Long-term incidence, risk factors and complications for venous thromboembolism in patients with systemic lupus erythematosus
CONCLUSIONS: VTE affected 12.8% of patients with SLE at six times the VTE rate in controls with aPL as the strongest, but not the only risk factor in SLE. The risk of PH was increased in both groups following PE, but VTE did not associate with an increased risk of arterial events.PMID:38655753 | DOI:10.1177/09612033241247359 (Source: Lupus)
Source: Lupus - April 24, 2024 Category: Rheumatology Authors: Johannes Cornelis Nossent Helen Isobel Keen David Brian Preen Charles Anoukpar Inderjeeth Source Type: research
Eculizumab administration for myasthenia gravis also stabilizes thrombogenicity of catastrophic antiphospholipid syndrome
ConclusionsEculizumab can be effective for controlling multiple complement-mediated pathophysiology. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 23, 2024 Category: Neurology Authors: Sunao Takahashi,
Nobuo Sanjo,
Ryuji Koike,
Takanori Yokota Tags: CASE REPORT Source Type: research
Antiphospholipid Patients Admitted in the Intensive Care Unit: What Must The Rheumatologist Know?
AbstractPurpose of the reviewAntiphospholipid syndrome (APS) is a rare systemic autoimmune disorder that can escalate into a 'thrombotic storm' called the catastrophic antiphospholipid syndrome (CAPS), frequently requiring ICU admission for multiple organ failure. This review aims to offer insight and recent evidence on critically-ill APS patients.Recent findingsThe CAPS classification criteria define this condition as the involvement of at least three organs/systems/tissues within less than a week, caused by small vessel thrombosis, in patients with elevated antiphospholipid antibodies levels. These criteria do not encomp...
Source: Current Rheumatology Reports - April 23, 2024 Category: Rheumatology Source Type: research
T cell involvement in antiphospholipid syndrome
Clin Immunol. 2024 Apr 17:110218. doi: 10.1016/j.clim.2024.110218. Online ahead of print.ABSTRACTAntiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis, and obstetric complications in the presence of antiphospholipid antibodies (aPL), including lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies, manifesting as single, or often as recurrent events, and rarely as a catastrophic condition. Most studies of APS pathogenesis to date have focused on the prothrombotic role of aPL, while innate immune components such as monocyte, complement and neut...
Source: Clinical Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Maria G Tektonidou Nikolaos I Vlachogiannis Petros P Sfikakis Source Type: research
Waldmann's disease: Primary intestinal lymphangiectasia diagnosed by 99mTc ‐labeled albumin macroaggregate scintigraphy—A case report in an adult patient
Key Clinical MessageRare yet significant, this case sheds light on the uncommon presentation of Waldmann's disease in adults, showcasing the diagnostic challenges it poses. A multidisciplinary approach, integrating clinical, endoscopic, histological, and radiological evaluations, is crucial for accurate diagnosis and management. Further research is needed to deepen our understanding of this complex disorder.AbstractWaldmann's disease, or primary intestinal lymphangiectasia, is a rare disorder characterized by protein-losing enteropathy due to dilation and leakage of intestinal lymphatic vessels. Although typically diagnose...
Source: Clinical Case Reports - April 17, 2024 Category: General Medicine Authors: Alex Jos é Castellón Méndez,
Allan Bodán Campbell,
Victor Rosales Obregón,
Mohammed Zahran Tags: CASE REPORT Source Type: research
Testing for the lupus anticoagulant: the good, the bad, and the ugly
Res Pract Thromb Haemost. 2024 Mar 18;8(3):102385. doi: 10.1016/j.rpth.2024.102385. eCollection 2024 Mar.ABSTRACTLupus anticoagulant (LA) represents 1 of the laboratory criteria for classification of patients as having definite antiphospholipid syndrome (APS). The other 2 laboratory criteria are anticardiolipin antibodies and anti-beta2-glycoprotein I antibodies. At least 1 of these antiphospholipid antibody (aPL) tests need to be positive, with evidence of persistence, together with evidence of at least 1 clinical criterion for APS, before a patient can be classified as having definite APS. LA and other aPL assays are als...
