Genetic mutations and immune microenvironment: unveiling the connection to AML prognosis
CONCLUSION: This results implies that distinct genetic mutations may play a role not only in tumor initiation but also in shaping the tumor microenvironment, consequently impacting prognosis.PMID:38687637 | DOI:10.1080/16078454.2024.2346965 (Source: Hematology)
Source: Hematology - April 30, 2024 Category: Hematology Authors: ZhongLi Hu YanLi Yang JiaJia Li ZhongTing Hu Source Type: research
Correlation between HOX11 Gene Expression and Clinical Prognosis of Patients with Acute Leukemia
CONCLUSION: The study suggests the potential of using HOX11 expression as a marker in clinical practice for monitoring acute leukemia prognosis.PMID:38687853 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Ling Li Jie Ma Shuzhen Shen Source Type: research
Genetic mutations and immune microenvironment: unveiling the connection to AML prognosis
CONCLUSION: This results implies that distinct genetic mutations may play a role not only in tumor initiation but also in shaping the tumor microenvironment, consequently impacting prognosis.PMID:38687637 | DOI:10.1080/16078454.2024.2346965 (Source: Hematology)
Source: Hematology - April 30, 2024 Category: Hematology Authors: ZhongLi Hu YanLi Yang JiaJia Li ZhongTing Hu Source Type: research
Correlation between HOX11 Gene Expression and Clinical Prognosis of Patients with Acute Leukemia
CONCLUSION: The study suggests the potential of using HOX11 expression as a marker in clinical practice for monitoring acute leukemia prognosis.PMID:38687853 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Ling Li Jie Ma Shuzhen Shen Source Type: research
Genetic mutations and immune microenvironment: unveiling the connection to AML prognosis
CONCLUSION: This results implies that distinct genetic mutations may play a role not only in tumor initiation but also in shaping the tumor microenvironment, consequently impacting prognosis.PMID:38687637 | DOI:10.1080/16078454.2024.2346965 (Source: Hematology)
Source: Hematology - April 30, 2024 Category: Hematology Authors: ZhongLi Hu YanLi Yang JiaJia Li ZhongTing Hu Source Type: research
GSE260759 Targeting a Lineage-Specific PI3K ɣ/AKT Signaling Module in Acute Myeloid Leukemia Using a Heterobifunctional Degrader Molecule
Contributors : Lois Kelly ; Alexandre Puissant ; Camille LobrySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in non-malignant tissues. This obstacle can be minimized by targeting cancer dependencies driven by proteins with tissue- and/or tumor-restricted expression. Here, we show that in acute myeloid leukemia (AML), suppression of the myeloid-restricted PIK3CG/p110 𝛾-PIK3R5/p101 axis blocks AKT signaling, compromises cell fitness, and sensi...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE243056 A novel t(X;21) (p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in Myelodysplastic Syndromes/Acute Myeloid Leukemias
Series Type : Expression profiling by array ; Genome variation profiling by SNP arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Genome variation profiling by SNP array Homo sapiens Source Type: research
GSE243055 A novel t(X;21) (p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in Myelodysplastic Syndromes/Acute Myeloid Leukemias [Copy number analysis]
In this study we present a thus far undescribed, reciprocal, unbalanced chromosomal translocation between the long arm of chromosome 21 and the short arm of chromosome X, t(X;21)(p11.4;q22.12), in five cases with Myelodysplastic Syndromes and Acute Myeloid Leukemias (MDS/AML). The translocation was isolated or accompanied by one additional change and is not generating a fusion gene. Deletion of RUNX1 at chromosome 21 and of BCOR at chromosome X was shown by Fluorescence In Situ Hybridization (FISH) and Single Nucleotide Polymorphism array (SNPa) analysis. BCOR was downregulated in all cases compared to the normal counterp...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Genome variation profiling by SNP array Homo sapiens Source Type: research
GSE243053 A novel t(X;21) (p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in Myelodysplastic Syndromes/Acute Myeloid Leukemias [Gene expression analysis]
In this study we present a thus far undescribed, reciprocal, unbalanced chromosomal translocation between the long arm of chromosome 21 and the short arm of chromosome X, t(X;21)(p11.4;q22.12), in five cases with Myelodysplastic Syndromes and Acute Myeloid Leukemias (MDS/AML). The translocation was isolated or accompanied by one additional change and is not generating a fusion gene. Deletion of RUNX1 at chromosome 21 and of BCOR at chromosome X was shown by Fluorescence In Situ Hybridization (FISH) and Single Nucleotide Polymorphism array (SNPa) analysis. BCOR was downregulated in all cases compared to the normal counterp...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE222323 DOT1L controls NK cell activation and lineage integrity [ChIP-seq]
