A case of anomalous origin of left main coronary artery from the pulmonary artery combined with anomalous aortic origin of the right coronary artery from the left coronary sinus
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Images in CAD Source Type: research

Epicardial and microvascular coronary spasm in the same patient?—acetylcholine testing pointing towards a common pathophysiological background
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Images in CAD Source Type: research

Superdominant left anterior descending artery with posterolateral branch from circumflex
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Images in CAD Source Type: research

Radial versus femoral approach for rotational atherectomy
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Research Communications Source Type: research

Tanshinone IIA protects mice against atherosclerotic injury by activating the TGF-β/PI3K/Akt/eNOS pathway
Conclusion TIIA can lower levels of serum lipids, stabilize atherosclerotic plaques, reduce endothelial injury, and inflammatory damage by activation of the TGF-β/PI3K/Akt/eNOS pathway. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Translational Science Source Type: research

Lipoprotein(a) and long-term recurrent infarction after an episode of ST-segment elevation acute myocardial infarction
Conclusions After an episode of STEMI, only extreme high values of lipoprotein(a) were associated with an increased risk of long-term recurrent MI. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

Interaction of tobacco smoking and alcohol consumption with obesity on cardiovascular disease in a Chinese cohort
Conclusion We found significant interactions between alcohol drinking and abdominal obesity, smoking and abdominal obesity on CVD risk, suggested that the effect of alcohol drinking or smoking on CVD susceptibility seems to be modified by abdominal obesity. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

The impact of atherosclerotic risk factors on disease progression in patients with previously diagnosed nonobstructive coronary artery disease: factors affecting coronary artery disease progression
Conclusion Our results indicate that no single risk factor alone is related with development of obstructive CAD; however, patients with high number of multiple risk factors are more prone to develop obstructive disease and require closer follow-up. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

Unplanned hospital readmissions after acute myocardial infarction: a nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014
Conclusion Readmissions during the first month after AMI occur in more than one in 10 patients resulting in a healthcare cost of ~718 million USD per year and ~281000 additional bed days per year. These findings have important public health implications. Strategies to identify and reduce readmissions in AMI will dramatically reduce healthcare costs for society. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Myocardial Infarction Source Type: research

Effect on mortality of different routes of administration and loading dose of aspirin in patients with ST-segment elevation acute myocardial infarction treated with primary angioplasty
Background: Aspirin is the cornerstone of the anti-platelet therapy during the acute phase of ST-segment elevation myocardial infarction (STEMI), and it can be administrated orally or intravenously. The oral loading dose of aspirin is well characterized, whereas there are little data on the optimal intravenous (IV) loading dose. Aim: To confirm if the mortality of patients treated with a loading dose of IV aspirin was comparable to that of patients treated with the most usual aspirin per os. Patients and methods: We analyzed the overall mortality during hospitalization and at 1 year follow-up among 756 consecutive ...
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Myocardial Infarction Source Type: research

Clinical comparison study between a newly developed optical-based fractional flow reserve device and the conventional fractional flow reserve device
Background Fractional flow reserve (FFR) measurement is the gold standard for identifying the functional severity of coronary artery disease. Although we can use newly developed pressure wires with optical fibers are now available, their safety and accuracy for FFR measurement are not clear. Therefore, we planned a clinical comparison study between pressure wires with optical fibers and the conventional FFR device. Methods We prospectively enrolled 51 patients (51 lesions) with intermediate coronary artery stenosis. For these lesions, FFR measurements with pressure wires with optical fibers were compared with those ob...
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: Physiology Source Type: research

Long-term outcomes of percutaneous coronary intervention for unprotected left main coronary artery according to the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score
Conclusions Despite the high success rates of uLMCA PCI in real-world patients with high SYNTAX score, the latter was significantly associated with worse three-year outcomes. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: PCI Source Type: research

