Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of Continuity of the Problem in the Post-Pandemic Period
Curr Neuropharmacol. 2023 Sep 20. doi: 10.2174/1570159X21666230920123401. Online ahead of print.ABSTRACTZolpidem is a non-benzodiazepine hypnotic drug that works as a positive modulator of Gamma-Amino Butyric Acid-A (GABA-A) receptors, with high selectivity for α1 subunits. Given this selective binding, the drug has a strong hypnotic activity. Social isolation during the SARS-CoV-2 pandemic has contributed to increased rates of anxiety, depression, and insomnia. As a result, studies have pointed to a possible increase in the indiscriminate use of drugs with sedative effects, such as Zolpidem, during the pandemic. The aim ...
Source: Current Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Wesley Dawison de Lima Michael Douglas da Silva Eurico de Souza Costa Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Jos é Rodolfo Lopes de Paiva Cavalcanti Fausto Pierdon á Guzen Source Type: research
Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of Continuity of the Problem in the Post-Pandemic Period
Curr Neuropharmacol. 2023 Sep 20. doi: 10.2174/1570159X21666230920123401. Online ahead of print.ABSTRACTZolpidem is a non-benzodiazepine hypnotic drug that works as a positive modulator of Gamma-Amino Butyric Acid-A (GABA-A) receptors, with high selectivity for α1 subunits. Given this selective binding, the drug has a strong hypnotic activity. Social isolation during the SARS-CoV-2 pandemic has contributed to increased rates of anxiety, depression, and insomnia. As a result, studies have pointed to a possible increase in the indiscriminate use of drugs with sedative effects, such as Zolpidem, during the pandemic. The aim ...
Source: Current Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Wesley Dawison de Lima Michael Douglas da Silva Eurico de Souza Costa Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Jos é Rodolfo Lopes de Paiva Cavalcanti Fausto Pierdon á Guzen Source Type: research
Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
ConclusionExposure to alcohol spiked with midazolam or zolpidem appears to exacerbate neurological deficits, inflammation, oxidative stress, and organ damage. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 9, 2023 Category: Forensic Medicine Source Type: research
Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder
Sleep disturbance is commonly reported among individuals meeting criteria for cannabis use disorder (CUD), and cannabis users frequently report sleep disturbance as a contributor to failed quit attempts. The purpose of this study was to measure sleep in individuals enrolled in treatment for CUD, and to determine whether use of hypnotic medication during treatment increased abstinence rates. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - October 4, 2023 Category: Addiction Authors: Dustin C. Lee, Nicolas J. Schlienz, Evan S. Herrman, Erin L. Martin, Jeannie Leoutsakos, Alan J. Budney, Michael T. Smith, D. Andrew Tompkins, Aiden J. Hampson, Ryan Vandrey Source Type: research
Severe chronic abuse of zolpidem for over 10 years: a case report and review of similar cases
ConclusionChronic abuse of zolpidem can cause dependence, withdrawal symptoms, and abuse. High doses can lead to extreme cravings and dependence. Physicians must manage the withdrawal process. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - September 27, 2023 Category: Psychiatry Source Type: research
Patients Using Benzodiazepines Found at Low Risk of Long-Term Use, Unsafe Doses
Most people who received prescriptions for benzodiazepines and related drugs were not long-term users and did not escalate to higher-than-recommended doses, according to a large population-based longitudinalstudy inAJP in Advance.Benzodiazepine receptor agonists (BZRAs), which include benzodiazepines and the so-called “Z-drugs” (zopiclone, eszopiclone, zaleplon, and zolpidem), are the most commonly used drugs for treating insomnia and anxiety. However, because people may build up a tolerance to the drugs and can abuse them, many countries have sought to restrict their prescription. In 2020, the Food and Drug Administra...
