GSE252972 Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development
Contributors : Nadine M üller-Calleja ; Wolfram Ruf ; Kathrin Saar ; Norbert Hübner ; Jens Posma ; T S NguyenSeries Type : Expression profiling by high throughput sequencingOrganism :Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) areis a major cause for acquired thrombophilia. Here we test the effect of specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) on the activation of monocytes by aPL. NGS data show that aPL-induced proinflammatory and prothrombotic activation of monocytes, but not interferon regulated gene indu...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE252397 Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Contributors : Ruf Wolfram ; Posma Jens ; Nguyen T SonSeries Type : Expression profiling by high throughput sequencingOrganism :Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia. Here we show that specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) prevents the the development of persistent aPL and circulating phospholipid-reactive B1 cells in latent viral infection and lupus prone MRL-lpr mice. NGS mRNA profiling of splenic DC in lupus mice treated with NAPc2 versus saline control...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Predictive factors of psychiatric syndrome in patients with systemic lupus erythematosus
ConclusionsDisease activity reflected by SLEDAI-2K score is a predictor for NPSLE. Antiphospholipid antibodies are associated with mood disorders in SLE. Further separate investigation of neuropsychiatric disorders is needed in order to better comprehend NPSLE’s pathological mechanism. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 21, 2024 Category: Allergy & Immunology Source Type: research
Low recurrent thrombosis rates in single positive antiphospholipid syndrome regardless of type of anticoagulation
Thrombotic antiphospholipid syndrome (TAPS) is characterized by thrombosis and persistently positive tests for antiphospholipid antibodies or lupus anticoagulant (LAC). Triple-positive APS has the highest risk of recurrent thrombosis, but no studies have focused on recurrent thrombosis in patients with single-positive TAPS. We conducted a retrospective cohort study of patients with single-positive TAPS diagnosed at Lifespan Health System, Rhode Island, to determine the rates and risk factors for recurrent thrombosis. (Source: Thrombosis Research)
Source: Thrombosis Research - March 20, 2024 Category: Hematology Authors: Brianna R. Bakow, Lisa Yanek, Mark A. Crowther, Shruti Chaturvedi Source Type: research
Correction: An immunogenomic exome landscape of triple positive primary antiphospholipid patients
Genes & Immunity, Published online: 19 March 2024; doi:10.1038/s41435-024-00261-yCorrection: An immunogenomic exome landscape of triple positive primary antiphospholipid patients (Source: Genes and Immunity)
Source: Genes and Immunity - March 19, 2024 Category: Genetics & Stem Cells Authors: A. Guffroy L. Jacquel Y. Seeleuthner N. Paul V. Poindron F. Maurier V. Delannoy A. C. Voegeli P. Zhang B. Nespola A. Molitor M. J. Apithy P. Soulas-Sprauel T. Martin R. E. Voll S. Bahram V. Gies J. L. Casanova A. Cobat B. Boisson R. Carapito A. S. Korgano Source Type: research
Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
A diagnostic performance study of the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for patients with antiphospholipid syndrome from the Antiphospholipid Syndrome Chinese Collaborative cohort presenting with suspected antiphospholipid syndrome
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 18, 2024 Category: Rheumatology Authors: Qingyi Lu,
Yuzhou Gan,
Zhongqiang Yao,
Chun Li Tags: Letters Source Type: research
Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors  but has lower risk with alcohol intake
ConclusionUsing a very large database, we found new associations between AR and many comorbid conditions, including many inflammatory and chronic degenerative diseases in addition to the known risk factors.Graphical AbstractAortic regurgitation is associated with cardiovascular risk factors, race, and numerous autoimmune diseases. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2024 Category: Cardiology Source Type: research
Management of cerebrospinal fluid rhinorrhea as a rare complication of antiphospholipid syndrome
CONCLUSION: CSF rhinorrhea is uncommon and never previously reported associated with SVC thrombosis induced by antiphospholipid syndrome. A combination of endovascular techniques and surgical repair is recommended for this challenging presentation.PMID:38468657 | PMC:PMC10927183 | DOI:10.25259/SNI_32_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - March 12, 2024 Category: Neurosurgery Authors: Elissa Xian Joel Hardman Geoffrey Parker Arjuna Nirmalananda Source Type: research