In this study, we identify DOT1L as a critical regulator of NK cell activation and lineage integrity. We generated NKp46-conditional DOT1L knockout mice (DOT1L.Ncr1) and observed increased frequencies of ILC1-like cells (CD49b+ CD49a+, CD62L-) and reduced frequencies of NK c ells (CD49b+ CD49a-, CD62L+) in these mice. While the absence of DOT1L increases the sensitivity to TGFβ, the increased expression of CD49a is highly intrinsic and only partially dependent on TGFβ signalling. Functionally, the increased presence of ILC1-like cells in the tumour microenvironment of DOT1L.Ncr1 mice leads to decreased tumour control. O...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE222234 DOT1L controls NK cell maturation and lineage integrity [RNA-seq D5]
Contributor : Sebastian ScheerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn the innate immune system, natural killer (NK) cells represent a highly important subset of cells with utmost importance in the control of transformed cell and tumour inflammation. Previous studies showed that NK cells can convert into ILC1-like cells in a TGF- β-rich tumour microenvironment (TME). In addition, cancer patients with acute myeloid leukemia (AML) or chronic lymphocytic leukemia (CLL) have increased frequencies of ILC1 cells in peripheral blood mononuclear cells (PBMCs), which show reduced p...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE222233 DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2]
In this study, we identify DOT1L as a critical regulator of NK cell activation and lineage integrity. We generated NKp46-conditional DOT1L knockout mice (DOT1L.Ncr1) and observed increased frequencies of ILC1-like cells (CD49b+ CD49a+, CD62L-) and reduced frequencies of NK c ells (CD49b+ CD49a-, CD62L+) in these mice. While the absence of DOT1L increases the sensitivity to TGFβ, the increased expression of CD49a is highly intrinsic and only partially dependent on TGFβ signalling. Functionally, the increased presence of ILC1-like cells in the tumour microenvironment of DOT1L.Ncr1 mice leads to decreased tumour control. O...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE222232 DOT1L controls NK cell maturation and lineage integrity [CUT & TAG]
In this study, we identify DOT1L as a critical regulator of NK cell activation and lineage integrity. We generated NKp46-conditional DOT1L knockout mice (DOT1L.Ncr1) and observed increased frequencies of ILC1-like cells (CD49b+ CD49a+, CD62L-) and reduced frequencies of NK c ells (CD49b+ CD49a-, CD62L+) in these mice. While the absence of DOT1L increases the sensitivity to TGFβ, the increased expression of CD49a is highly intrinsic and only partially dependent on TGFβ signalling. Functionally, the increased presence of ILC1-like cells in the tumour microenvironment of DOT1L.Ncr1 mice leads to decreased tumour control. O...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Longitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia
This study reported height prediction and longitudinal growth changes in Chinese pediatric patients with acute myeloid leukemia (AML) during and after treatment and their associations with outcomes. (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 30, 2024 Category: Pediatrics Authors: Xiaojia Wen, Hongbo He, Ruidong Zhang, Ying Wu, Yuanyuan Zhang, Wei Lin, Jiaole Yu, Jia Fan, Pengli Huang, Jiajia Chen, Wenjing Li, Chunxiu Gong and Huyong Zheng Tags: Research Source Type: research
Kinetics of Recovery of Naive and Memory T Cells in Acute Leukemia Patients after Allogeneic Stem Cell Transplantation Depending on Different GVHD Prophylaxis Regimens
Conclusion: These experimental outcomes contribute to providing the best understanding of immunological events that occur early after transplantation and help in the rational choice of GVHD prophylaxis in patients who will undergo allogeneic transplantation. Our study demonstrated the comparable immunological effects of posttransplant cyclophosphamide and ex vivo T cell depletion and immunological inefficiency of horse ATG for GVHD prevention.PMID:38680716 | PMC:PMC11055426 | DOI:10.18502/ijhoscr.v18i1.14742 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Natalia Popova Mikhail Drokov Yulia Davydova Nikolay Kapranov Vera Vasilieva Irina Galtseva Larisa Kuzmina Elena Parovichnikova Source Type: research
