Efficacy and Safety of Transitioning to Lemborexant from Z-drug, Suvorexant, and Ramelteon in Japanese Insomnia Patients: An Open-label, Multicenter Study
ConclusionsDirect transition to LEM may be a valid treatment option for patients with insomnia who are dissatisfied with current treatment.Trial RegistrationClinicalTrials.gov identifier, NCT04742699. (Source: Advances in Therapy)
Source: Advances in Therapy - March 9, 2024 Category: Drugs & Pharmacology Source Type: research
Prediction of herb –drug interaction between hyperforin and sedative hypnotics (zolpidem, alprazolam, and midazolam) using physiologically-based pharmacokinetic modeling
ConclusionsThese findings emphasize the importance of careful monitoring and dose adjustments when using hyperforin and sedative hypnotics together. This study provided insights into co-administration of hyperforin and sedative hypnotics, facilitating the safe and effective use of these medications. Based on these results, it is necessary to know the possibility of safer drug combination, and to conduct clinical research and verification on this. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 24, 2024 Category: Cytology Source Type: research
Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery
CONCLUSION: Stroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post-stroke sleep disturbances, indicating its potential to promote stroke recovery.PMID:38380702 | DOI:10.1111/cns.14637 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Zhi-Gang Zhong Gui-Jin Tao Shu-Mei Hao Hui Ben Wei-Min Qu Feng-Yan Sun Zhi-Li Huang Mei-Hong Qiu Source Type: research
Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery
CONCLUSION: Stroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post-stroke sleep disturbances, indicating its potential to promote stroke recovery.PMID:38380702 | PMC:PMC10880125 | DOI:10.1111/cns.14637 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 21, 2024 Category: Neuroscience Authors: Zhi-Gang Zhong Gui-Jin Tao Shu-Mei Hao Hui Ben Wei-Min Qu Feng-Yan Sun Zhi-Li Huang Mei-Hong Qiu Source Type: research
Speech recovery after single-dose zolpidem in two minimally conscious patients with severe traumatic brain injuries: a case report
CONCLUSION: The patients demonstrated improved cognition on Coma Recovery Scale-Revised assessment after ingesting zolpidem. In particular, speech was substantially restored as one patient recovered functional communication and both demonstrated intelligible verbalizations for the first-time post-injuries following zolpidem. Overall, evidence is limited regarding the underlying mechanisms of various cognitive improvements in zolpidem response although studies incorporating neuroimaging are promising. The outcomes and similarities between these cases contribute to the current literature and highlight the need for rigorous s...
Source: Brain Injury - February 3, 2024 Category: Neurology Authors: Yi Zhou Kathryn A Altonji Ashley Kakkanatt Brian D Greenwald Source Type: research
Meaningful Within-Patient Change in Subjective Total Sleep Time in Patients with Insomnia Disorder: An Analysis of the Sleep Diary Questionnaire Using Data from Open-Label and Phase III Clinical Trials
ConclusionIncreasing sTST is an important treatment outcome for people with insomnia. An increase in sleep time of approximately 55 min is meaningful to patients.Clinical Trials RegistrationNCT03056053 (17 February 2017) and NCT03545191 (4 June 2018). (Source: Pharmaceutical Medicine)
Source: Pharmaceutical Medicine - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
Enzymatic Synthesis of Indole-Based Imidazopyridine using α-Amylase
In this study, we have successfully developed a biocatalytic process for synthesizing indole-based imidazo[1,2-a]pyridine derivatives using the α-amylase enzyme catalyzed Groebke-Blackburn-Bienayme (GBB) multicomponent reaction of 2-aminopyridine, indole-3-carboxaldehyde, and isocyanide. The generality and robustness of this protocol were shown by synthesizing differently substituted indole-based imidazo[1,2-a]pyridines in good isolated yields. Furthermore, to make α-amylase a reusable catalyst for GBB multicomponent reaction, it was immobilized onto magnetic metal-organic framework (MOF) materials [Fe3O4@MIL-100(Fe)] an...
