acting on RNA 1(ADAR1)
This study provides a new perspective for the search of ADAR1 inhibitors, and further studies on the anti-ADAR11 activity of these compounds have broad prospects.PMID:38103658 | DOI:10.1016/j.ejps.2023.106672 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 16, 2023 Category: Drugs & Pharmacology Authors: Xiaoshan Hong Zhifu Wei Lulu He Qiaowen Bu Guosong Wu Guanqiao Chen Wanshan He Qiuhua Deng Shiqi Huang Yongmei Huang Cai Yu Xiping Luo Yu Lin Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Herpes)
Source: Herpes - December 15, 2023 Category: Infectious Diseases Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
Impact of antiviral therapy on short- and long-term outcomes of patients with chronic obstructive pulmonary disease after influenza infection
CONCLUSIONS: Antiviral treatment in patients with COPD and influenza is associated with significantly lower HRU and costs in the postinfection month and for an entire year following infection compared with untreated patients.PMID:38098649 | PMC:PMC10719080 | DOI:10.1111/irv.13231 (Source: Respiratory Care)
Source: Respiratory Care - December 15, 2023 Category: Respiratory Medicine Authors: Christopher Wallick Tu My To Stephan Korom Henry Masters Ning Wu Dalia Moawad Nicola A Hanania Source Type: research
Multidermatomal herpes zoster triggered by psychological stress in an immunocompetent young adult: a rare case report and clinical insights
CONCLUSION: This case underscores the rare occurrence of multidermatomal HZ in an immunocompetent young adult triggered by psychological stress. The atypical presentation and potential role of stress in viral reactivation emphasize the complex interaction between the nervous and immune systems. Integrated clinical management, stress reduction strategies, and antiviral therapy were effective in resolving the condition. Further research is warranted to elucidate the mechanisms underlying stress-induced viral reactivation and its clinical implications.PMID:38098591 | PMC:PMC10718367 | DOI:10.1097/MS9.0000000000001409 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Tek N Yogi Amrit Bhusal Suman Subedi Shailendra Katwal Kshitiz Acharya Source Type: research
