Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS ‐COV‐2 targeting main protease and papain‐like protease
AbstractThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be over, but its variants continue to emerge, and patients with mild symptoms having long COVID is still under investigation. SARS-CoV-2 infection leading to elevated cytokine levels and suppressed immune responses set off cytokine storm, fatal systemic inflammation, tissue damage, and multi-organ failure. Thus, drug molecules targeting the SARS-CoV-2 virus-specific proteins or capable of suppressing the host inflammatory responses to viral infection would provide an effective antiviral thera...
Source: IUBMB Life - December 8, 2023 Category: Research Authors: Shweta Choudhary,
Sanketkumar Nehul,
Ankur Singh,
Prasan Kumar Panda,
Pravindra Kumar,
Gaurav Kumar Sharma,
Shailly Tomar Tags: SPECIAL ISSUE Source Type: research
Congenital herpes simplex with ophthalmic and multisystem features: a case report
CONCLUSIONS: In the management of neonatal HSV, early diagnosis is essential for the timely initiation of antiviral therapy. Our report highlights that ocular assessment can be crucial in the correct diagnostic investigation of this condition.PMID:38044450 | DOI:10.1186/s12887-023-04423-1 (Source: Herpes)
Source: Herpes - December 3, 2023 Category: Infectious Diseases Authors: Samuel Montenegro Pereira Rian Vilar Lima Maria Carolina Rocha Muniz Marcus Breno Farias Ara újo Luiz de Moraes Ferreira J únior Juliana Tiburtino de Queiroz Sales Martins Cl áudia Faustino Coelho Luz David Ant ônio Camelo Cid Daniel da Rocha Lucena Source Type: research
The effect of switch therapy to tenofovir versus entecavir maintenance on recurrence of hepatocellular carcinoma after surgery (SWITE): study protocol for a randomized controlled trial
Antiviral therapy has been reported to be associated with lower recurrence rate of hepatocellular carcinoma (HCC) for patients with hepatitis B virus (HBV) infection. While entecavir (ETV) and tenofovir disopr... (Source: Trials)
Source: Trials - December 2, 2023 Category: General Medicine Authors: Wei Peng, Mengshi Yi, Xin Qi, Weili Qi, Chuan Li and Tianfu Wen Tags: Methodology Source Type: research
Skeletal muscle mass is significantly increased after direct-acting antiviral therapy in patients with chronic hepatitis C
Rationale: In chronic hepatitis C (CHC), the mechanisms behind sarcopenia have not been completely clarified. Thus, we investigated skeletal muscle mass and liver function before and after sustained virological response (SVR) to DAA therapy patients with CHC. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: M.P.P. Coelho, T.P. de Vries, A.M. Pires, É.R. de Alvarenga, R.D. Cambraia, J.M.T. Bezerra, E.A. Colosimo, G.A. Rocha, L.D. Silva, Nutriclim - Grupo Interdisciplinar e Interprofissional em Nutrição Clínica e Metabolismo Source Type: research
CO121 Prevalence of Musculoskeletal and Renal Outcomes in Patients With Chronic Hepatitis B Undergoing Antiviral Treatments in a Real-World Setting
This study aimed to examine the prevalence of musculoskeletal and renal outcomes in patients receiving ENT, TDF, and TAF. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: H. Lee, B.K. Kim, A. Kim Source Type: research
Pseudotumoral herpes genitalis in a woman living with HIV: Diagnosis and treatment challenges
We present a case of woman living with HIV with pseudotumoral vulvar herpes refractory to oral acyclovir, successfully treated with systemic foscarnet and topical imiquimod.PMID:38031871 | DOI:10.1177/09564624231218759 (Source: Herpes)
Source: Herpes - November 30, 2023 Category: Infectious Diseases Authors: Mar ía V Tomaino Macarena Sanchez Costantini Carmen T Alfaro Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Pseudotumoral herpes genitalis in a woman living with HIV: Diagnosis and treatment challenges
We present a case of woman living with HIV with pseudotumoral vulvar herpes refractory to oral acyclovir, successfully treated with systemic foscarnet and topical imiquimod.PMID:38031871 | DOI:10.1177/09564624231218759 (Source: Herpes)
Source: Herpes - November 30, 2023 Category: Infectious Diseases Authors: Mar ía V Tomaino Macarena Sanchez Costantini Carmen T Alfaro Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research
