Zolpidem Stimulant Effect and Dependence: A Case Report on Intranasal Use
We present the first case of a patient who developed zolpidem dependence, which was associated with the prompt onset of euphoria exclusively following intranasal use. Mr. A was a 51-year-old polydrug abuser with antisocial personality disorder and a physical dependence on zolpidem. Over several years, he consumed 500 mg of the drug daily, usually divided into 30 mg doses, exclusively via the nasal route because unlike the oral administration of the same dose of the drug, intranasal administration induced euphoria. Euphoric effects manifested 3-5 minutes after taking the drug, and pronounced withdrawal symptoms (i.e., profu...
Source: Psychopharmacology Bulletin - April 11, 2024 Category: Psychiatry & Psychology Authors: Branimir Margeti ć Marina Alaber Source Type: research
A direct analysis method using sheath flow probe electrospray ionisation ‐mass spectrometry (sfPESI‐MS) to detect drug residues from fingerprint forensic gel lifts
This study demonstrates the application of an ambient ionisation method, sheath flow probe electrospray ionisation-mass spectrometry (sfPESI-MS), to the direct analysis of gel-lifted fingerprints. A model drug compound (zolpidem) is successfully detected from gel-lifted prints from three different surface types: glass, metal, and paper. The surface activity-based separation associated with probe electrospray approaches is shown to resolve zolpidem ions from background phthalate species, significantly enhancing the response obtained from the gel-lifter. A depletion series experiment shows that the drug residue can be detect...
Source: Drug Testing and Analysis - April 9, 2024 Category: Drugs & Pharmacology Authors: Ayoung Kim,
Paul F. Kelly,
Matthew A. Turner,
James C. Reynolds Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Successful treatment of cranial dystonia using a Zolpidem+Melatonin combination: A video case-series
Cranial dystonias (CrD) are challenging to treat. Oral pharmacotherapy is often sub-optimal, while delicate anatomy and limited availability of skilled botulinum toxin injectors makes this approach risky, and often difficult to access; neurosurgical options e.g. deep brain stimulation, are high-risk in the elderly populations most affected.We observed significant improvement in CrD in 2 patients prescribed Zolpidem/Melatonin combination treatment for insomnia, and therefore trialled this treatment in a further 4 patients with CrD. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 2, 2024 Category: Neurology Authors: Narendrakumar H. Barad, Eoin Mulroy Tags: Clinical short communication Source Type: research
Molecules, Vol. 29, Pages 1480: Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method
This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L−1 of iomeprol, 48.8 μg L−1 of iopromide, 29.9 μg L−1 of gabapentin, 42.0 μg L−1 of caffeine and 82.5 μg L−1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed hi...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Lucia Molnarova Tatana Halesova Daniela Tomesova Marta Vaclavikova Zuzana Bosakova Tags: Article Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking In-vestigations (2017-2022)
CONCLUSION: This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.PMID:38509674 | DOI:10.2174/0118715265274067240223040333 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - March 21, 2024 Category: Infectious Diseases Authors: Aditya Narayan Shivkant Patel Sunil B Baile Surabhi Jain Smriti Sharma Source Type: research
