Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2022.281396. Online ahead of print.ABSTRACTNot available.PMID:38618679 | DOI:10.3324/haematol.2022.281396 (Source: Haematologica)
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Agata Gruszczynska Abhishek Maiti Christopher A Miller Sai Mukund Ramakrishnan Daniel C Link Geoffrey L Uy Allegra A Petti Kala Hayes Courtney D DiNardo Farhad Ravandi Timothy J Ley David H Spencer Feng Gao Marina Y Konopleva John S Welch Source Type: research
T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
ConclusionA T-cell mediated killing sensitivity gene-based prognostic score TTKPI showed good accuracy in predicting survival in AML. TTKPI corresponded to functional and immunological features of the tumor microenvironment including checkpoint expression patterns and should be investigated for precision medicine approaches. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 15, 2024 Category: Cancer & Oncology Source Type: research
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
CONCLUSION: Increased expression of ICOS predicted poor outcomes, and ICOS/PD-1 was the optimal combination of ICs to predict outcomes in patients with AML, which might be a potential immune biomarker for designing novel AML therapy.PMID:38615511 | DOI:10.1016/j.imbio.2024.152804 (Source: Immunobiology)
Source: Immunobiology - April 14, 2024 Category: Allergy & Immunology Authors: Shiyi Pan Qinghua Cai Yiqiong Wei Haifeng Tang Yuping Zhang Wei Zhou Tingfen Deng Wenjian Mo Shunqing Wang Caixia Wang Cunte Chen Source Type: research
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
CONCLUSION: Increased expression of ICOS predicted poor outcomes, and ICOS/PD-1 was the optimal combination of ICs to predict outcomes in patients with AML, which might be a potential immune biomarker for designing novel AML therapy.PMID:38615511 | DOI:10.1016/j.imbio.2024.152804 (Source: Immunobiology)
Source: Immunobiology - April 14, 2024 Category: Allergy & Immunology Authors: Shiyi Pan Qinghua Cai Yiqiong Wei Haifeng Tang Yuping Zhang Wei Zhou Tingfen Deng Wenjian Mo Shunqing Wang Caixia Wang Cunte Chen Source Type: research
What is new in acute myeloid leukemia classification?
Blood Res. 2024 Apr 15;59(1):15. doi: 10.1007/s44313-024-00016-8.ABSTRACTRecently, the International Consensus Classification (ICC) and the 5th edition of the World Health Organization classification (WHO2022) introduced diagnostically similar yet distinct approaches, which has resulted in practical confusion. This review compares these classification systems for acute myeloid leukemia (AML), building up on the revised 4th edition of WHO (WHO2016). Both classifications retain recurrent genetic abnormalities as a primary consideration. However, they differ in terms of blast threshold. The ICC mandates a minimum of 10% blast...
Source: Blood Research - April 14, 2024 Category: Hematology Authors: Hee Sue Park Source Type: research
Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Mol Biol Cell - April 14, 2024 Category: Molecular Biology Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research
Role of reactive oxygen species in myelodysplastic syndromes
Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0.ABSTRACTReactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndro...
Source: Cellular and Molecular Biology Letters - April 14, 2024 Category: Biochemistry Authors: Qiangan Jing Chaoting Zhou Junyu Zhang Ping Zhang Yunyi Wu Junyu Zhou Xiangmin Tong Yanchun Li Jing Du Ying Wang Source Type: research
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
CONCLUSION: Increased expression of ICOS predicted poor outcomes, and ICOS/PD-1 was the optimal combination of ICs to predict outcomes in patients with AML, which might be a potential immune biomarker for designing novel AML therapy.PMID:38615511 | DOI:10.1016/j.imbio.2024.152804 (Source: Immunobiology)
Source: Immunobiology - April 14, 2024 Category: Allergy & Immunology Authors: Shiyi Pan Qinghua Cai Yiqiong Wei Haifeng Tang Yuping Zhang Wei Zhou Tingfen Deng Wenjian Mo Shunqing Wang Caixia Wang Cunte Chen Source Type: research
Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia
CONCLUSION: Increased expression of ICOS predicted poor outcomes, and ICOS/PD-1 was the optimal combination of ICs to predict outcomes in patients with AML, which might be a potential immune biomarker for designing novel AML therapy.PMID:38615511 | DOI:10.1016/j.imbio.2024.152804 (Source: Immunobiology)
