A case of primary pulmonary angiosarcoma arising from tuberculous scar with fatal capillary bleeding
Angiosarcoma metastasized to a skin scar of chest incision. Key Clinical MessageThe etiology of primary pulmonary angiosarcoma is still unknown. Here we report a case of primary pulmonary angiosarcoma originated from a tuberculous scar and presented as aggressive deterioration with uncontrolled bleeding from capillaries with angiodysplasia. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 11, 2024 Category: General Medicine Authors: Minghui Wang,
Xin Zhang,
Hongni Jiang Tags: CASE REPORT Source Type: research
Propranolol monotherapy in angiosarcoma - A window-of-opportunity study (PropAngio)
Angiosarcoma is a rare and aggressive cancer of the endothelial cells. Propranolol, a non-selective β-blocker, was able to initiate apoptosis in angiosarcoma cell lines and its anti-tumor activity has been described in several case reports. The aim of this trial was to prospectively evaluate the anti-tumor activity of propranolol monotherapy in patients with angiosarcoma before proceeding to stan dard of care treatment. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Alaa Embaby, Kimberley M. Heinhuis, Nikki S. IJzerman, Anne Miek Koenen, Stephanie van der Kleij, Ingrid Hofland, Hester van Boven, Joyce Sanders, Winette T.A. van der Graaf, Rick L. Haas, Alwin D.R. Huitema, Winan J. van Houdt, Neeltje Steeghs Tags: Original Research Source Type: research
Ambient ultraviolet radiation is associated with cutaneous angiosarcoma incidence in the United States, 1992 −2020
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 1, 2024 Category: Dermatology Authors: Emmanuel Ike, Jim Z. Mai, Michael R. Sargen, Sara J. Schonfeld, Elizabeth K. Cahoon Source Type: research
Ambient UV radiation is associated with cutaneous angiosarcoma incidence in the United States, 1992 to 2020
To the Editor: Cutaneous angiosarcoma (cAS) is an aggressive cancer of lymphatic/vascular endothelial origin that most frequently occurs on the head and neck and among non-Hispanic white individuals. Risk factors for angiosarcoma include radiotherapy, chronic immunosuppression, chronic lymphedema, germline pathogenic variation in the POT1 gene, and exposure to exogenous toxins.1-3 Prior studies of cAS occurring on chronically sun-exposed skin of the head/neck have demonstrated an UV radiation (UVR) mutational signature,4 but epidemiologic studies directly examining UVR levels and cAS incidence are lacking. (Source: Journal...
Source: Journal of the American Academy of Dermatology - March 1, 2024 Category: Dermatology Authors: Emmanuel Ike, Jim Z. Mai, Michael R. Sargen, Sara J. Schonfeld, Elizabeth K. Cahoon Tags: Research letter Source Type: research
Propranolol monotherapy in angiosarcoma – A window-of-opportunity study (PropAngio)
Angiosarcoma is a rare and aggressive cancer of the endothelial cells. Propranolol, a non-selective β-blocker, was able to initiate apoptosis in angiosarcoma cell lines and its anti-tumor activity has been described in several case reports. The aim of this trial was to prospectively evaluate the anti-tumor activity of propranolol monotherapy in patients with angiosarcoma before proceeding to stan dard of care treatment. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Alaa Embaby, Kimberley M. Heinhuis, Nikki S. IJzerman, Anne Miek Koenen, Stephanie van der Kleij, Ingrid Hofland, Hester van Boven, Joyce Sanders, Winette T.A. van der Graaf, Rick L. Haas, Alwin D.R. Huitema, Winan J. van Houdt, Neeltje Steeghs Tags: Original research Source Type: research
Successful resection of a primary angiosarcoma of the azygos vein: A case report
Chest computed tomography demonstrated neoplastic lesion from the azygos vein to the superior vena cava. The radiological differential diagnosis suggested angiosarcoma or malignant lymphoma. AbstractA 63-year-old woman was admitted to our department for the investigation of superior vena cava (SVC) syndrome. Computed tomography revealed an azygos tumor extending into the SVC. Video-assisted thoracic surgery (VATS) was performed to remove the distal end of the azygos vein in the left lateral position, followed by complete resection of the entire tumor under median sternotomy in the supine position. The histological diagnosi...
