Insight into antiphospholipid syndrome: the role and clinical utility of neutrophils extracellular traps formation
Antiphospholipid syndrome (APLS) is a systemic immune dysregulation distinguished by repetitive complications and pregnancy loss in the absence of definite etiology. Most research focuses on the laboratory det... (Source: Thrombosis Journal)
Source: Thrombosis Journal - March 28, 2024 Category: Hematology Authors: Shams ElDoha Galal ElDin Zaiema, Menna Allah Zakaria Mohammad Ali Abou Elwafa, Shaymaa Gamal Arafa Hassan, Radwa Hassan Abou El Fotoh El Adwey, Raghda Mohammed Mostafa Ghorab and Raghda El Sayed Abdel Monem Galal Tags: Research Source Type: research
Challenging in leprosy relapse with antiphospholipid syndrome diagnosis: A case report
This report emphasizes the importance of considering a broad differential diagnosis, including the potential for infectious disease relapse, in the presence of antiphospholipid antibodies. It illustrates the necessity of an interdisciplinary treatment approach in complex clinical scenarios. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 27, 2024 Category: General Medicine Authors: Sousan Kolahi,
Leyla Ghadakchi,
Amirreza Jabbaripour  Sarmadian,
Hamideh Azimi,
Mehdi Jafarpour,
Amirreza Khalaji Tags: CASE REPORT Source Type: research
Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Recurrent venous thrombosis - an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B
S Afr Med J. 2023 Dec 31;114(1):17-21. doi: 10.7196/SAMJ.2024.v114i1.1477.ABSTRACTA 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her rec...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: N Letete D Vaz P H Malishi J J Pogieter P Rheeder Source Type: research
