T cell involvement in antiphospholipid syndrome

Clin Immunol. 2024 Apr 17:110218. doi: 10.1016/j.clim.2024.110218. Online ahead of print.ABSTRACTAntiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis, and obstetric complications in the presence of antiphospholipid antibodies (aPL), including lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies, manifesting as single, or often as recurrent events, and rarely as a catastrophic condition. Most studies of APS pathogenesis to date have focused on the prothrombotic role of aPL, while innate immune components such as monocyte, complement and neutrophil activation have been recently recognized as part of the thrombo-inflammatory cascade in APS. While the presence of autoreactive T cells against β2-glycoprotein I has been long known, limited data are available on their role in APS. In this review, we summarize current knowledge on the involvement of T cells in APS pathophysiology, alterations of T cell subsets in peripheral blood, and clinical associations. We also highlight potential therapeutic opportunities by targeting T helper-B cell interactions in these patients.PMID:38640985 | DOI:10.1016/j.clim.2024.110218
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research