Speech recovery after single-dose zolpidem in two minimally conscious patients with severe traumatic brain injuries: a case report

CONCLUSION: The patients demonstrated improved cognition on Coma Recovery Scale-Revised assessment after ingesting zolpidem. In particular, speech was substantially restored as one patient recovered functional communication and both demonstrated intelligible verbalizations for the first-time post-injuries following zolpidem. Overall, evidence is limited regarding the underlying mechanisms of various cognitive improvements in zolpidem response although studies incorporating neuroimaging are promising. The outcomes and similarities between these cases contribute to the current literature and highlight the need for rigorous studies in the future to guide zolpidem trials in patient care for those with DOC.PMID:38308526 | DOI:10.1080/02699052.2024.2311342
Source: Brain Injury - Category: Neurology Authors: Source Type: research