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Emmanuel J Favaloro Leonardo Pasalic Rita Selby Source Type: research
Testing for the lupus anticoagulant: the good, the bad, and the ugly
Res Pract Thromb Haemost. 2024 Mar 18;8(3):102385. doi: 10.1016/j.rpth.2024.102385. eCollection 2024 Mar.ABSTRACTLupus anticoagulant (LA) represents 1 of the laboratory criteria for classification of patients as having definite antiphospholipid syndrome (APS). The other 2 laboratory criteria are anticardiolipin antibodies and anti-beta2-glycoprotein I antibodies. At least 1 of these antiphospholipid antibody (aPL) tests need to be positive, with evidence of persistence, together with evidence of at least 1 clinical criterion for APS, before a patient can be classified as having definite APS. LA and other aPL assays are als...
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Emmanuel J Favaloro Leonardo Pasalic Rita Selby Source Type: research
Predictors of damage accrual and its impact on health-related quality of life of thrombotic antiphospholipid syndrome: Independent validation of the damage index for antiphospholipid syndrome (DIAPS)
CONCLUSION: This external validation of DIAPS reinforces the ability of the score to correlate with HR-QoL while also highlighting risk factors for HR-QoL impairment other than damage accrual.PMID:38616341 | DOI:10.1177/09612033241246360 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Pedro Gaspar Ana Sofia M Fernandes Ana Mafalda Abrantes In ês Parreira In ês Silva Ryan C Silva Mariana B Nobre Joana R Martins Catarina Mota Source Type: research
Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
Conclusion
This study provided a comprehensive decidual cell landscape and identified aberrant decidual microenvironment in OAPS, providing some potential therapeutic targets for this disease. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Lu, C., Gao, R., Qing, P., Zeng, X., Liao, X., Cheng, M., Qin, L., Liu, Y. Tags: ARD, Autoimmunity Source Type: research
Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
DISCUSSION: Rheumatological screening led to suspicion of a possible or probable autoimmune psychotic syndrome in 4%. ANAs were associated with MRI pathologies. Therefore, rheumatological processes may contribute to the development of psychotic syndromes in rare cases.PMID:38599500 | DOI:10.1016/j.bbi.2024.04.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Dominique Endres Katharina von Zedtwitz Kathrin Nickel Kimon Runge Alexander Maier Katharina Domschke Ulrich Salzer Harald Pr üss Nils Venhoff Ludger Tebartz van Elst Source Type: research
Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
DISCUSSION: Rheumatological screening led to suspicion of a possible or probable autoimmune psychotic syndrome in 4%. ANAs were associated with MRI pathologies. Therefore, rheumatological processes may contribute to the development of psychotic syndromes in rare cases.PMID:38599500 | DOI:10.1016/j.bbi.2024.04.001 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 10, 2024 Category: Neurology Authors: Dominique Endres Katharina von Zedtwitz Kathrin Nickel Kimon Runge Alexander Maier Katharina Domschke Ulrich Salzer Harald Pr üss Nils Venhoff Ludger Tebartz van Elst Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Primary antiphospholipid syndrome in a male presents with acute digital ischemia: Dramatic response to glucocorticoid
We present a rare case of primary antiphospholipid syndrome in a 38-year-old male who presented with painful digital ischemia. Early initiation of anticoagulation and addition of glucocorticoid led to a significant improvement in the patient. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 9, 2024 Category: General Medicine Authors: Tanvir Ahammed,
Mohammad Rasel,
Sourav Saha,
Ashif Istiak,
Sabreena Chowdhury Tags: CASE REPORT Source Type: research
Noncriteria antiphospholipid antibodies in antiphospholipid syndrome
Int J Lab Hematol. 2024 Apr 7. doi: 10.1111/ijlh.14268. Online ahead of print.ABSTRACTAntiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombotic manifestations and/or obstetric complications in patients with persistently positive antiphospholipid antibodies (aPL). aPL are a heterogeneous group of autoantibodies, but only lupus anticoagulant, anticardiolipin (aCL), and antibeta2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are included as laboratory classification criteria. Seronegative APS patients are usually defined as patients with the clinical symptoms of APS but who test negative for aPL. T...
Source: International Journal of Laboratory Hematology - April 7, 2024 Category: Hematology Authors: Katrien M J Devreese Source Type: research