Source: Thoracic Cancer - February 18, 2024 Category: Cancer & Oncology Authors: Shinya Kohmaru,
Yuichi Saito,
Masahiro Urata,
Tomohiro Imazuru,
Koji Saito,
Tomoki Shimokawa,
Yukinori Sakao Tags: CASE REPORT Source Type: research
Case Report: A Rare Case of Primary Angiosarcoma of the Cervix with a Literature Review
(Source: International Journal of Womens Health)
Source: International Journal of Womens Health - February 12, 2024 Category: OBGYN Tags: International Journal of Women's Health Source Type: research
Cancers, Vol. 16, Pages 688: Scalp Irradiation with 3D-Milled Bolus: Initial Dosimetric and Clinical Experience
Conclusions: To our knowledge, this is the first study to report the clinical outcomes for patients with scalp malignancies treated with the combination of VMAT and a 3D-milled bolus. This technique resulted in favorable clinical outcomes and an acceptable toxicity profile in comparison with historic controls and warrants further investigation in a larger prospective study. (Source: Cancers)
Source: Cancers - February 6, 2024 Category: Cancer & Oncology Authors: Khaled Dibs Emile Gogineni Sachin M. Jhawar Sujith Baliga John C. Grecula Darrion L. Mitchell Joshua Palmer Karl Haglund Therese Youssef Andraos Wesley Zoller Ashlee Ewing Marcelo Bonomi Priyanka Bhateja Gabriel Tinoco David Liebner James W. Rocco Matthew Tags: Article Source Type: research
Combining nanoparticle albumin-bound paclitaxel with camrelizumab in advanced soft tissue sarcoma: activity, safety, and future perspectives
Conclusion: Nab-paclitaxel plus camrelizumab exhibited modest activity and mild toxicity in treating epithelioid sarcoma, angiosarcoma, and fibrosarcoma. The overall effectiveness of this treatment regimen for advanced STS is relatively low. Further research on combining nab-paclitaxel with effective drugs, including chemotherapy and targeted agents, for these specific STS subtypes is needed. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
Angiosarcoma of gallbladder, a literature review
ConclusionDespite the unavailability of convincing data, histological and immunohistochemical analyses play a major role in the diagnosis of gallbladder angiosarcoma. Nevertheless, more comprehensive clinical studies are required to provide universal guidelines for the treatment and diagnosis of angiosarcoma of the gallbladder. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 31, 2024 Category: General Medicine Source Type: research
Primary angiosarcoma of the Pancreas - A case Report and review of the literature
CONCLUSIONS: Pancreatic angiosarcomas are very rare and prone to misdiagnosis. The formation of a more demarcated but high-grade tumour with necrosis is a feature that distinguishes angiosarcomas from ordinary carcinomas of this organ. Pathologic diagnosis is also highly challenging closely resembling undifferentiated carcinomas. Angiosarcomas are highly aggressive when they occur in the pancreas. Prompt diagnosis at an early stage is crucial as surgery with curative intent serves as the primary treatment approach.PMID:38265358 | DOI:10.1080/00015458.2024.2309718 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - January 24, 2024 Category: Surgery Authors: Emre Bozkurt Samet Yigman Volkan Adsay Bengi Gurses Gurkan Tellioglu Orhan Bilge Source Type: research
Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft Tissue Sarcomas: Clinical Outcomes and Biological Correlates
CONCLUSIONS: The combination of eribulin and pembrolizumab demonstrated promising activity in LPS and angiosarcoma.PMID:38236580 | DOI:10.1158/1078-0432.CCR-23-2250 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 18, 2024 Category: Cancer & Oncology Authors: Candace L Haddox Michael J Nathenson Emanuele Mazzola Jia-Ren Lin Joanna Baginska Allison Nau Jason L Weirather Edwin Choy Adrian Marino-Enriquez Jeffrey A Morgan Gregory M Cote Priscilla Merriam Andrew J Wagner Peter K Sorger Sandro Santagata Suzanne Geo Source Type: research
Neoadjuvant Reirradiation for Radiotherapy Associated Angiosarcoma of the Breast
CONCLUSIONS: Our institutional analysis suggests excellent local control and survival outcomes for RAASB treated with surgery, neoadjuvant hyperfractionated reirradiation, and taxol based chemotherapy. However, major wound complications represent a major challenge with this approach. Future studies should consider how best to improve the therapeutic ratio while maintaining high rates of control and survival.PMID:38191096 | DOI:10.1016/j.ijrobp.2023.12.050 (Source: Cancer Control)
Source: Cancer Control - January 8, 2024 Category: Cancer & Oncology Authors: Wafa Asha Zahraa Al-Hilli Risal Djohan G Thomas Budd Elizabeth Obi Erica Fleming-Hall Kailin Yang Stephen Grobmyer Sheen Cherian Rahul Tendulkar Chirag Shah Source Type: research
Neoadjuvant Reirradiation for Radiotherapy Associated Angiosarcoma of the Breast
We present our modern institutional outcomes in managing RAASB with incorporation of neoadjuvant hyperfractionated reirradiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 6, 2024 Category: Radiology Authors: Wafa Asha, Zahraa Al-Hilli, Risal Djohan, G. Thomas Budd, Elizabeth Obi, Erica Fleming-Hall, Kailin Yang, Stephen Grobmyer, Sheen Cherian, Rahul Tendulkar, Chirag Shah Tags: Brief Report Source Type: research
Neoadjuvant Reirradiation for Radiation Therapy –Associated Angiosarcoma of the Breast
We present our modern institutional outcomes in managing RAASB with incorporation of neoadjuvant hyperfractionated reirradiation. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 6, 2024 Category: Radiology Authors: Wafa Asha, Zahraa Al-Hilli, Risal Djohan, G. Thomas Budd, Elizabeth Obi, Erica Fleming-Hall, Kailin Yang, Stephen Grobmyer, Sheen Cherian, Rahul Tendulkar, Chirag Shah Tags: Brief Report Source Type: research
