The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
Cell Host Microbe. 2024 Apr 15:S1931-3128(24)00112-4. doi: 10.1016/j.chom.2024.03.012. Online ahead of print.ABSTRACTKaposi sarcoma (KS) is the most common cancer in persons living with HIV. It is caused by KS-associated herpesvirus (KSHV). There exists no animal model for KS. Pronuclear injection of the 170,000-bp viral genome induces early-onset, aggressive angiosarcoma in transgenic mice. The tumors are histopathologically indistinguishable from human KS. As in human KS, all tumor cells express the viral latency-associated nuclear antigen (LANA). The tumors transcribe most viral genes, whereas endothelial cells in other...
Source: Cell Host and Microbe - April 23, 2024 Category: Microbiology Authors: Sang-Hoon Sin Anthony B Eason Yongbaek Kim Johann W Schneider Blossom Damania Dirk P Dittmer Source Type: research
Sustained activation of the FGF1-MEK-ERK pathway inhibits proliferation, invasion and migration and enhances radiosensitivity in mouse angiosarcoma cells
This study aims to clarify the FGF1 mutant mechanism of action using ISOS-1 mouse angiosarcoma cells. The wild-type FGF1 or FGF1 mutant was added to ISOS-1 cells and cultured, evaluating cell numbers over time. The invasive and migratory capacity of ISOS-1 cells was assessed by transwell analysis. ISOS-1 cell radiosensitivity was assessed by colony formation assay after X-ray irradiation. To examine whether mitogen-activated protein kinase (MEK) inhibitor counteracts the FGF1 mutant effects, a combination of MEK inhibitor and FGF1 mutant was added to ISOS-1 cells and cultured. The FGF1 mutant was observed to inhibit ISOS-1...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Taichi Miura Junko Kado Kazuma Ashisuke Mikio Masuzawa Fumiaki Nakayama Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Hepatic and splenic angiosarcoma resection using da Vinci technology: A case report
Asian J Surg. 2024 Apr 9:S1015-9584(24)00617-1. doi: 10.1016/j.asjsur.2024.03.190. Online ahead of print.NO ABSTRACTPMID:38599974 | DOI:10.1016/j.asjsur.2024.03.190 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Hai-Tao Jiang Source Type: research
Hepatic and splenic angiosarcoma resection using da Vinci technology: A case report
Asian J Surg. 2024 Apr 9:S1015-9584(24)00617-1. doi: 10.1016/j.asjsur.2024.03.190. Online ahead of print.NO ABSTRACTPMID:38599974 | DOI:10.1016/j.asjsur.2024.03.190 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Hai-Tao Jiang Source Type: research
Primary Epithelioid Angiosarcoma of the Jejunal Mesentery Causing Abdominal Bleeding: Case Report and Literature Review
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - April 10, 2024 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging
CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.PMID:38591750 | DOI:10.1080/01676830.2024.2331718 (Source: Orbit)
Source: Orbit - April 9, 2024 Category: Opthalmology Authors: Magne Stridh Ulf Dahlstrand Magdalena Naumovska Karl Engelsberg Bodil Gesslein Rafi Sheikh Aboma Merdasa Malin Malmsj ö Source Type: research
