Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer
Heat shock protein 90 (HSP90) is overexpressed in numerous cancers, promotes the maturation of numerous oncoproteins and facilitates cancer cell growth. Certain HSP90 inhibitors have entered clinical trials. A... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 22, 2024 Category: Nanotechnology Authors: Lejiao Jia, Huatian Yang, Yue Liu, Ying Zhou, Guosheng Li, Qian Zhou, Yan Xu, Zhiping Huang, Feng Ye, Jingjing Ye, Anchang Liu and Chunyan Ji Tags: Research Source Type: research
p53 immunohistochemistry as an ancillary tool for rapid assessment of residual disease in TP53-mutated acute myeloid leukemia and myelodysplastic syndromes
CONCLUSIONS: Our study suggests that p53 IHC can be used as a rapid tool (within 24 hours) to aid in the detection of residual disease that may complement MRD-FC or NGS in cases in which the flow cytometry immunophenotype is equivocal and/or the bone marrow aspirate is suboptimal.PMID:38643353 | DOI:10.1093/ajcp/aqae034 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 21, 2024 Category: Pathology Authors: Nivaz Brar Lauren Lawrence Eula Fung James L Zehnder Peter L Greenberg Gabriel N Mannis Tian Y Zhang Dita Gratzinger Jean Oak Oscar Silva Jason Kurzer Brent Tan Joshua R Menke Sebastian Fernandez-Pol Source Type: research
A rare KMT2A::CBL transcript in an acute monoblastic leukemia patient with an unfavorable outcome
CONCLUSIONS: This report provides novel insights into the leukemogenic potential of the KMT2A::CBL rearrangement and the correlation between gene rearrangements and clinical outcomes.PMID:38643442 | PMC:PMC11033236 | DOI:10.1007/s11033-024-09543-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 21, 2024 Category: Molecular Biology Authors: Jinglei Yu Fengmei Song Mingming Zhang Pingnan Xiao Jingjing Feng Ruimin Hong Yongxian Hu He Huang Guoqing Wei Source Type: research
p53 immunohistochemistry as an ancillary tool for rapid assessment of residual disease in TP53-mutated acute myeloid leukemia and myelodysplastic syndromes
CONCLUSIONS: Our study suggests that p53 IHC can be used as a rapid tool (within 24 hours) to aid in the detection of residual disease that may complement MRD-FC or NGS in cases in which the flow cytometry immunophenotype is equivocal and/or the bone marrow aspirate is suboptimal.PMID:38643353 | DOI:10.1093/ajcp/aqae034 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 21, 2024 Category: Pathology Authors: Nivaz Brar Lauren Lawrence Eula Fung James L Zehnder Peter L Greenberg Gabriel N Mannis Tian Y Zhang Dita Gratzinger Jean Oak Oscar Silva Jason Kurzer Brent Tan Joshua R Menke Sebastian Fernandez-Pol Source Type: research
Interaction of olive oil-based propolis and caffeic acid phenethyl ester with methylprednisolone used in the treatment of human acute myeloid leukemia
CONCLUSIONS: Propolis and its constituents have the potential to serve as effective adjunctive therapies in chemotherapy.PMID:38643306 | DOI:10.1007/s11033-024-09493-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Hamide Dogan A Ata Ozcimen Sibel Silici Source Type: research
Cancers, Vol. 16, Pages 1580: T-Cell Engagers & mdash;The Structure and Functional Principle and Application in Hematological Malignancies
Cancers, Vol. 16, Pages 1580: T-Cell Engagers—The Structure and Functional Principle and Application in Hematological Malignancies
Cancers doi: 10.3390/cancers16081580
Authors:
Paweł Cech
Katarzyna Skórka
Laura Dziki
Krzysztof Giannopoulos
Recent advancements in cancer immunotherapy have made directing the cellular immune response onto cancer cells a promising strategy for the treatment of hematological malignancies. The introduction of monoclonal antibody-based (mAbs) targeted therapy has significantly improved the prognosis for hematological patients. Facing the issues of mAb-based therapies, a ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Pawe ł Cech Katarzyna Sk órka Laura Dziki Krzysztof Giannopoulos Tags: Review Source Type: research
8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia
Leukemia, Published online: 20 April 2024; doi:10.1038/s41375-024-02222-w8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - April 20, 2024 Category: Hematology Authors: Jiamin Guo Ralf Buettner Li Du Zhenlong Li Wei Liu Rui Su Zhenhua Chen Yuan Che Yi Zhang Rui Ma Le Xuan Truong Nguyen Roger E. Moore Pathak Khyatiben Min-Hsuan Chen Pirrotte Patrick Xiwei Wu Guido Marcucci Lili Wang David Horne Jianjun Chen Yanzhong Yang Source Type: research