Trends and predictors of coronary revascularization in patients with coronary artery anomalies and acute myocardial infarction: a nationwide analysis of 8131 patients
Objective Acute myocardial infarction (AMI) is rarely associated with coronary artery anomalies (CAA). This confluence makes it difficult to identify and treat the culprit lesion with percutaneous coronary intervention (PCI). Our objective was to evaluate trends and predictors of revascularization in patients with CAA and AMI using a large national database. Methods We included adult patients with CAA presenting as ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) and undergoing coronary angiography from Nationwide Inpatient Sample from 2000 to 2011, using IC...
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: PCI Source Type: research

Multicenter experience with percutaneous coronary intervention for chronic total occlusion in Korean population: analysis of the Korean nationwide multicenter chronic total occlusion registry
Conclusions Twelve-month success rates, safety profiles, and cumulative clinical outcomes of Korean CTO patients were favorable post-PCI. Long-term follow-up of larger study populations is necessary to validate our findings. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - May 1, 2020 Category: Cardiology Tags: PCI Source Type: research

Coronary artery dissection due to severe coronary vasospasm during ergonovine provocation test
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Images in Coronary Artery Disease Source Type: research

Effect of semaglutide on coronary atherosclerosis progression in patients with type II diabetes: rationale and design of the semaglutide treatment on coronary progression trial
Conclusion: Our current study will provide important imaging-derived data that may add relevance to the clinically derived outcomes from liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results and semaglutide and cardiovascular outcomes in patients with type 2 diabetic mellitus 6 trials. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Clinical Trial Design Source Type: research

Vascular reactivity to mental stress is associated with poor cardiovascular disease outcomes in females following acute coronary syndrome
Background: We aimed to test the hypothesis that peripheral endothelial dysfunction induced by mental stress may predict cardiovascular events after acute coronary syndrome beyond traditional cardiovascular disease risk factors. Methods: This was a prospective study in which 417 patients who had acute coronary syndrome were enrolled in two sites at the US and Qatar. Cardiovascular disease risk factors such as past medical history, blood pressure, heart rate, peripheral endothelial dysfunction, and response to three different mental stress examinations (Stroop Color Word, Arithmetic, and Spiral Omnibus) as assessed by ...
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Endothelial Function Source Type: research

Characteristic findings of acute spontaneous coronary artery dissection by cardiac computed tomography
Conclusion: CCT was able to identify the presence of SCAD in most of the patients in the acute phase of this elusive and challenging clinical entity. In addition, in this setting, CCT revealed unique and distinct radiologic features and provided a precise assessment of lesion severity. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Coronary Artery Dissection Source Type: research

Automated external defibrillator use and outcomes after out-of-hospital cardiac arrest: an Israeli cohort study
Conclusion Deployment of AEDs in public places by mandatory regulations increased utilization for OHCA and may improve outcomes. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Cardiac Arrest Source Type: research

Efficacy of nicorandil on the prevention of contrast-induced nephropathy in patients with coronary heart disease undergoing percutaneous coronary intervention
This study randomized 300 patients undergoing percutaneous coronary intervention to receive conventional treatment in the control group (hydration only; n = 150) vs. nicorandil therapy (nicorandil 10 mg three times daily plus hydration; n = 150). The primary endpoint was the incidence of contrast-induced nephropathy, defined as rise in serum creatinine ≥44.2 μmol/L or>25% above baseline within 72 hours after exposure to contrast administered during percutaneous coronary intervention. Secondary endpoints included differences in post-percutaneous coronary intervention serum creatinine, blood urea nitrogen, creatinin...
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Contrast Nephropathy Source Type: research

Inflammatory markers of contrast-induced nephropathy in patients with acute coronary syndrome
This study included 232 consecutive patients with acute coronary syndrome who underwent emergency angiography at our center. Results: There were 38 (19.1%) patients in the CIN group (mean age: 62.4 ± 10.2; 68.4% male), and 162 patients in the non-CIN group (mean age: 62.1 ± 11.5; 60.5% male). In the CIN positive group, serum gamma-glutamyl transferase (GGT) (P (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Contrast Nephropathy Source Type: research

Clinical benefits of prolonged dual antiplatelet therapy following complex percutaneous coronary intervention
Conclusion Prolonged DAPT reduces cardiac mortality and major adverse cardiovascular events in complex PCI. The results would need confirmation in a larger randomized study. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Anti-platelet therapy Source Type: research