Source: Psychiatr News - September 25, 2023 Category: Psychiatry Tags: anxiety benzodiazepine prescriptions Benzodiazepine receptor agonists benzodiazepines insomnia Thomas Rosenqvist Z drugs Source Type: research
Treatment of insomnia in myasthenia gravis —A prospective study on non-benzodiazepine hypnotics in the treatment of myasthenia gravis patients with insomnia
ConclusionNon-benzodiazepine hypnotics are safe and effective for stable MG patients who need insomnia treatment. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats
ConclusionsOverall, these findings support the establishment of pharmaco-EEG “signatures” for identifying subtype-selective GABAA modulatorsin vivo. (Source: Psychopharmacology)
Source: Psychopharmacology - August 22, 2023 Category: Psychiatry Source Type: research
Trajectories of Benzodiazepine Use among Older Adults from a Concordance-with-Guidelines Perspective: A Nationwide Cohort Study
ConclusionsConcordance with guidelines varied over time during benzodiazepine use in older adults. A third of these adults will hypothetically follow one of the identified non-guideline-concordant trajectories, consisting of initial and/or late non-guideline concordance. This was associated with modifiable and nonmodifiable factors that clinicians should be aware of for tailoring the monitoring of patients. (Source: Drugs and Aging)
Source: Drugs and Aging - August 8, 2023 Category: Geriatrics Source Type: research
Immediate Postoperative Zolpidem Use Increases Risk of Falls and Implant Complication Rates Following Total Hip Arthroplasty: A Retrospective Case-Control Analysis
Zolpidem is the most widely used hypnotic in the United States and has known side effects. However, the morbidity of zolpidem use following total hip arthroplasty (THA) is not well-defined. Thus, the aim of this study was to assess the effects that zolpidem use has on medical and implant complications, falls, lengths of stay, and medical utilizations following THA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - August 8, 2023 Category: Orthopaedics Authors: Kevin L. Mekkawy, Hugo C. Rodriguez, Raul G. Gosthe, Arturo Corces, Martin W. Roche Source Type: research
Insomnia Management: A Review and Update
J Fam Pract. 2023 Jul;72(6 Suppl):S31-S36. doi: 10.12788/jfp.0620.ABSTRACTInsomnia is a distinct disorder that is common, yet underrecognized and undertreated in primary care. Treating insomnia has been shown to improve outcomes, including reduced risk of developing cardiovascular and mental health disorders. Insomnia is influenced by the brain's regulation of sleep and wake, which are mutually exclusive events. Insomnia should be treated as a distinct condition, even when occurring with a comorbid diagnosis such as depression or anxiety. Clinicians should implement a multimodal approach to insomnia management, including n...
Source: The Journal of Family Practice - August 7, 2023 Category: Practice Management Authors: David P Shaha Source Type: research
A Case of Ovarian Teratoma-Induced N-Methyl-D-Aspartate Receptor Antibody Encephalitis Presenting With Psychosis and Catatonia, Progressing to the Minimally Conscious State and Successfully Treated With Adjunctive Zolpidem
Prim Care Companion CNS Disord. 2023 Aug 1;25(4):22cr03466. doi: 10.4088/PCC.22cr03466.NO ABSTRACTPMID:37549432 | DOI:10.4088/PCC.22cr03466 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - August 7, 2023 Category: Primary Care Authors: David R Spiegel Kripa Ahuja Faith E Reid Shefali Hegde Emily Carbaugh Vivian Tran Steven Forte Elizabeth Strauss Justin Lagbo James Lau Source Type: research
A Case of Ovarian Teratoma-Induced N-Methyl-D-Aspartate Receptor Antibody Encephalitis Presenting With Psychosis and Catatonia, Progressing to the Minimally Conscious State and Successfully Treated With Adjunctive Zolpidem
Prim Care Companion CNS Disord. 2023 Aug 1;25(4):22cr03466. doi: 10.4088/PCC.22cr03466.NO ABSTRACTPMID:37549432 | DOI:10.4088/PCC.22cr03466 (Source: Primary Care)
Source: Primary Care - August 7, 2023 Category: Primary Care Authors: David R Spiegel Kripa Ahuja Faith E Reid Shefali Hegde Emily Carbaugh Vivian Tran Steven Forte Elizabeth Strauss Justin Lagbo James Lau Source Type: research
Insomnia Management: A Review and Update
J Fam Pract. 2023 Jul;72(6 Suppl):S31-S36. doi: 10.12788/jfp.0620.ABSTRACTInsomnia is a distinct disorder that is common, yet underrecognized and undertreated in primary care. Treating insomnia has been shown to improve outcomes, including reduced risk of developing cardiovascular and mental health disorders. Insomnia is influenced by the brain's regulation of sleep and wake, which are mutually exclusive events. Insomnia should be treated as a distinct condition, even when occurring with a comorbid diagnosis such as depression or anxiety. Clinicians should implement a multimodal approach to insomnia management, including n...
Source: The Journal of Family Practice - August 7, 2023 Category: Practice Management Authors: David P Shaha Source Type: research
