A young woman with acute coronary syndrome and antiphospholipid syndrome. Is it the antiphospholipid syndrome or COVID-19 vaccination or classical risk as the risk factor? a case report
ConclusionsYoung women are not completely immune to ACS as evident in this case of ACS in a young woman with classical risk factors (dyslipidemia and family history of cardiovascular disease) and APS. Further studies are required to fill the knowledge gap on whether COVID-19 vaccination had any contribution to the ACS in the young woman. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 19, 2024 Category: General Medicine Source Type: research
The effects of hydroxychloroquine and its promising use in refractory obstetric antiphospholipid syndrome
AbstractHydroxychloroquine (HCQ) is obtained by hydroxylation of chloroquine (CQ) and the first indication was malaria. Nowadays, HCQ is commonly used in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) with favorable results. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity and persistent positivity of antiphospholipid antibodies. Around 20 –30% of pregnant women with APS develop adverse pregnancy outcomes despite conventional treatment with aspirin and heparin, called refractory obstetric APS. Interestingly, HCQ has shown positive effects on...
Source: Rheumatology International - January 18, 2024 Category: Rheumatology Source Type: research
Spontaneous coronary artery dissection in a young patient with antiphospholipid syndrome
A 28-year-old man diagnosed with triple positive antiphospholipid syndrome (APS) and undergoing warfarin experienced three separate admissions to the cardiac ward within a one-month period due to escalating ch... (Source: Thrombosis Journal)
Source: Thrombosis Journal - January 17, 2024 Category: Hematology Authors: Ai Phi Thuy Ho, Eirik Tj ønnfjord, Oliver Meyerdierks and Ellen Elisabeth Brodin Tags: Case Report Source Type: research
Calprotectin impairs platelet survival in patients with primary antiphospholipid syndrome
ConclusionsThese data suggest that calprotectin has the potential to be a functional biomarker and a new therapeutic target for APS thrombocytopenia. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 16, 2024 Category: Rheumatology Authors: Claire K. Hoy,
Somanathapura K. NaveenKumar,
Sherwin A. Navaz,
Kavya Sugur,
Srilakshmi Yalavarthi,
Cyrus Sarosh,
Tristin Smith,
Katarina Kmetova,
Emily Chong,
Noah F. Peters,
Christine E. Rysenga,
Gary L. Norman,
Gabriel Figueroa ‐Parra,
Da Tags: Brief Report Source Type: research
Risk Factors for Antiphospholipid Antibodies and Antiphospholipid Syndrome
Semin Thromb Hemost DOI: 10.1055/s-0043-1776910Persistence of serum antiphospholipid antibodies (aPL) is associated with a high thrombotic risk, both arterial and venous, and with pregnancy complications. Due to the potential morbidity and mortality associated with the presence of aPL, identifying and recognizing risk factors for the development of aPL and thrombosis in aPL carriers may help to prevent and reduce the burden of disease. Multiple elements are involved in the pathomechanism of aPL development and aPL-related thrombosis such as genetics, malignancy, and infections. This review will address the role of both wel...
Source: Seminars in Thrombosis and Hemostasis - January 16, 2024 Category: Hematology Authors: Aguirre del-Pino, Rodrigo Monahan, Rory C. Huizinga, Tom W.J. Eikenboom, Jeroen Steup-Beekman, Gerda M. Tags: Review Article Source Type: research
Response to “Correspondence/Comments on ACR/EULAR Antiphospholipid Syndrome Classification Criteria” by Alijotas‐Reig et al.
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 12, 2024 Category: Rheumatology Authors: Medha Barbhaiya,
Stephane Zuily,
Alison Hendry,
Florian Manneville,
Francis Guillemin,
Karen Costenbader,
Doruk Erkan Tags: Reply Source Type: research
Correspondence/comments on acr/eular antiphospholipid syndrome classification criteria
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 11, 2024 Category: Rheumatology Authors: J Jaume Alijotas ‐Reig,
Joana Marques‐Soares,
Cristina Belizna,
Enrique Esteve‐Valverde,
Sebastin Udry,
Raquel Ferrer‐Oliveras,
Arsenne Mekinian,
Luis Saez‐Comet,
Sara de Carolis,
Ariella Hoxha,
Eleftheria Lefkou,
Elisa Llurba,
Patri Tags: Letters Source Type: research
Thrombocytopenia and disease outcomes in a cohort of patients with systemic lupus erythematosus. A post hoc analysis of the COMOSLE ‐EGYPT study
ConclusionThrombocytopenia was associated with more organ damage and higher mortality in SLE patients with or without APL antibodies. SLE patients with thrombocytopenia have a 3.4 times higher risk of mortality than patients without thrombocytopenia. Apart from thrombocytopenia, the male gender was also found to be an independent risk factor for mortality. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - January 11, 2024 Category: Rheumatology Authors: Sally Samy Mohamed,
Sherif Mohamed Gamal,
Abir Mokbel,
Alkhateeb Kadery Alkamary,
Ibrahem Siam,
Ahmed Soliman,
Fatema Talaat Elgengehy Tags: ORIGINAL ARTICLE Source Type: research
Antiphospholipid syndrome: are old school VKAs still the best choice?
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - January 11, 2024 Category: Emergency Medicine Source Type: research
Antiphospholipid syndrome in rural, remote, and First Nations peoples in the Top End of the Northern Territory, Australia
CONCLUSION: There is a high prevalence of APS in First Nations patients living in very remote Australia admitted for tertiary care in the tropical north of the Northern Territory, Australia. The rate of CAPS in First Nations patients was high, and CAPS was associated with significantly shorter survival. Larger prospective studies are required to inform improved models of care for First Nations and remote Australians living with APS.PMID:38193060 | PMC:PMC10772872 | DOI:10.1016/j.rpth.2023.102227 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - January 9, 2024 Category: Hematology Authors: Evangeline Agbayani Chris Doig Tina Noutsos Source Type: research
Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single Center Study
CONCLUSION: Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses.PMID:38195020 | DOI:10.1016/j.cca.2024.117761 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 9, 2024 Category: Chemistry Authors: Abdulrahman Saadalla Vijayalakshmi Nandakumar Source Type: research
Antiphospholipid syndrome in rural, remote, and First Nations peoples in the Top End of the Northern Territory, Australia
CONCLUSION: There is a high prevalence of APS in First Nations patients living in very remote Australia admitted for tertiary care in the tropical north of the Northern Territory, Australia. The rate of CAPS in First Nations patients was high, and CAPS was associated with significantly shorter survival. Larger prospective studies are required to inform improved models of care for First Nations and remote Australians living with APS.PMID:38193060 | PMC:PMC10772872 | DOI:10.1016/j.rpth.2023.102227 (Source: Rural Remote Health)
Source: Rural Remote Health - January 9, 2024 Category: Rural Health Authors: Evangeline Agbayani Chris Doig Tina Noutsos Source Type: research
