Acute Myeloid Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

[PERSPECTIVES] Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are metabolic enzymes that interconvert isocitrate and 2-oxoglutarate (2OG). Gain-of-function mutations in IDH1 and IDH2 occur in a number of cancers, including acute myeloid leukemia, glioma, cholangiocarcinoma, and chondrosarcoma. These mutations cripple the wild-type activity of IDH and cause the enzymes to catalyze a partial reverse reaction in which 2OG is reduced but not carboxylated, resulting in production of the (R)-enantiomer of 2-hydroxyglutarate ((R)-2HG). (R)-2HG accumulation in IDH-mutant tumors results in profound dysregulation of cellular metabolism. The most...
Source: Cold Spring Harbor perspectives in medicine - May 2, 2024 Category: Research Authors: Gunn, K., Losman, J.-A. Tags: Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities PERSPECTIVES Source Type: research

Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
Opinion statementThe internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 (FLT3-ITD) is the most common mutation observed in approximately 30% of acute myeloid leukemia (AML) patients. It represents poor prognosis due to continuous activation of downstream growth-promoting signaling pathways such as STAT5 and PI3K/AKT. Hence, FLT3 is considered an attractive druggable target; selective small FLT3 inhibitors (FLT3Is), such as midostaurin and quizartinib, have been clinically approved. However, patients possess generally poor remission rates and acquired resistance when FLT3I used alone. Vari...
Source: Current Treatment Options in Oncology - May 2, 2024 Category: Cancer & Oncology Source Type: research

Benzoyl Peroxide Use in Acne Therapy: Evaluating the Association with Acute Myeloid Leukemia Risk
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 2, 2024 Category: Dermatology Authors: Jesse Veenstra, David Ozog Source Type: research

Comparison of older related vs younger unrelated donors for old recipients of allogeneic hematopoietic cell transplantation with AML or MDS- a large single center analysis
The introduction of reduced-intensity conditioning regimens has made allogeneic hematopoietic cell transplantation (alloHSCT) feasible for elderly recipients, aged well into their 70s1. In particular, myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), which are conventionally diseases of the elderly (median age at diagnosis ∼ 68 years for AML and ∼70 years for MDS), have become the most common disease indications for alloHCT, comprising 65-70% of all alloHCTs performed worldwide. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - May 2, 2024 Category: Hematology Authors: Haesook T. Kim, Vincent T Ho, Sarah Nikiforow, Corey Cutler, John Koreth, Roman M Shapiro, Mahasweta Gooptu, Rizwan Romee, Catherine J. Wu, Joseph H. Antin, Jerome Ritz, Robert J Soiffer Source Type: research

Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03778-0. Online ahead of print.ABSTRACTIn hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis for many patients with AML remains poor. Recently, immunotherapy has emerged as a promising approach to improve outcomes by augmenting existing treatments. Natural killer (NK) cells, a subset of innate lymphoid cells, have garnered attention fo...
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Yuta Kaito Yoichi Imai Source Type: research

Correlation between HOX11 Gene Expression and Clinical Prognosis of Patients with Acute Leukemia
CONCLUSION: The study suggests the potential of using HOX11 expression as a marker in clinical practice for monitoring acute leukemia prognosis.PMID:38687853 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Ling Li Jie Ma Shuzhen Shen Source Type: research

Clinical features of immature leukemias in children
Int J Hematol. 2024 Apr 30. doi: 10.1007/s12185-024-03771-7. Online ahead of print.ABSTRACTEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL), mixed phenotypic acute leukemia (MPAL), and acute myeloid leukemia with minimal differentiation (AML-M0) all originate from immature hematopoietic progenitor cells and have a poor prognosis. We investigated the clinical characteristics of these immature leukemias in 17 children (ETP-ALL: 8, MPAL: 5, AML-M0: 4) at seven institutions. Clinical and laboratory findings were comparable across disease types. Eleven and six patients received ALL- and AML-oriented induction chemo...
Source: International Journal of Hematology - April 30, 2024 Category: Hematology Authors: Daichi Sajiki Nao Yoshida Hideki Muramatsu Kimiyoshi Sakaguchi Naoko Maeda Norifumi Yokoyama Yuji Miyajima Makito Tanaka Yoshiyuki Takahashi Asahito Hama Source Type: research

Genetic mutations and immune microenvironment: unveiling the connection to AML prognosis
CONCLUSION: This results implies that distinct genetic mutations may play a role not only in tumor initiation but also in shaping the tumor microenvironment, consequently impacting prognosis.PMID:38687637 | DOI:10.1080/16078454.2024.2346965 (Source: Hematology)
Source: Hematology - April 30, 2024 Category: Hematology Authors: ZhongLi Hu YanLi Yang JiaJia Li ZhongTing Hu Source Type: research