Evaluation of Recurrent Pregnancy Loss
Obstet Gynecol. 2024 Jan 4. doi: 10.1097/AOG.0000000000005498. Online ahead of print.ABSTRACTRecurrent pregnancy loss (RPL) affects approximately 5% of couples. Although RPL definitions vary across professional societies, an evaluation after a second clinically recognized first-trimester pregnancy loss is recommended. Good quality evidence links parental chromosomal rearrangements, uterine anomalies, and antiphospholipid syndrome (APS) to RPL. In contrast, the relationship between RPL and other endocrine, hematologic, and immunologic disorders or environmental exposures is less clear. Anticoagulant therapy and low-dose asp...
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Viviana de Assis Claudio Schenone Giugni Stephanie T Ros Source Type: research

Chronic abdominal aortic occlusive disease related to antiphospholipid syndrome: a rare presentation
CONCLUSION: The study shed light on the rare occurrence of CAAOD in APS, highlighting the roles of smoking and hyperhomocysteinaemia as notable risk factors. These findings emphasised the significance of early diagnosis and management of CAAOD.PMID:38176738 | DOI:10.1136/rmdopen-2023-003664 (Source: Atherosclerosis)
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Hui Jiang Yu Shi Wei Liu Bao Liu Yue-Xin Chen Yangzhong Zhou Can Huang Qian Wang Xinping Tian Yan Zhao Mengtao Li Xiaofeng Zeng Jiuliang Zhao Source Type: research

Evaluation of Recurrent Pregnancy Loss
Obstet Gynecol. 2024 Jan 4. doi: 10.1097/AOG.0000000000005498. Online ahead of print.ABSTRACTRecurrent pregnancy loss (RPL) affects approximately 5% of couples. Although RPL definitions vary across professional societies, an evaluation after a second clinically recognized first-trimester pregnancy loss is recommended. Good quality evidence links parental chromosomal rearrangements, uterine anomalies, and antiphospholipid syndrome (APS) to RPL. In contrast, the relationship between RPL and other endocrine, hematologic, and immunologic disorders or environmental exposures is less clear. Anticoagulant therapy and low-dose asp...
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Viviana de Assis Claudio Schenone Giugni Stephanie T Ros Source Type: research

Evaluation of Recurrent Pregnancy Loss
Obstet Gynecol. 2024 Jan 4. doi: 10.1097/AOG.0000000000005498. Online ahead of print.ABSTRACTRecurrent pregnancy loss (RPL) affects approximately 5% of couples. Although RPL definitions vary across professional societies, an evaluation after a second clinically recognized first-trimester pregnancy loss is recommended. Good quality evidence links parental chromosomal rearrangements, uterine anomalies, and antiphospholipid syndrome (APS) to RPL. In contrast, the relationship between RPL and other endocrine, hematologic, and immunologic disorders or environmental exposures is less clear. Anticoagulant therapy and low-dose asp...
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Viviana de Assis Claudio Schenone Giugni Stephanie T Ros Source Type: research

Evaluation of Recurrent Pregnancy Loss
Obstet Gynecol. 2024 Jan 4. doi: 10.1097/AOG.0000000000005498. Online ahead of print.ABSTRACTRecurrent pregnancy loss (RPL) affects approximately 5% of couples. Although RPL definitions vary across professional societies, an evaluation after a second clinically recognized first-trimester pregnancy loss is recommended. Good quality evidence links parental chromosomal rearrangements, uterine anomalies, and antiphospholipid syndrome (APS) to RPL. In contrast, the relationship between RPL and other endocrine, hematologic, and immunologic disorders or environmental exposures is less clear. Anticoagulant therapy and low-dose asp...
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Viviana de Assis Claudio Schenone Giugni Stephanie T Ros Source Type: research