Source: Immunobiology - April 14, 2024 Category: Allergy & Immunology Authors: Shiyi Pan Qinghua Cai Yiqiong Wei Haifeng Tang Yuping Zhang Wei Zhou Tingfen Deng Wenjian Mo Shunqing Wang Caixia Wang Cunte Chen Source Type: research
GSE239469 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling [RNA-seq]
Contributors : Liling Wan ; Yiman Liu ; Qinglan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGain-of-function mutations in the chromatin ‘reader’ ENL, identified in AML and Wilms tumor, have been shown to induce aberrant formation of transcriptional condensates in cellular systems. However, the precise role of these mutations and their condensate forming property in tumorigenesis remains unclear. By creating a conditional knock-i n mouse model for the most prevalent ENL mutation, we establish ENL mutant as a bona fide oncogenic driver of acute myeloid leukemia in vivo. Het...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE239468 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling [ChIP-seq and CUT & Tag]
Contributors : Liling Wan ; Yiman Liu ; Qinglan LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGain-of-function mutations in the chromatin ‘reader’ ENL, identified in AML and Wilms tumor, have been shown to induce aberrant formation of transcriptional condensates in cellular systems. However, the precise role of these mutations and their condensate forming property in tumorigenesis remains unclear. By creating a conditional knock-i n mouse model for the most prevalent ENL mutation, we establish ENL mutant as a bona fide oncogenic driver of acute myeloid leukemi...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Isolation of acute myeloid leukemia blasts from blood using a microfluidic device
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Alexandra Teixeira, Maria Sousa-Silva, Alexandre Chicharo, Kevin Oliveira, Andr é Távora Moura, Adriana Carneiro, Paulina Piairo, Hugo Águas, Belém Sampaio-Marques , José Mariz, Paula Ludovico, Sara Abalde-Cela, Lorena Diéguez, Isabel Castro Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and associated with poor prognosis. Unfortunately, most of the patients that achieve clinical complete remission after... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - April 13, 2024 Category: Chemistry Authors: Alexandra Teixeira Source Type: research
Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02284-5Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Arnon Nagler Myriam Labopin Ryszard Swoboda Thomas Schroeder Rose-Marie Hamladji Laimonas Griskevicius Urpu Salmenniemi Alessandro Rambaldi Stephan Mielke Alexander Kulagin Jakob Passweg Thomas Luft Tobias Gedde-Dahl Edouard Forcade Grzegorz Helbig Matthi Source Type: research
Generation and characterization of the iPS cell line (SYSUSHi001-A) derived from the peripheral blood mononuclear cells (PBMCs) of a 33-year-old patient with acute myeloid leukemia (AML)
Stem Cell Res. 2024 Feb 23;77:103360. doi: 10.1016/j.scr.2024.103360. Online ahead of print.ABSTRACTWe successfully developed an induced pluripotent stem cell (iPSC) line, SYSUSHi001-A, from the peripheral blood mononuclear cells (PBMC) of a patient with Acute Myeloid Leukemia, harboring two genetic mutations (XPO1: c.591-4_591-3dupTT; PALB2: c.3296C > T; p.T1099M). This iPSC line was facilitated through the use of episomal plasmids encoding OCT4, SOX2, KLF4, L-MYC, and human miR-302. The SYSUSHi001-A iPSC line exhibited characteristic embryonic stem cell-like morphology, maintained the XPO1 and PALB2 mutations, express...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Lihua Yuan Mei Xie Yuan Tao Xi Chen Xiaojun Xu Xiaobo Wang Source Type: research
Fucosylation inhibitor 6-alkynylfucose enhances the ATRA-induced differentiation effect on acute promyelocytic leukemia cells
In this study, we investigated the effects of combinations of glycosylation inhibitors with ATRA to achieve better efficiency than ATRA alone. We found that the combination of fucosylation inhibitor 6-alkynylfucose (6AF) and ATRA had an additional effect on cell differentiation, as revealed by expression changes in two differentiation markers, CD11b and CD11c, and significant morphological changes in NB4 APL and HL-60 acute myeloid leukemia (AML) cells. In AAL lectin blot analyses, ATRA or 6AF alone could decrease fucosylation, while their combination decreased fucosylation more efficiently. To clarify the molecular mechan...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Susumu Suzuki Jianwei Liu Yuri Sato Rikuto Miyake Souma Suzuki Yoko Okitsu Tomohiko Fukuda Tomoya Isaji Jianguo Gu Shinichiro Takahashi Source Type: research
