Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke.
CONCLUSIONS: The available trial evidence showed that, for individuals with acute ischaemic stroke, GP IIb-IIIa inhibitors are associated with a significant risk of intracranial haemorrhage with no evidence of any reduction in death or disability in survivors. These data do not support their routine use in clinical practice. The conclusion is driven by trials of Abciximab, which contributed 89% of the total number of study participants considered.
PMID: 24609741 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 8, 2014 Category: Journals (General) Authors: Ciccone A, Motto C, Abraha I, Cozzolino F, Santilli I Tags: Cochrane Database Syst Rev Source Type: research
In vitro effects of the glycoprotein IIb/IIIa receptor antagonists abciximab and eptifibatide on platelet aggregation in healthy cats.
Conclusions and Clinical Relevance-Eptifibatide caused a significant reduction in platelet aggregation in vitro, but there was no identifiable antiplatelet effect for abciximab. Eptifibatide and abciximab have different binding and inhibitory actions; therefore, it can be hypothesized that abciximab would be ineffective in cats because of a lack of receptor binding, reduced binding kinetics, or lack of downstream signaling. Eptifibatide may be useful in identifying hyperreactive platelets in cats in an in vitro platelet inhibitory assay.
PMID: 24564318 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - March 1, 2014 Category: Veterinary Research Authors: Magee AN, Hogan DF, Sederquist KA, Durham JA Tags: Am J Vet Res Source Type: research
Stent thrombosis with an aneurysm 7 years after a drug eluting stent implantation.
We report a case of very late stent thrombosis 7 years post sirolimus eluting stent implantation presenting as ST elevation MI while on dual antiplatelet therapy. Angiography revealed an aneurysm at the proximal end of the stent. The patient was managed successfully by primary percutaneous coronary intervention (PCI) with adjunct thrombus aspiration and intracoronary abciximab administration followed by deploying a mesh-covered stent MGuard. This very late complication is a rare presentation after a drug illuting stent (DES).
PMID: 24814120 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2014 Category: Cardiology Authors: Patil P, Sethi A, Kaul U Tags: Indian Heart J Source Type: research
Eptifibatide-induced acute profound thrombocytopenia: a case report
Conclusion:
This report adds another case of eptifibatide-induced thrombocytopenia to the medical literature and endorses the importance of platelet count monitoring after initiating therapy with this agent. (Source: BMC Research Notes)
Source: BMC Research Notes - February 25, 2014 Category: Research Authors: Christos GraidisChristos GoliasDimokritos DimitriadisGeorgios DimitriadisTheodosis BitsisIlias DimitrelosAfroditi TsiakouKonstantinos Charalabopoulos Source Type: research
Off-target effects of glycoprotein IIb/IIIa receptor inhibitors.
Abstract
Soon after identification of the platelet membrane glycoprotein (GP) IIb/IIIa receptor and due to its key role in platelet aggregation, it became the target of antithrombotic therapy. There are three intravenous glycoprotein IIb/IIIa receptor inhibitors (GPI) used in clinical practice, particularly in patients with acute coronary syndrome undergoing percutaneous coronary intervention. The aim of the current review is to summarize available knowledge concerning off-target effects of GPI. All three drugs have similar antithrombotic properties, but differ with respect to pharmocodynamics, pharmacokin...
Source: Cardiology Journal - February 14, 2014 Category: Cardiology Authors: Ostrowska M, Adamski P, Koziński M, Navarese EP, Fabiszak T, Grześk G, Paciorek P, Kubica J Tags: Cardiol J Source Type: research
Outcomes in Patients With ST-Segment Elevation Acute Myocardial Infarction Treated With Clopidogrel Versus Prasugrel (from the INFUSE-AMI Trial)
Prasugrel is more potent than clopidogrel, but it is not known whether this translates into clinical benefit in patients undergoing primary percutaneous coronary intervention (PCI) with bivalirudin for ST elevation myocardial infarction. In the Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction trial, 452 patients with anterior STEMI undergoing primary PCI with bivalirudin were randomized to intralesional abciximab or placebo and to thrombus aspiration or no aspiration. Clopidogrel or prasugrel were administered at physician discretion. The primary end point was infarc...
Source: The American Journal of Cardiology - February 13, 2014 Category: Cardiology Authors: Sorin J. Brener, Keith G. Oldroyd, Akiko Maehara, Magdi El-Omar, Bernhard Witzenbichler, Ke Xu, Roxana Mehran, C. Michael Gibson, Gregg W. Stone Tags: Coronary Artery Disease Source Type: research
Treatment of Radial Artery Occlusions Using Balloon Angioplasty and Localized Intra‐Arterial Abciximab
ConclusionsBalloon angioplasty and intrathrombus administration of abciximab via a catheter appears to be a safe, effective, and durable technique for reestablishing the patency of an occluded radial artery following transradial catheterization. Larger studies are needed to confirm our findings and establish the role for this technique in an algorithm for treatment of RAO. (Source: Journal of Interventional Cardiology)
Source: Journal of Interventional Cardiology - February 11, 2014 Category: Cardiology Authors: ZIAD JARADAT, BABAR BASIR, GEORGE REVTYAK Tags: Original Investigation Source Type: research
[Rescue treatment in acute thrombosis of intracranial stents].
CONCLUSION. The administration of abciximab as a rescue treatment seems safe in cases involving the formation of acute intrastent thromboses.
PMID: 24469937 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 1, 2014 Category: Neurology Authors: Pumar JM, Banguero A, Arias-Rivas S, Blanco M, Rodriguez-Yanez M, Sucasas P, Blanco M, Castineira-Mourenza JA, Vazquez-Herrero F Tags: Rev Neurol Source Type: research
The effectiveness of different functional fibrinogen polymerization assays in eliminating platelet contribution to clot strength in thromboelastometry.