Evaluation of Recurrent Pregnancy Loss
Obstet Gynecol. 2024 Jan 4. doi: 10.1097/AOG.0000000000005498. Online ahead of print.ABSTRACTRecurrent pregnancy loss (RPL) affects approximately 5% of couples. Although RPL definitions vary across professional societies, an evaluation after a second clinically recognized first-trimester pregnancy loss is recommended. Good quality evidence links parental chromosomal rearrangements, uterine anomalies, and antiphospholipid syndrome (APS) to RPL. In contrast, the relationship between RPL and other endocrine, hematologic, and immunologic disorders or environmental exposures is less clear. Anticoagulant therapy and low-dose asp...
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Viviana de Assis Claudio Schenone Giugni Stephanie T Ros Source Type: research

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update
Conclusion The updated recommendations provide consensus guidance on the management of SLE, combining evidence and expert opinion. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - January 2, 2024 Category: Rheumatology Authors: Fanouriakis, A., Kostopoulou, M., Andersen, J., Aringer, M., Arnaud, L., Bae, S.-C., Boletis, J., Bruce, I. N., Cervera, R., Doria, A., Dörner, T., Furie, R. A., Gladman, D. D., Houssiau, F. A., Ines, L. S., Jayne, D., Kouloumas, M., Kovacs, L., M Tags: ARD, EULAR papers Recommendation Source Type: research

Celiac trunk thrombosis in a patient with antiphospholipid syndrome induced by median arcuate ligament compression: a case presentation and literature review
We report a case of a 29-year-old patient diagnosed with MALS and secondary antiphospholipid syndrome (APS) that developed celiac trunk, common hepatic artery and splenic artery thrombosis. There is not enough information on MALS as a trigger of thrombosis in predisposed patients such as those with APS. However, the case gives rise to suspicion and highlights the diagnostic processes, especially for patients with APS presenting postprandial abdominal pain and weight loss. This review likewise aims at the importance of Doppler ultrasonography as a screening tool and computer tomography (CT) or magnetic resonance (MR) both i...
Source: Rheumatology International - January 1, 2024 Category: Rheumatology Source Type: research

Myocarditis As A Manifestation Of Catastrophic Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) has been well studied and has known association with Libman Sacks endocarditis, accelerated atherosclerotic disease, valvular dysfunction, intracardiac thrombi and myxomas, pulmonary hypertension, and left ventricular dysfunction. Although APS has been associated with lupus myocarditis, there has not been reports of APS myocarditis. Here we present a unique case of bilateral adrenal hemorrhage and myocarditis secondary to APS. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Mica Alex, Modar Alom, Amro Alsaid, Gregory Milligan, Nitin Kabra, David Rawitscher, Aasim Afzal Tags: 088 Source Type: research

886 Non-Criteria Obstetrics Antiphospholipid Syndrome is an independent risk factor for adverse pregnancy outcome
Non-Criteria Obstetric Antiphospholipid Syndrome (NC-OAPS) includes individuals who fit OAPS clinical criteria but not the Sydney laboratory requirements. The aims of the study were to determine the prevalence of NC-OAPS, antiphospholipid antibodies (APLab) profile, pregnancy outcomes among NC-OAPS and long-term thrombotic and obstetric complications. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Shir Luvaton, Anat Rabinovich, Ran Abuhasira, Shayna Miodownik Source Type: research

Placenta microRNA profile of patient with Obstetric Antiphospholipid Syndrome
In this study, we aimed to profile miRNA expressions from placenta tissue of patients with APS. Differentially expressed miRNAs were determined for its targeted genes and pathways. Agilent microarray platform was used to measure placental microRNA expressions between normal placental tissue and those obtained from patients with APS. Differentially expressed miRNAs were detected using GeneSpring GX software 14.2 and sequences were mapped using TargetScan software to generate the predicted target genes. Pathway analysis for the genes was then performed on PANTHER and REACTOME software. Selected miRNAs and their associated ge...
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: M A Mohamad A W Ahmad Asnawi M S Suhiman J Sathar A R Hayati N S Abdul Rahim M A Masri N Abdul Hamid S Nurul Farihah N Mohamad Nor M M Nur Fariha Source Type: research