Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial
Lancet Haematol. 2024 Apr 4:S2352-3026(24)00065-6. doi: 10.1016/S2352-3026(24)00065-6. Online ahead of print.ABSTRACTBACKGROUND: Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear.METHODS: To test salvage chemotherapy before allogeneic HSCT, patients aged between 18 and 75 years with non-favourable-risk acute myeloid leukaemia not in complete remission after first ind...
Source: Cancer Control - April 7, 2024 Category: Cancer & Oncology Authors: Matthias Stelljes Jan Moritz Middeke Gesine Bug Eva-Maria Wagner-Drouet Lutz P M üller Christoph Schmid Stefan W Krause Wolfgang Bethge Edgar Jost Uwe Platzbecker Stefan A Klein J örg Schubert Judith Niederland Martin Kaufmann Kerstin Sch äfer-Eckart M Source Type: research
ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RAR α signaling axis
In this study, acute promyelocytic leukemia NB4 cells before and after ATPR induction were analyzed by whole transcriptome microarray, and the expression of lncRNA CONCR was found to be significantly downregulated. The role of CONCR in ATPR-induced cell differentiation and cycle arrest was explored through overexpression and silencing of CONCR. And then the database was used to predict that CONCR may bind to DEAD/H-Box Helicase 11 (DDX11) protein to further explore the role of CONCR binding to DDX11. The results showed that ATPR could reduce the expression of CONCR, and overexpression of CONCR could reverse the ATPR-induce...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Shen Liu Wenjing Zhan Xiong He Mengjia Hao Wenwen Shen Xiaoyue Zhang Meng Wang Zihan Li Ruirui Hou Ziyao Ou Yubin Feng Feihu Chen Source Type: research
Safety and efficacy of chimeric antigen receptor T-cell therapy for acute myeloid leukemia: A subgroup based meta-analysis
CONCLUSIONS: This meta-analysis highlights the potential of CAR T-cell therapy in AML treatment, especially when integrated with certain prior treatments and conditioning regimens. The findings suggest a higher efficacy in patients with previous hematopoietic cell transplantation and specific conditioning regimens. Further large-scale, randomized trials are essential to confirm these findings and establish CAR T-cell therapy as a standard treatment for AML.PMID:38582045 | DOI:10.1016/j.leukres.2024.107498 (Source: Cell Research)
Source: Cell Research - April 6, 2024 Category: Cytology Authors: Mahmoud M Morsy Ahmed Y Azzam Osman Elamin Adam Elswedy Abdulqadir J Nashwan Source Type: research
Decitabine-cedazuridine as first line in acute myeloid leukaemia ineligible for conventional induction chemotherapy
Bull Cancer. 2024 Apr 5:S0007-4551(24)00081-X. doi: 10.1016/j.bulcan.2024.01.012. Online ahead of print.NO ABSTRACTPMID:38582741 | DOI:10.1016/j.bulcan.2024.01.012 (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Urbain Tauveron-Jalenques Juliette Lambert Source Type: research