Interaction of CYP2C19 G681A polymorphism and omeprazole on clopidogrel responsiveness and impact in patients with acute coronary syndrome
Conclusion In ACS patients, the effect of the CYP2C19 G681A polymorphism on clopidogrel responsiveness, but not omeprazole use, is strong. However, a combination of both factors enhances clopidogrel hyporesponsiveness. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Anti-platelet therapy Source Type: research

Antithrombotic regimen for patients with cardiac indication for dual antiplatelet therapy and anticoagulation: a meta-analysis of randomized trials
Conclusion Dual antithrombotic and NOAC regimens have reduced bleeding without compromising the risk of cardiovascular events or mortality, and should be preferred for patients with ACS or PCI also needing long-term anticoagulation. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: Anti-platelet therapy Source Type: research

Effect of intracoronary tirofiban following aspiration thrombectomy on infarct size, in patients with large anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Conclusion In patients early presented with large anterior STEMI, infarct size at 30 days was significantly decreased by intracoronary tirofiban delivered to the infarct lesion site followed aspiration thrombectomy. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: STEMI Source Type: research

Association of lymphocyte-to-monocyte ratio with the long-term outcome after hospital discharge in patients with ST-elevation myocardial infarction: a retrospective cohort study
Objective Lymphocyte-to-monocyte ratio (LMR), a novel systemic inflammatory factor, correlates with adverse outcomes in patients with cardiovascular disease. However, data are limited regarding the prognostic value of LMR in patients with ST-elevation myocardial infarction (STEMI) after hospital discharge. Therefore, the aim of our study was to evaluate the prognostic impact of admission LMR in hospital survivors of STEMI. Methods This retrospective observational study enrolled 1369 STEMI patients between 2014 and 2017. The study population was divided into three groups according to tertiles (T) of LMR (T1: ≥2.84; ...
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: STEMI Source Type: research

CHA2DS2-Vasc score and saphenous vein graft disease in patients with coronary artery bypass graft surgery
In this study, we aimed to investigate the association between CHA2DS2-VASc score and saphenous vein graft disease (SVGD) in patients with history of CABG surgery. Methods A total of 241 patients who had undergone CABG surgery and who underwent coronary angiography due to stable angina pectoris symptoms were reviewed retrospectively. SVGD was defined as ≥50% stenosis in at least one SVG. Patients were divided into two groups according to the presence or absence of SVGD. Results It was found that CHA2DS2-VASc scores were significantly higher in SVGD group. In multivariate logistic regression analysis, time interval...
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: CABG Source Type: research

Six months follow-up of protected high-risk percutaneous coronary intervention with the microaxial Impella pump: results from the German Impella registry
Conclusions: Patients undergoing protected high-risk percutaneous coronary intervention with Impella support showed an acceptable 180-day clinical outcome regarding major adverse cardiac event and mortality. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Weighing the potential late benefits versus early hazard associated with bioresorbable vascular scaffolds in percutaneous coronary interventions: a Markov decision analytic model
Conclusions Based on currently available data, it would take approximately 21.8 years for the presumed late benefits of current BRS relative to EES to overcome the early hazard associated with their use under favorable assumptions. Optimal implantation technique and limiting procedures to larger vessels improved BRS performance and reduced time to equipoise. Eliminating the higher BRS thrombosis risk is necessary in developing future generations of BRS as an acceptable alternative to EES. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Anatomical features and clinical outcome of a honeycomb-like structure in the coronary artery: reports from 16 consecutive patients
Conclusions: Despite the presence of recanalization, most honeycomb-like structure lesion have a positive fractional flow reserve. Further study is required to address how to protect a large side branch taking from honeycomb-like structure. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Long-term clinical outcomes in patients with unstable angina undergoing percutaneous coronary interventions in a contemporary registry data from Poland
Conclusion Three-year prognosis in unstable angina was considerable better in comparison with NSTEMI. On the contrary, after adjustment for baseline differences, the outcomes (death, MI, MACE) in unstable angina and stable angina patients were comparable. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Impact of periprocedural myocardial injury on long-term clinical outcomes of chronic total occlusion patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis
Background: Several studies have evaluated the long-term clinical outcomes of periprocedural myocardial injury for chronic total occlusions patients. However, the results of these studies were inconsistent. To determine whether the periprocedural myocardial injury has adverse effects on long-term clinical outcomes in chronic total occlusion patients undergoing percutaneous coronary intervention. Methods: We searched Cochrane Library, PubMed, and Embase for eligible articles from their date of inception up to March 2019. Long-term clinical outcomes included major adverse cardiac events, all-cause death, cardiac death, ...
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

