Usefulness of the Left Anterior Descending Artery Wrapping Around the Left Ventricular Apex to Predict Adverse Clinical Outcomes in Patients with Anterior Wall ST-segment Elevation Myocardial Infarction (An INFUSE-AMI Substudy)
The relationship between left anterior descending artery (LAD) anatomical features and clinical outcomes in patients with anterior ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. The INFUSE-AMI trial randomized 452 patients with anterior STEMI undergoing mechanical revascularization to intralesional abciximab versus no abciximab and to manual thrombus aspiration versus no aspiration. The primary endpoint was infarct size (% left ventricle [LV] mass) by contrast magnetic resonance imaging (cMRI) at 30 days. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 20, 2015 Category: Cardiology Authors: Nobuaki Kobayashi, Akiko Maehara, Gary S. Mintz, Steven D. Wolff, Philippe Généreux, Ke Xu, Roxana Mehran, C. Michael Gibson, Sorin J. Brener, Gregg W. Stone Source Type: research
Pharmaceutical aspects of anti-inflammatory TNF-blocking drugs
Abstract
Tumor necrosis factor (TNF) is a key regulator of inflammatory processes in several immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriasis and psoriatic arthritis. Inactivating TNF has been found to be a plausible approach in treating these conditions. Two major strategies have been adopted by scientists to inactivate TNF: one is to use monoclonal antibodies (mAbs) that bind to TNF, and the other is to use fusion proteins that bind to TNF, both inactivate TNF and help to prevent TNF-mediated inflammatory process...
Source: Inflammopharmacology - February 17, 2015 Category: Drugs & Pharmacology Source Type: research
Spontaneous multi-vessel dissection associated with mid-menstrual cycle estrogen surge presenting as an acute myocardial infarction: A caution to be vigilant
Publication date: March 2015 Source:Journal of Indian College of Cardiology, Volume 5, Issue 1 Author(s): Pritesh Parekh , Navin Agrawal , Apurva Vasavada , Mahesh Vinchurkar , Mitesh Chauhan We are reporting the case of a middle aged female who presented with an acute anterior wall myocardial infarction on the thirteenth day of menstrual cycle (the timing of peak estrogen surge during a menstrual cycle of average duration). The patient was thrombolysed initially. Subsequent to the initial resolution of the symptoms immediately after lysis, the patient developed recurrence of symptoms and ECG showed the occurrence...
Source: Journal of Indian College of Cardiology - February 14, 2015 Category: Cardiology Source Type: research
Carotid stenting and intracranial thrombectomy for treatment of acute stroke due to tandem occlusions with aggressive antiplatelet therapy may be associated with a high incidence of intracranial hemorrhage
Conclusions
Primary stenting of the extracranial carotid artery combined with intracranial mechanical thrombectomy can be an effective treatment for tandem occlusions, can be performed with a high rate of technical success, and can achieve good clinical outcomes in selected patients. However, the incidence of SICH may be higher than in other patient populations and may be associated with the use of abciximab and advanced patient age. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - February 12, 2015 Category: Neurosurgery Authors: Heck, D. V., Brown, M. D. Tags: Ischemic stroke Source Type: research
Similar anti-inflammatory effects of intracoronary and intravenous Abciximab during primary percutaneous coronary intervention: a randomized study
Conclusions: Our study suggests that Abciximab has similar anti-inflammatory effects irrespective of the administration route. It is unlikely that the potential clinical benefits of intracoronary Abciximab can be related to modulation of integrin receptors. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - February 3, 2015 Category: Cardiology Tags: Percutaneous coronary interventions Source Type: research
Rescue Treatment of Thromboembolic Complications during Endovascular Treatment of Cerebral Aneurysms: A Meta-Analysis [FELLOWS' JOURNAL CLUB]
CONCLUSIONS:
Rescue therapy with thrombolytic agents resulted in significantly more morbidity than rescue therapy with glycoprotein IIb/IIIa inhibitors. Tirofiban/eptifibatide resulted in significantly higher recanalization rates compared with abciximab. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - January 13, 2015 Category: Radiology Authors: Brinjikji, W., Morales-Valero, S. F., Murad, M. H., Cloft, H. J., Kallmes, D. F. Tags: FELLOWS ' JOURNAL CLUB Source Type: research
Utility of Peak Creatine Kinase-MB Measurements in Predicting Myocardial Infarct Size, Left Ventricular Dysfunction and Outcome After First Anterior Wall Acute Myocardial Infarction (From the INFUSE-AMI Trial)
Infarct size after ST-segment elevation myocardial infarction (STEMI) is associated with long-term clinical outcomes. However, there is insufficient information correlating CK-MB or troponin levels to infarct size and infarct location in first–time occurrence STEMI. We, therefore, assessed the utility of CK-MB measurements after primary percutaneous coronary intervention (PCI) of a first anterior STEMI utilizing bivalirudin anticoagulation in patients who were randomized to intralesion abciximab vs. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 17, 2014 Category: Cardiology Authors: Tomotaka Dohi, Akiko Maehara, Sorin J. Brener, Philippe Généreux, Anthony H. Gershlick, Roxana Mehran, C. Michael Gibson, Gary S. Mintz, Gregg W. Stone Source Type: research
Prophylaxis of Experimental Endocarditis With Antiplatelet and Antithrombin Agents: A Role for Long-term Prevention of Infective Endocarditis in Humans?