GSE263911 AML1-ETO and CCND2 overexpression ¬ cooperate to drive acute myeloid leukemia initiation and progression
In conclusion, we confirmed that introduction of the CCND2 gene into the AML/ETO pre-leukemia mice can trigger the development of leukemia. We also confirmed that CCND2 overexpression resulted in the upregulation of the mTOR pathway and inhibiting the pathway may be a therapeutic agent for this subtype of leukemia. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
Validation of mutated < em > CEBPA < /em > bZIP as a distinct prognosis entity in acute myeloid leukemia: a study by the Spanish PETHEMA registry
Haematologica. 2024 Apr 18. doi: 10.3324/haematol.2023.284601. Online ahead of print.ABSTRACTNot available.PMID:38634126 | DOI:10.3324/haematol.2023.284601 (Source: Haematologica)
Source: Haematologica - April 18, 2024 Category: Hematology Authors: Esther Prados De la Torre Josefina Serrano David Mart ínez-Cuadrón Laura Torres Claudia Sargas Rosa Ayala Cristina Bilbao-Sieyro Mar ía Carmen Chillón Mar ía José Larráyoz Elena Soria Clara Aparicio-P érez Juan M Bergua Teresa Bernal Cristina Gil Source Type: research
Validation of mutated < em > CEBPA < /em > bZIP as a distinct prognosis entity in acute myeloid leukemia: a study by the Spanish PETHEMA registry
Haematologica. 2024 Apr 18. doi: 10.3324/haematol.2023.284601. Online ahead of print.ABSTRACTNot available.PMID:38634126 | DOI:10.3324/haematol.2023.284601 (Source: Haematologica)
Source: Haematologica - April 18, 2024 Category: Hematology Authors: Esther Prados De la Torre Josefina Serrano David Mart ínez-Cuadrón Laura Torres Claudia Sargas Rosa Ayala Cristina Bilbao-Sieyro Mar ía Carmen Chillón Mar ía José Larráyoz Elena Soria Clara Aparicio-P érez Juan M Bergua Teresa Bernal Cristina Gil Source Type: research
Validation of mutated < em > CEBPA < /em > bZIP as a distinct prognosis entity in acute myeloid leukemia: a study by the Spanish PETHEMA registry
Haematologica. 2024 Apr 18. doi: 10.3324/haematol.2023.284601. Online ahead of print.ABSTRACTNot available.PMID:38634126 | DOI:10.3324/haematol.2023.284601 (Source: Haematologica)
Source: Haematologica - April 18, 2024 Category: Hematology Authors: Esther Prados De la Torre Josefina Serrano David Mart ínez-Cuadrón Laura Torres Claudia Sargas Rosa Ayala Cristina Bilbao-Sieyro Mar ía Carmen Chillón Mar ía José Larráyoz Elena Soria Clara Aparicio-P érez Juan M Bergua Teresa Bernal Cristina Gil Source Type: research
KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia
Leukemia, Published online: 18 April 2024; doi:10.1038/s41375-024-02244-4KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - April 18, 2024 Category: Hematology Authors: Shinju Iyoda Kenichi Yoshida Kota Shoji Nana Ito Miu Tanaka Yasuhito Nannya Genki Yamato Shinichi Tsujimoto Norio Shiba Yasuhide Hayashi Yusuke Shiozawa Yuichi Shiraishi Kenichi Chiba Ai Okada Hiroko Tanaka Satoru Miyano Yuhki Koga Hiroaki Goto Hiroshi Mo Source Type: research
Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody
Blood Cancer Journal, Published online: 18 April 2024; doi:10.1038/s41408-024-01050-6Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - April 18, 2024 Category: Hematology Authors: Sylwia A. Stefa ńczyk Ilona Hagelstein Martina S. Lutz Stefanie M üller Samuel J. Holzmayer Grace Jarjour Latifa Zekri Jonas S. Heitmann Helmut R. Salih Melanie M ärklin Source Type: research
From code to care: Clinician and researcher perspectives on an optimal therapeutic web portal for acute myeloid leukemia
ConclusionsThis research adds to existing calls for digital platforms for researchers and clinicians to supplement extant modes of communication to streamline research and its dissemination, advance precision medicine, and ultimately improve patient prognosis and care. Findings are applicable to therapeutic web portals more generally, particularly in genomic and translational medicine, and will be of interest to portal end-users, developers, researchers, and policymakers. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Terese Knoppers Source Type: research
KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia
Leukemia. 2024 Apr 18. doi: 10.1038/s41375-024-02244-4. Online ahead of print.NO ABSTRACTPMID:38632314 | DOI:10.1038/s41375-024-02244-4 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Shinju Iyoda Kenichi Yoshida Kota Shoji Nana Ito Miu Tanaka Yasuhito Nannya Genki Yamato Shinichi Tsujimoto Norio Shiba Yasuhide Hayashi Yusuke Shiozawa Yuichi Shiraishi Kenichi Chiba Ai Okada Hiroko Tanaka Satoru Miyano Yuhki Koga Hiroaki Goto Hiroshi Mo Source Type: research