The effect of pre-procedural sublingual nifedipine on radial artery diameter
Conclusions Sublingual nifedipine administration before RA puncture has an obvious dilatation effect on small diameter RAs. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Drug-eluting balloons versus drug-eluting stents for small vessel coronary artery disease: a meta-analysis
Conclusion In summary, this study demonstrates that treatment of small vessel (diameter ≤ 3 mm) coronary artery disease (CAD) with DEB may lead to improving outcomes compared with the use of DES within a follow-up period of 9–24 months. Further large clinical trials are needed to verify this conclusion. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 9, 2020 Category: Cardiology Tags: PCI Source Type: research

Necessity of back-up pace maker support during acetylcholine testing as a safe method
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Coronary Spasm Source Type: research

Early versus delayed treatment with ticagrelor on residual thrombus after percutaneous coronary intervention in patients presenting with non-ST-elevation acute coronary syndrome: an optical coherence tomography study
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: NSTEMI Source Type: research

Coronary artery aneurysm in Kawasaki disease: from multimodality imaging
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Images in CAD Source Type: research

Coronary artery tortuosity: a narrative review
Coronary artery tortuosity (CAT) is a prevalent angiographic finding commonly associated with aging, hypertension, atherosclerosis and other conditions. Preliminary evidence suggests that degradation of elastin, a key component of extracellular matrix in the vascular wall, may be responsible for the development of CAT. The clinical significance of CAT should be considered in several aspects. First, coronary flow alteration associated with CAT may result in myocardial ischemia owing to reduced perfusion pressure distal to the tortuous segment. Second, increased and oscillatory shear stress in the tortuous vessel may promote...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Reviews in Depth Source Type: research

Impact of sex and race on underuse of cardiovascular stress testing in the outpatient setting
No abstract available (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Disparities in CAD Care Source Type: research

Long-term outcomes after percutaneous coronary intervention relative to bypass surgery in diabetic patients with multivessel coronary artery disease according to clinical presentation
Conclusion Among diabetic patients with MVD, the long-term outcomes of PCI versus CABG differed according to clinical presentation. CABG may be more beneficial for NSTE-ACS patients with MVD in reducing MACCE and MI, whereas PCI was as effective as CABG for SCAD patients with MVD. Therefore, clinical presentation must be considered when choosing revascularization strategies in these patients. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: CAD in Diabetics Source Type: research

Silent coronary artery disease in asymptomatic patients with severe aortic stenosis and normal exercise testing
Conclusion: Our results are the first to show that in patients with severe aortic stenosis, normal left ventricular ejection fraction,, and normal exercise testing, significant coronary artery disease is present in as many as 1/5 patients. In such patients, further prospective studies are warranted to address the diagnostic value of brain natriuretic peptide in detecting silent coronary artery disease. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Coronary Disease in Aortic Stenosis Source Type: research

Predictive value of the combination of brachial-ankle pulse wave velocity and ankle-brachial index for cardiovascular outcomes in patients with acute myocardial infarction
Conclusion: Our findings indicate that ankle-brachial index is a strong independent prognostic factor and adding a brachial-ankle pulse wave velocity measurement to ankle-brachial index increases the prognostic power for cardiac events in patients with acute myocardial infarction, while ankle-brachial index and pulse wave velocity showed additive value to risk factors. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