Conclusions. Antiplatelet and direct antithrombin agents may be useful in the prophylaxis of IE in humans. In particular, the potential dual benefit of dabigatran etexilate might be reconsidered for patients with prosthetic valves, who require life-long anticoagulation and in whom S. aureus IE is associated with high mortality. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - December 12, 2014 Category: Infectious Diseases Authors: Veloso, T. R., Que, Y.-A., Chaouch, A., Giddey, M., Vouillamoz, J., Rousson, V., Moreillon, P., Entenza, J. M. Tags: BACTERIA Source Type: research
Sex, adverse cardiac events, and infarct size in anterior myocardial infarction: An analysis of Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction (INFUSE-AMI)
Conclusions In the INFUSE-AMI randomized trial, women with anterior STEMI experienced a higher rate of MACE, attributable to older age. Despite longer delay from symptom onset to reperfusion therapy, there was no difference between women and men in infarct size or reperfusion success. (Source: American Heart Journal)
Source: American Heart Journal - December 9, 2014 Category: Cardiology Source Type: research
The regional STEMI network registry: benefit of the introduction of the 24/7 primary PCI service.
CONCLUSIONS: The introduction of the 24/7 primary PCI regional service (the STEMI network) increased the accessibility of the invasive diagnosis and treatment, the frequency of the reperfusion therapy and improved the results of the treatment of patients suffering from acute ST-segment elevation myocardial infarction (STEMI). The patients with STEMI treated invasively had better outcome.
PMID: 25428812 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - November 27, 2014 Category: Cardiology Authors: Januś B, Rakowski T, Dziewierz A, Fijorek K, Sokołowski A, Dudek D Tags: Kardiol Pol Source Type: research
Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab.
Authors: Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C
Abstract
Tirofiban is a nonpeptide tyrosine derivative that together with eptifibatide (both small molecules) and abciximam belongs to the group of glycoprotein IIb/IIIa inhibitors. Though similar to abciximab in that it has a high affinity for the GP IIbIIIa inhibitor receptor, tirofiban dissociates from it much faster tan abciximab, what makes its action reversible in a few hours. Initially used upstream for treatment of patients with non ST-elevation acute coronary síndromes, recent evidence has shown its role as adjuntive therapy in pa...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Cardiovascular and Hematological Medicine in 2013 - Advances and Insights.
Authors: Mukherjee D
Abstract
Welcome to the first issue of Cardiovascular & Hematological Agents in Medicinal Chemistry (CHAMC) for 2013. I hope everyone has had an enjoyable holiday season and I want to wish everyone a wonderful New Year. As you know, our journal (CHAMC) aims to cover the latest and outstanding developments in medicinal chemistry, rational drug design for the discovery of novel cardiovascular and hematological Agents and discusses such therapies in clinical practice. Each issue contains a series of timely in-depth reviews, original research articles and drug clinical trial st...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Intracoronary injection of glycoprotein IIb/IIIa, abciximab, as adjuvant therapy in primary coronary intervention.
Authors: Rognoni A, Lupi A, Cavallino C, Rosso R, Veia A, Bacchini S, Bongo AS
Abstract
Acute coronary syndromes and, in paticular, ST - segment elevation myocardial infarction are the principle causes or mortality and morbidity in the industrialized countries. The manadgement of acute myocadial infarction is much debated in the literature; primary percutaneous coronary intervention is the treatment of choice. In the recent years there has been an increasing interest in the concept of adjunctive pharmacological therapy to improve outcomes in primary percutaneous coronary intervention. In the literature ran...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
A microchip flow-chamber system for quantitative assessment of the platelet thrombus formation process
Publication date: March 2012 Source:Microvascular Research, Volume 83, Issue 2 Author(s): Kazuya Hosokawa , Tomoko Ohnishi , Masashi Fukasawa , Taro Kondo , Hisayo Sameshima , Takehiko Koide , Kenichi A. Tanaka , Ikuro Maruyama As the pathogenesis of arterial thrombosis often includes platelet thrombus formation (PTF), antiplatelet agents are commonly used for the prevention of thromboembolic events. Here, using a novel microchip flow-chamber system we developed to quantitatively analyze the PTF process, we evaluated the pharmacological efficacies of antiplatelet agents under different arterial shear rates. Hir...
Source: Microvascular Research - November 10, 2014 Category: Biochemistry Source Type: research
Abciximab‐induced alveolar hemorrhage treated with rescue extracorporeal membranous oxygenation
We describe a case of a 75 year‐old woman presenting emergently with an anterior S‐T elevation myocardial infarction that deteriorated into ventricular fibrillation requiring prompt resuscitation, resulting in cardiogenic shock. Emergency primary percutaneous coronary intervention of the left anterior descending coronary artery with adjunctive abciximab and heparin resulted in adequate coronary flow, and intraaortic balloon pump was used to support hemodynamics. Within 12 hours of intervention, she developed acute respiratory distress with four‐quadrant opacification of lung fields, difficulty with oxygenation, and h...
Source: Catheterization and Cardiovascular Interventions - November 8, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Andrew W. Choi, John E. A. Blair, James D. Flaherty Tags: Case Report Source Type: research
