Ambient UV radiation is associated with cutaneous angiosarcoma incidence in the United States, 1992 to 2020

To the Editor: Cutaneous angiosarcoma (cAS) is an aggressive cancer of lymphatic/vascular endothelial origin that most frequently occurs on the head and neck and among non-Hispanic white individuals. Risk factors for angiosarcoma include radiotherapy, chronic immunosuppression, chronic lymphedema, germline pathogenic variation in the POT1 gene, and exposure to exogenous toxins.1-3 Prior studies of cAS occurring on chronically sun-exposed skin of the head/neck have demonstrated an UV radiation (UVR) mutational signature,4 but epidemiologic studies directly examining UVR levels and cAS incidence are lacking.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research