CONCLUSIONS: FFPAs based solely on glycoprotein-IIb/IIIa inhibition, such as FFTEG or EXTEM-ABC, are less effective than cytochalasin D-based assays, such as FIBTEM or FIBTEM-S, at inhibiting the platelet component of clot strength. The FIBTEM PLUS assay, and the combination of FIBTEM and abciximab, sufficiently inhibits platelet contribution to clot elasticity. The combination of a glycoprotein-IIb/IIIa receptor blocker and cytochalasin D allows evaluation of functional fibrinogen polymerization without platelet "noise." In a clinical setting, the significance of potent platelet inhibition ensures a more accurate assessme...
Source: Anesthesia and Analgesia - January 24, 2014 Category: Anesthesiology Authors: Schlimp CJ, Solomon C, Ranucci M, Hochleitner G, Redl H, Schöchl H Tags: Anesth Analg Source Type: research
Aspiration of intact coronary bifurcation thrombus in ST-elevation myocardial infarction
We report a case of a 74-year-old female patient with acute chest pain who was admitted for primary percutaneous coronary angioplasty. The electrocardiogram indicated an acute ST-elevation myocardial infarction of the anterolateral wall. Coronary angiography showed a thrombus-containing lesion in the left anterior descending coronary artery with absence of a major diagonal branch (A; arrowhead). Administration of abciximab was not considered as there was some leakage of blood from the punctured, calcified femoral artery. An aspiration catheter was slowly advanced into the lesion, before vacuum-suction was initiated to manu...
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Clemens von Birgelen, Kenneth Tandjung, Ming Kai Lam Tags: Online Letters to the Editor Source Type: research
Systematic evaluation of evidence on veterinary viscoelastic testing Part 5: Nonstandard assays
ConclusionsNontraditional assays identified included thrombelastography (TEG)‐PlateletMapping (PM), functional fibrinogen assessment, and rapid‐TEG (r‐TEG). Direct veterinary evidence was found for only the ADP‐activated PM, which appears to generate valid data in dogs but not cats or horses. Arachidonic acid activated PM shows high variability and requires further assessment and validation in veterinary species. Functional fibrinogen assays may be performed in veterinary species but may require modification due to species differences in response to abciximab. While tissue factor (TF)‐activated TEG has been well ...
Source: Journal of Veterinary Emergency and Critical Care - January 10, 2014 Category: Veterinary Research Authors: Benjamin M. Brainard, Robert Goggs, Jose L. Mendez‐Angulo, Margaret C. Mudge, Alan G. Ralph, Bo Wiinberg Tags: Supplement Article Source Type: research
Intralesional Abciximab and Thrombus Aspiration in Patients With Large Anterior Myocardial Infarction: One-Year Results From the INFUSE-AMI Trial [ST-Segment-Elevation Myocardial Infarction]
Conclusions—
Intralesional abciximab and thrombus aspiration may have long-term benefits in patients with anterior ST-segment–elevation myocardial infarction presenting early after symptom onset and undergoing primary percutaneous coronary intervention with bivalirudin anticoagulation.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00976521. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - October 15, 2013 Category: Cardiology Authors: Stone, G. W., Witzenbichler, B., Godlewski, J., Dambrink, J.-H. E., Ochala, A., Chowdhary, S., El-Omar, M., Neunteufl, T., Metzger, D. C., Dizon, J. M., Wolff, S. D., Brener, S. J., Mehran, R., Maehara, A., Gibson, C. M. Tags: ST-Segment-Elevation Myocardial Infarction Source Type: research
Construction and characterization of a novel chimeric antibody c3C7 specific for the integrin αIIbβ3 complex.
In conclusion, after the modification, c3C7 retained the properties of its parent mAb with no loss of its biological activity. Therefore, c3C7 has the potential to become a novel agent for the treatment of thrombosis.
PMID: 24113827 [PubMed - as supplied by publisher] (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - October 11, 2013 Category: Microbiology Authors: Jiang A, Zhang W, Wu Q, Jin W, Tang Y, Zhang J, Liu JN Tags: Appl Microbiol Biotechnol Source Type: research
TEG and ROTEM: Technology and clinical applications
ABSTRACT
Initially described in 1948 by Hertert thromboelastography (TEG) provides a real‐time assessment of viscoelastic clot strength in whole blood. Rotational thromboelastometry (ROTEM) evolved from TEG technology and both devices generate output by transducing changes in the viscoelastic strength of a small sample of clotting blood (300 uL) to which a constant rotational force is applied. These point of care devices allow visual assessment of blood coagulation from clot formation, through propagation and stabilization, until clot dissolution. Computer analysis of the output allows sophisticated clot formation/dissol...
Source: American Journal of Hematology - October 3, 2013 Category: Hematology Authors: David Whiting, James A. DiNardo Tags: Test of the Month Source Type: research
Collagen Plug Vascular Closure Devices and Reduced Risk of Bleeding with Bivalirudin Versus Heparin Plus Abciximab in Patients Undergoing Percutaneous Coronary Intervention for Non ST‐Segment Elevation Myocardial Infarction
ConclusionsIn patients undergoing PCI for NSTEMI, the reduction of major bleeding by bivalirudin compared with UFH + abciximab was not affected whether a VCD was used. (Source: Journal of Interventional Cardiology)
Source: Journal of Interventional Cardiology - September 30, 2013 Category: Cardiology Authors: GREGOR LEIBUNDGUT, JÜRGEN PACHE, STEFANIE SCHULZ, PETER B. BERGER, MIROSLAW FERENC, MICHAEL GICK, JULINDA MEHILLI, ADNAN KASTRATI, FRANZ‐JOSEF NEUMANN Tags: Original Investigation Source Type: research
