A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients
CONCLUSIONS: Among 31 episodes of HSV treated with foscarnet, only half resolved with treatment, and adverse events were common.PMID:38444818 | PMC:PMC10914364 | DOI:10.1093/ofid/ofae046 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Sarah P Hammond Manickam Rangaraju Melanie Sumner Burkhard Timmler Pranatharthi Chandrasekar Robin K Avery Source Type: research
Sofosbuvir (+) daclatasvir (+) ribavirin in Egyptian patients with hepatitis C virus: Therapeutic outcomes and the prognostic role of natural killer cells
CONCLUSION: NK cell activation following SOF (+) DCV (+) RBV therapy and polarization to cytotoxicity occurred early in HCV antiviral therapy and was elevated in the respondents. Our data illustrated that establishing an inhibitory cytotoxic NK profile is related to therapeutic outcomes.PMID:38447269 | DOI:10.1016/j.retram.2024.103443 (Source: Cell Research)
Source: Cell Research - March 6, 2024 Category: Cytology Authors: Ahmed B Zaid Shimaa K Almady Samah M Awad Mona G Elabd Sara A Saied AbdulRahman A Saied Alshimaa M Elmalawany Source Type: research
A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients
CONCLUSIONS: Among 31 episodes of HSV treated with foscarnet, only half resolved with treatment, and adverse events were common.PMID:38444818 | PMC:PMC10914364 | DOI:10.1093/ofid/ofae046 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Sarah P Hammond Manickam Rangaraju Melanie Sumner Burkhard Timmler Pranatharthi Chandrasekar Robin K Avery Source Type: research
Chronic Hepatitis B in Women of Childbearing Age and Pregnant Women in China: A Cross-Sectional Study
Am J Trop Med Hyg. 2024 Mar 5:tpmd230217. doi: 10.4269/ajtmh.23-0217. Online ahead of print.ABSTRACTPregnant women and women of childbearing age were enrolled in our study and their knowledge about the Hepatitis B virus (HBV) and chronic hepatitis B (CHB) was evaluated. A questionnaire was distributed to every woman in the cross-sectional study. The questionnaire was answered by all participants before they received health education and advice about HBV and CHB from the doctors visited. Data collected from all answers were analyzed using the χ2 test and logistic regression models. A total of 206 pregnant women and women o...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Liyang Zhou Xitao Liu Xueting Ou Qiongyu Sheng Bing Situ Fang He Xingfei Pan Source Type: research
Chronic Hepatitis B in Women of Childbearing Age and Pregnant Women in China: A Cross-Sectional Study
Am J Trop Med Hyg. 2024 Mar 5:tpmd230217. doi: 10.4269/ajtmh.23-0217. Online ahead of print.ABSTRACTPregnant women and women of childbearing age were enrolled in our study and their knowledge about the Hepatitis B virus (HBV) and chronic hepatitis B (CHB) was evaluated. A questionnaire was distributed to every woman in the cross-sectional study. The questionnaire was answered by all participants before they received health education and advice about HBV and CHB from the doctors visited. Data collected from all answers were analyzed using the χ2 test and logistic regression models. A total of 206 pregnant women and women o...
Source: Am J Trop Med Hyg - March 5, 2024 Category: Infectious Diseases Authors: Liyang Zhou Xitao Liu Xueting Ou Qiongyu Sheng Bing Situ Fang He Xingfei Pan Source Type: research
Enhancing Efficacy and Quality of Life in Patients with Herpes Zoster Infection in Hairy Cell Leukemia
In this study, we present the case of a 71-year-old female patient with a previous diagnosis of variant HCL who experienced a severe herpes zoster infection leading to an extensive skin eruption. The patient's initial diagnosis of HCL occurred 7 years ago, and she underwent treatment with cladribine, interferon, COP (cyclophosphamide, vincristine, and prednisone), benztropine tablets + clarithromycin dispersible, and ibrutinib. Immune disorders resulting from repeated prior chemotherapy and targeted therapy may potentially precipitate herpes zoster infection. Despite an initial two-week period of unresponsiveness to antivi...
Source: Herpes - March 5, 2024 Category: Infectious Diseases Authors: Xiaowei Feng Yuchen Tao Qi Hu Yuanxia Liu Jizhang Bao Wenwen Jiang Source Type: research
Chronic Hepatitis B in Women of Childbearing Age and Pregnant Women in China: A Cross-Sectional Study
Am J Trop Med Hyg. 2024 Mar 5:tpmd230217. doi: 10.4269/ajtmh.23-0217. Online ahead of print.ABSTRACTPregnant women and women of childbearing age were enrolled in our study and their knowledge about the Hepatitis B virus (HBV) and chronic hepatitis B (CHB) was evaluated. A questionnaire was distributed to every woman in the cross-sectional study. The questionnaire was answered by all participants before they received health education and advice about HBV and CHB from the doctors visited. Data collected from all answers were analyzed using the χ2 test and logistic regression models. A total of 206 pregnant women and women o...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Liyang Zhou Xitao Liu Xueting Ou Qiongyu Sheng Bing Situ Fang He Xingfei Pan Source Type: research
Chronic Hepatitis B in Women of Childbearing Age and Pregnant Women in China: A Cross-Sectional Study
Am J Trop Med Hyg. 2024 Mar 5:tpmd230217. doi: 10.4269/ajtmh.23-0217. Online ahead of print.ABSTRACTPregnant women and women of childbearing age were enrolled in our study and their knowledge about the Hepatitis B virus (HBV) and chronic hepatitis B (CHB) was evaluated. A questionnaire was distributed to every woman in the cross-sectional study. The questionnaire was answered by all participants before they received health education and advice about HBV and CHB from the doctors visited. Data collected from all answers were analyzed using the χ2 test and logistic regression models. A total of 206 pregnant women and women o...