Source: Chembiochem - January 27, 2024 Category: Biochemistry Authors: Priya Kamboj Vikas Tyagi Source Type: research
Molecules, Vol. 29, Pages 335: Developing and Evaluating the Greenness of a Reliable, All-in-One Thin-Film Microextraction Protocol for Determining Fentanyl, Methadone, and Zolpidem in Plasma, Urine, and Oral Fluid
iej
This paper proposes an all-in-one microextraction-based protocol capable of determining and quantifying fentanyl, methadone, and zolpidem in plasma, urine, and saliva at concentrations below those required by international regulatory organizations. A homemade thin-film microextraction device featuring an octyl–cyanopropyl stationary phase was coupled with LC-MS/MS. The proposed method was developed and validated according to FDA criteria, providing extraction efficiency values ranging from 26.7% to 76.2% with no significant matrix effects (2.6% to 15.5% signal suppression). The developed protocol prov...
Source: Molecules - January 9, 2024 Category: Chemistry Authors: Krzysztof Gory ński Łukasz Sobczak Dominika Ko łodziej Tags: Article Source Type: research
Risks of Zolpidem among Patients with Chronic Obstructive Pulmonary Disease
Annals of the American Thoracic Society,Volume 21, Issue 1, Page 68-75, January 2024. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - December 29, 2023 Category: Respiratory Medicine Authors: Jason M. Castaneda Travis Hee Wai Laura J. Spece Kevin I. Duan Aristotle Leonhard Matthew F. Griffith Robert Plumley Brian N. Palen Laura C. Feemster David H. Au Lucas M. Donovan Source Type: research
Combining surface ‐enhanced Raman spectroscopy and paper spray mass spectrometry for the identification and confirmation of psychotropic substances in alcoholic beverages
AbstractCriminal practices in which an individual becomes vulnerable and prone to sexual assault after ingesting drinks spiked with doping substances have become a social concern globally. As forensic protocols require a multi-tiered strategy for chemical evidentiary analysis, the backlog of evidence has become a significant problem in the community. Herein, a fast, sensible, and complementary dual analytical methodology was developed using a single commercial paper substrate for surface-enhanced Raman spectroscopy (SERS) and paper spray mass spectrometry (PS-MS) analysis to identify psychotropic substances added to alcoho...
Source: Journal of Mass Spectrometry - December 26, 2023 Category: Chemistry Authors: Marina Jurisch,
Cristiano Fantini,
Rodinei Augusti,
Mariana Ramos Almeida Tags: RESEARCH ARTICLE Source Type: research
Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder
CONCLUSIONS: Both doxepin and zolpidem were found to be effective in improving sleep quality, but the effects exhibited different patterns. Doxepin improved executive function more effectively than zolpidem in patients with insomnia disorder.PMID:38123719 | DOI:10.1007/s11325-023-02972-4 (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Sleep Medicine Authors: Zhenghe Yu Li Han Pan Yan Wenjuan Liu Lishan Ren You Xu Lili Yang Lisha Ma Yi Liu Shengdong Wang Source Type: research
Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder
CONCLUSIONS: Both doxepin and zolpidem were found to be effective in improving sleep quality, but the effects exhibited different patterns. Doxepin improved executive function more effectively than zolpidem in patients with insomnia disorder.PMID:38123719 | DOI:10.1007/s11325-023-02972-4 (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Sleep Medicine Authors: Zhenghe Yu Li Han Pan Yan Wenjuan Liu Lishan Ren You Xu Lili Yang Lisha Ma Yi Liu Shengdong Wang Source Type: research
Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder
ConclusionsBoth doxepin and zolpidem were found to be effective in improving sleep quality, but the effects exhibited different patterns. Doxepin improved executive function more effectively than zolpidem in patients with insomnia disorder. (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Respiratory Medicine Source Type: research
Gender differences in spontaneous adverse event reports associated with zolpidem in South Korea, 2015 –2019
Conclusion: For several AEs associated with zolpidem, gender-based reporting disparities were evident. Notably, women exhibited a higher susbeptibility to somnambulism, potentially serious adverse effects of zolpidem. This underscores the need for further investigation into the underlying factors influencing these gender-specific reporting patterns. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Source Type: research
