GSE264084 Depletion of ribosome biogenesis factors in NPM1-mutant acute myeloid leukemia: Insights into direct consequences of the mutation and implications for treatment
Contributors : Aristi Damaskou ; Rachael Wilson ; Malgorzata Gozdecka ; Muxin Gu ; Maria Eleftheriou ; Eliza Yankova ; Justyna Rak ; George S VassiliouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in the NPM1 gene are found in more than 30% of acute myeloid leukemia (AML) cases. The mutations disrupt a nucleolar localization signal (NoLS) and create a novel nuclear export signal (NES), leading to cytoplasmic displacement of the protein (NPM1c). NPM1c mutations prime hematopoietic progenitors to leukemic transformation, but their precise molecular consequences remain...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE256495 Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia
Contributors : Kevin A Nuno ; Armon Azizi ; Thomas K öhnke ; Caleb A Lareau ; Asiri Ediwirickrema ; M R Corces ; Ansuman T Satpathy ; Ravindra MajetiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRelapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic mechanisms drive relapse in a large proportion of cases. We therefore characterized epigenetic patterns of AML relapse using 26...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE249545 Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia
This study demonstrates that caspase-2 is a major effector of NPM1c+ function. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Venous thromboembolism in patients with acute myeloid leukemia: development of a predictive model
Patients with acute myeloid leukemia (AML) are at increased risk of venous thromboembolic events (VTE). However, thromboprophylaxis is largely underused. (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 17, 2024 Category: Hematology Authors: Mirjana Mitrovic, Nikola Pantic, Zoran Bukumiric, Nikica Sabljic, Marijana Virijevic, Zlatko Pravdic, Mirjana Cvetkovic, Nikola Ilic, Jovan Rajic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic, Jecko Thachil and Darko Antic Tags: Research Source Type: research
Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms
Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis re... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 17, 2024 Category: Research Authors: Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu and Ling Qi Tags: Research Source Type: research
Momelotinib in myelofibrosis
Expert Opin Pharmacother. 2024 Apr 16. doi: 10.1080/14656566.2024.2343780. Online ahead of print.ABSTRACTINTRODUCTION: Myelofibrosis (MF) is a hematologic disease characterized by bone marrow fibrosis, cytopenias, splenomegaly, and constitutional symptoms. Recent years have seen the emergence of novel therapeutic agents, notably ruxolitinib and fedratinib, which target the Janus kinases (JAK) pathway. However, their myelosuppressive effect coupled with the persistence, and even worsening anemia remains a significant challenge, leading usually to treatment discontinuation.AREAS COVERED: This review focuses on Momelotinib (M...
Source: Expert Opinion on Pharmacotherapy - April 16, 2024 Category: Drugs & Pharmacology Authors: Antonella Bruzzese Enrica Antonia Martino Caterina Labanca Francesco Mendicino Eugenio Lucia Virginia Olivito Annamaria Zimbo Valentina Fragliasso Antonino Neri Fortunato Morabito Ernesto Vigna Massimo Gentile Source Type: research
Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
Mol Biol Rep. 2024 Apr 16;51(1):521. doi: 10.1007/s11033-024-09452-2.ABSTRACTAcute myeloid leukaemia (AML) is a complex haematological malignancy characterised by diverse genetic alterations leading to abnormal proliferation of myeloid precursor cells. One of the most significant genetic alterations in AML involves mutations in the FLT3 gene, which plays a critical role in haematopoiesis and haematopoietic homeostasis. This review explores the current understanding of FLT3 gene mutations and isoforms and the importance of the FLT3 protein in AML. FLT3 mutations, including internal tandem duplications (FLT3-ITD) and point m...
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Diana Mace čková Lenka Va ňková Monika Holubov á Pavel Jindra Robin Klieber Eli ška Jandová Pavel Pitule Source Type: research
Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
Mol Biol Rep. 2024 Apr 16;51(1):521. doi: 10.1007/s11033-024-09452-2.ABSTRACTAcute myeloid leukaemia (AML) is a complex haematological malignancy characterised by diverse genetic alterations leading to abnormal proliferation of myeloid precursor cells. One of the most significant genetic alterations in AML involves mutations in the FLT3 gene, which plays a critical role in haematopoiesis and haematopoietic homeostasis. This review explores the current understanding of FLT3 gene mutations and isoforms and the importance of the FLT3 protein in AML. FLT3 mutations, including internal tandem duplications (FLT3-ITD) and point m...
Source: Mol Biol Cell - April 16, 2024 Category: Molecular Biology Authors: Diana Mace čková Lenka Va ňková Monika Holubov á Pavel Jindra Robin Klieber Eli ška Jandová Pavel Pitule Source Type: research
Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia
Leukemia, Published online: 16 April 2024; doi:10.1038/s41375-024-02250-6Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - April 16, 2024 Category: Hematology Authors: Nandita Noronha Chantal Durette Maxime Cahuzac Bianca E Silva Justine Courtois Juliette Humeau Allan Sauvat Marie-Pierre Hardy Krystel Vincent Jean-Philippe Laverdure Jo ël Lanoix Fr édéric Baron Pierre Thibault Claude Perreault Gregory Ehx Source Type: research
A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemia
This study aims to explore the molecular characteristics of ICD in acute myeloid leukemia (... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Fangmin Zhong, Shuyang He, Ni Guo, Luyi Shi, Linlin Zhang, Hua Jin and Guangyao Kong Tags: Research Source Type: research
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
CONCLUSIONS: Our study highlights the importance of considering the gene mutation patterns for the prediction of drug response in AML. It provides a framework for categorizing patients with AML by mutations that enable drug sensitivity prediction.PMID:38619278 | DOI:10.1158/1078-0432.CCR-23-1674 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Guangrong Qin Jin Dai Sylvia Chien Timothy J Martins Brenda Loera Quy H Nguyen Melanie L Oakes Bahar Tercan Boris Aguilar Lauren Hagen Jeannine McCune Richard Gelinas Raymond J Monnat Ilya Shmulevich Pamela S Becker Source Type: research
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
CONCLUSIONS: Our study highlights the importance of considering the gene mutation patterns for the prediction of drug response in AML. It provides a framework for categorizing patients with AML by mutations that enable drug sensitivity prediction.PMID:38619278 | DOI:10.1158/1078-0432.CCR-23-1674 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 15, 2024 Category: Cancer & Oncology Authors: Guangrong Qin Jin Dai Sylvia Chien Timothy J Martins Brenda Loera Quy H Nguyen Melanie L Oakes Bahar Tercan Boris Aguilar Lauren Hagen Jeannine McCune Richard Gelinas Raymond J Monnat Ilya Shmulevich Pamela S Becker Source Type: research
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
CONCLUSIONS: Our study highlights the importance of considering the gene mutation patterns for the prediction of drug response in AML. It provides a framework for categorizing patients with AML by mutations that enable drug sensitivity prediction.PMID:38619278 | DOI:10.1158/1078-0432.CCR-23-1674 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 15, 2024 Category: Cancer & Oncology Authors: Guangrong Qin Jin Dai Sylvia Chien Timothy J Martins Brenda Loera Quy H Nguyen Melanie L Oakes Bahar Tercan Boris Aguilar Lauren Hagen Jeannine McCune Richard Gelinas Raymond J Monnat Ilya Shmulevich Pamela S Becker Source Type: research
