Leu33Pro (PlA) polymorphism of integrin beta3 modulates platelet Src pY418 and focal adhesion kinase pY397 phosphorylation in response to abnormally high shear stress
Conclusion
Taken together, our data indicates an important role of αIIbβ3 and shows that Leu33Pro polymorphism modulates the integrin-mediated Src and FAK signaling in platelets in response to shear stress. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 17, 2018 Category: Hematology Tags: Original Articles Source Type: research
Flow-diverter Stents for Internal Carotid Artery Reconstruction Following Spontaneous Dissection: A Technical Report
ConclusionReconstruction of the ICA as a rescue strategy for extracranial carotid dissection using flow-diverter stents is feasible and was performed without adverse events in this small series. (Source: Clinical Neuroradiology)
Source: Clinical Neuroradiology - August 13, 2018 Category: Neurology Source Type: research
Comparison of different microscopy approaches to quantification of inhibitory effect on thrombus formation under flow conditions by the example of adenosine receptor agonist HE-NECA
DiscussionWe conclude that wide-field imaging provides reliable qualitative data on an inhibitory effect on thrombus formation, despite differences which can emerge from various approaches to image analysis. However, quantitative evaluation and comparison of the efficacy of inhibitors on the basis of total area occupied by thrombi obtained by wide-field microscopy should be made with caution. To obtain a reliable, quantitative assessment of the effect of a tested compound on thrombus structure the use of confocal microscopy is inevitable. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 20, 2018 Category: Drugs & Pharmacology Source Type: research
What are the effects of the guidelines-recommended treatments of myocardial infarction on the secretion of pro- and anti-inflammatory cytokins in an in vitro murin inflammatory model?
ConclusionAspirin, abciximab and unfractionned heparin have an important anti-IL-1β effect, reducing its secretion. This could explain the lack of efficacy of the specific anti-IL-1β treatments during the acute phase of myocardial infarction. These results should be confirmed using an in vivo murin model and a human in vitro model. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 10, 2018 Category: Cardiology Source Type: research
Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution
Publication date: July 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 1Author(s): Andreas Koster, Michiel Morshuis, Ingvild Birschmann (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 10, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
What are the effects of the guidelines-recommended treatments of myocardial infarction on the secretion of pro- and anti-inflammatory cytokins in an in vitro murin inflammatory model?
ConclusionAspirin, abciximab and unfractionned heparin have an important anti-IL-1β effect, reducing its secretion. This could explain the lack of efficacy of the specific anti-IL-1β treatments during the acute phase of myocardial infarction. These results should be confirmed using an in vivo murin model and a human in vitro model. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 5, 2018 Category: Cardiology Source Type: research
Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution
Publication date: July 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 1Author(s): Andreas Koster, Michiel Morshuis, Ingvild Birschmann (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 5, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Active Reperfusion Hemorrhage during Thrombectomy: Angiographic Findings and Real-Time Correlation with the CT “Spot Sign”
Conclusions: Active reperfusion hemorrhage involving perforator arteries was observed to correlate with the CT “spot sign” and to be associated with poor outcomes.Intervent Neurol 2018;7:370 –377 (Source: Interventional Neurology)
Source: Interventional Neurology - June 8, 2018 Category: Neurology Source Type: research
Risk Scoring System to Assess Outcomes in Patients Treated with Contemporary Guideline-Adherent Optimal Therapies after Acute Myocardial Infarction.
CONCLUSIONS: The KorMI system would be a useful tool for predicting outcomes in survivors treated with guideline-adherent optimal therapies after AMI.
PMID: 29856143 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - June 3, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research
Pipeline Embolization for Salvage Treatment of Previously Stented Residual and Recurrent Cerebral Aneurysms
Conclusions: Salvage flow diversion for previously stented aneurysms is technically challenging but offers good prospects of aneurysm obliteration with acceptable complication rates.Intervent Neurol 2018;7:359 –369 (Source: Interventional Neurology)
Source: Interventional Neurology - June 1, 2018 Category: Neurology Source Type: research
Tirofiban Positively Regulates β1 Integrin and Favours Endothelial Cell Growth on Polylactic Acid Biopolymer Vascular Scaffold (BVS)
AbstractAn unexpectedly high incidence of thrombosis in patients that received the polylactic acid bioresorbable vascular scaffold (BVS) suggests a delayed/incomplete endothelial repair with this stent. The anti-platelet agent tirofiban stimulates endothelial cell migration and proliferation, mediated by VEGF production. We investigated the tirofiban effect on the migration and adhesion of endothelial cells to BVS, in vitro. We performed human umbilical endothelial cell (HUVEC) cultures in the presence of BVS. Tirofiban, similarly to VEGF, increased the ability of HUVEC to grow on the vascular scaffold, compared to unstimu...
Source: Journal of Cardiovascular Translational Research - April 25, 2018 Category: Cardiology Source Type: research
A comparison of intracoronary treatment strategies for thrombus burden removal during primary percutaneous coronary intervention: a COCTAIL II substudy
Conclusion
Either local drug delivery of abciximab or manual thrombus aspiration showed comparable results in terms of prestenting and poststenting thrombus burden removal. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 10, 2018 Category: Cardiology Tags: Original Research Source Type: research
A Randomized Double-Blind Placebo-Controlled Study Comparing Intracoronary Versus Intravenous Abciximab in Patients With ST-Elevation Myocardial Infarction Undergoing Transradial Rescue Percutaneous Coronary Intervention After Failed Thrombolysis
The risk and benefit ratio of glycoprotein IIb/IIIa inhibitors with dual oral antiplatelet therapy after failed thrombolysis and rescue percutaneous coronary intervention (PCI) is unclear. Using a randomized placebo-controlled, double-blind design, we compared intravenous (IV) and intracoronary (IC) abciximab delivery in 74 patients referred for rescue transradial PCI. The primary angiographic end points were the final thrombolysis in myocardial infarction flow and myocardial blush grades. Secondary end points included acute and 6-month outcomes using angiographic parameters, platelet aggregation parameters, cardiac biomar...
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Olivier F. Bertrand, Éric Larose, Rodrigo Bagur, Frédéric Maes, Valérie Gaudreault, Bernard Noël, Gérald Barbeau, Jean-Pierre Déry, Charles Pirlet, Olivier Costerousse, Early Discharge After Transradial Stenting of Coronary Arteries in Acute Myocar Source Type: research
A Randomized Double-Blind Placebo-Controlled Study Comparing Intracoronary vs Intravenous Abciximab in Patients with ST-Elevation Myocardial Infarction Undergoing Transradial Rescue Percutaneous Coronary Intervention after Failed Thrombolysis
The risk/benefit ratio of glycoprotein IIb/IIIa inhibitors with dual oral antiplatelet therapy after failed thrombolysis and rescue percutaneous coronary intervention (PCI) is unclear. Using a randomized placebo-controlled, double-blind design, we compared intravenous (IV) and intracoronary (IC) abciximab delivery in 74 patients referred for rescue transradial PCI. The primary angiographic endpoints were the final Thrombolysis in Myocardial Infarction (TIMI) flow and myocardial blush grades. Secondary endpoints included acute and 6-month outcomes using angiographic parameters, platelet aggregation parameters, cardiac bioma...
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Olivier F. Bertrand, Éric Larose, Rodrigo Bagur, Frédéric Maes, Valérie Gaudreault, Bernard Noël, Gérald Barbeau, Jean-Pierre Déry, Charles Pirlet, Olivier Costerousse, EArly Discharge after Transradial Stenting of CoronarY Arteries in Acute Myocar Source Type: research