Source: Am J Trop Med Hyg - March 5, 2024 Category: Infectious Diseases Authors: Liyang Zhou Xitao Liu Xueting Ou Qiongyu Sheng Bing Situ Fang He Xingfei Pan Source Type: research
Chronic Hepatitis B in Women of Childbearing Age and Pregnant Women in China: A Cross-Sectional Study
Am J Trop Med Hyg. 2024 Mar 5:tpmd230217. doi: 10.4269/ajtmh.23-0217. Online ahead of print.ABSTRACTPregnant women and women of childbearing age were enrolled in our study and their knowledge about the Hepatitis B virus (HBV) and chronic hepatitis B (CHB) was evaluated. A questionnaire was distributed to every woman in the cross-sectional study. The questionnaire was answered by all participants before they received health education and advice about HBV and CHB from the doctors visited. Data collected from all answers were analyzed using the χ2 test and logistic regression models. A total of 206 pregnant women and women o...
Source: The American Journal of Tropical Medicine and Hygiene - March 5, 2024 Category: Tropical Medicine Authors: Liyang Zhou Xitao Liu Xueting Ou Qiongyu Sheng Bing Situ Fang He Xingfei Pan Source Type: research
Point-of-care ultrasound to inform antiviral treatment initiation in chronic hepatitis B virus infection in low-resource settings – the PUSH protocol
ConclusionUltrasound can facilitate same-day initiation of antiviral therapy for chronic HBV monoinfection in a resource-limited setting and a streamlined protocol-driven liver ultrasound can be feasibly used by front line clinicians managing HBV. (Source: Critical Ultrasound Journal)
Source: Critical Ultrasound Journal - March 4, 2024 Category: Radiology Source Type: research
Longer-term Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Trial
Clinical question: What is the longer-term (180-day) mortality effect of common therapies on critically ill patients with COVID-19?
Background: Most randomized clinical trials for patients with COVID-19 focus on short-term outcomes such as 28-day mortality or organ failure. Trials evaluating longer-term outcomes of therapeutic interventions are needed.
Study design: Randomized adaptive-platform trial
Setting: International multicenter trial (197 sites in 14 countries)
Synopsis: 4,869 critically ill patients were enrolled from March 2020 through June 2021. Patients were randomized to one of six treatment arms (immune modula...
Source: The Hospitalist - March 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: COVID-19 In the Literature Source Type: research
Tenofovir versus entecavir on recurrence and mortality of hepatitis B virus-related hepatocellular carcinoma after curative therapy
CONCLUSIONS: TDF therapy is associated with a reduced risk of HCC-related outcomes among patients with HBV-related HCC after curative intent treatment compared with ETV usage.PMID:38423922 | DOI:10.1016/j.jfma.2024.02.011 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 29, 2024 Category: General Medicine Authors: Kai-Chun Chang Tung-Hung Su Sih-Han Liao Tai-Chung Tseng Shang-Chin Huang Shih-Jer Hsu Chun-Ming Hong Chen-Hua Liu Hung-Chih Yang Chun-Jen Liu Jia-Horng Kao Source Type: research
Tenofovir versus entecavir on recurrence and mortality of hepatitis B virus-related hepatocellular carcinoma after curative therapy
CONCLUSIONS: TDF therapy is associated with a reduced risk of HCC-related outcomes among patients with HBV-related HCC after curative intent treatment compared with ETV usage.PMID:38423922 | DOI:10.1016/j.jfma.2024.02.011 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 29, 2024 Category: General Medicine Authors: Kai-Chun Chang Tung-Hung Su Sih-Han Liao Tai-Chung Tseng Shang-Chin Huang Shih-Jer Hsu Chun-Ming Hong Chen-Hua Liu Hung-Chih Yang Chun-Jen Liu Jia-Horng Kao Source Type: research
Use of Remdesivir in children with COVID-19: report of an Italian multicenter study
ConclusionOur experience indicates that RDV against SARS-CoV-2 is safe and well-tolerated in pediatric populations at high risk of developing severe COVID-19. Our data suggest that delaying RDV therapy after diagnosis of pneumonia may be associated with a longer duration of antiviral therapy, especially in patients with comorbidities. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 27, 2024 Category: Pediatrics Source Type: research
When to Stop Antiviral Therapy in HBeAg-Negative Patients with Chronic Hepatitis B?
AbstractPurpose of ReviewThe strategy of finite nucleos(t)ide analogue (Nuc) therapy in HBeAg-negative patients has been increasingly accepted globally, and when to stop therapy has become an important issue. This review aimed to address this issue.Recent FindingsThe incidence of off-therapy relapse is lower with lower end-of-therapy (EOT) HBsAg level. Pretherapy HBV DNA < 20,000 IU/mL, on-treatment HBV DNA undetectable by week 12, treatment duration > 3 years, on-treatment HBsAg decline > 1 log10 IU/mL, and EOT HBsAg < 100 IU/mL are also factors for increasing off-therapy HBsAg loss. O...
Source: Current Hepatitis Reports - February 23, 2024 Category: Infectious Diseases Source Type: research
