Ambient UV radiation is associated with cutaneous angiosarcoma incidence in the United States, 1992 to 2020
To the Editor: Cutaneous angiosarcoma (cAS) is an aggressive cancer of lymphatic/vascular endothelial origin that most frequently occurs on the head and neck and among non-Hispanic white individuals. Risk factors for angiosarcoma include radiotherapy, chronic immunosuppression, chronic lymphedema, germline pathogenic variation in the POT1 gene, and exposure to exogenous toxins.1-3 Prior studies of cAS occurring on chronically sun-exposed skin of the head/neck have demonstrated an UV radiation (UVR) mutational signature,4 but epidemiologic studies directly examining UVR levels and cAS incidence are lacking.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Emmanuel Ike, Jim Z. Mai, Michael R. Sargen, Sara J. Schonfeld, Elizabeth K. Cahoon Tags: Research letter Source Type: research
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