Homocysteine is an independent predictor of long-term cardiac mortality in patients with stable coronary artery disease in the era of statins
Background Homocysteine (Hcy) is considered a risk factor for cardiovascular disease. Objective To explore the long-term prognostic value of Hcy in patients with stable coronary artery disease (CAD) in the era of statins. Methods A total of 876 consecutive patients with stable CAD were recruited and followed up for a median of 6.1 years. Lipids and Hcy levels were measured at baseline. Primary endpoints were cardiac death and secondary endpoints were hospitalizations for acute coronary syndrome, myocardial revascularization, arrhythmic event or ischemic stroke. Results Follow-up data were obtained from 84...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

Hyponatremia is associated with poor prognosis among patients with chest pain discharged from internal medicine wards following acute coronary syndrome-rule-out
Background Hyponatremia is the most common electrolyte abnormality observed in clinical practice. Among patients with acute coronary syndrome (ACS), serum sodium levels are inversely associated with mortality risk. We assessed associations of serum sodium level with ACS and mortality in patients with chest pain. Methods This retrospective cohort study used clinical data from a large, academic hospital. All adults admitted with chest pain and without hypernatremia and discharged after ACS rule-out from January 2010 through June 2016 were included. The primary endpoint was the composite of 30-day ACS and mortality. Seco...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: Risk Factors Source Type: research

Impact of periprocedural biomarker elevation on mortality in stable angina pectoris patients undergoing elective coronary intervention: a systematic review and meta-analysis including 24 666 patients
Background Uncertainty remains regarding the exact prognostic impact of biomarker elevation following percutaneous coronary intervention in patients with stable angina pectoris and the subsequent risk of death. We sought, therefore, to evaluate the effect of periprocedural myocardial infarction on the subsequent mortality risk following percutaneous coronary intervention in patients with stable angina pectoris and normal preprocedural cardiac biomarkers level. Methods After a systematic literature search was done in PubMed and EMBASE, we performed a meta-analysis of studies with post-procedural cardiac biomarkers data...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: PCI Source Type: research

Relationship between C-reactive protein-to-albumin ratio and the extent of coronary artery disease in patients with non-ST-elevated myocardial infarction
This study aimed to investigate the predictive value of the newly defined C-reactive protein (CRP)-toalbumin ratio (CAR) in determining the extent and severity of coronary artery disease (CAD) in comparison with the other inflammatory markers such as neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), in patients with non-ST-elevated myocardial infarction (NSTEMI). Patients and methods This study is retrospectively designed and includes 205 patients with NSTEMI with a mean age of 56.6± 11.4 years. The study cohort was subdivided into two groups according to Synergy Between Percutaneous Cor...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: NSTEMI Source Type: research

Comparison of prognostic significance between serum fibrinogen and Global Registry of Acute Coronary Events score for prognosis of patients with non-ST-elevation acute coronary syndromes undergoing percutaneous coronary intervention
Conclusion Fibrinogen is an independent predictor of death/nonfatal reinfarction in patients with NSTE-ACS undergoing PCI, and its accuracy is similar to that of the GRACE system. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: NSTEMI Source Type: research

Elevated neutrophil gelatinase-associated lipocalin levels before contrast media administration among ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention
Background Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein released by renal tubular cells upon nephrotoxic or ischemic events and is considered an early marker of tubular damage. We aimed to demonstrate the presence of early renal injury detected by elevated NGAL levels taken before contrast administration in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). Patients and methods We prospectively included 88 patients with STEMI treated with PCI. Blood samples for plasma NGAL were drawn immediately before PCI (baseline NGAL; NGAL...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: STEMI Source Type: research

Predictive value of the combination of age, creatinine, and ejection fraction score and diabetes in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be improved by establishing novel ACEF-derived risk models. Methods: A total of 1146 patients were included. The study endpoint was 1-year major adverse cardio-cerebrovascular events, including all-cause death, nonfatal myocardial infarction, unplanned revascularization, and nonfatal stroke. Accuracy was defined w...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: STEMI Source Type: research

Incidence, characteristics and outcomes in very young patients with ST segment elevation myocardial infarction
Objective ST-segment elevation acute myocardial infarction (STEMI) in very young adults is uncommon. Many studies have focused on the cutoff of 45–50 years old to define young patients with STEMI leaving limited data on the group of very young patients aged less than 35 years old. We investigated the incidence of STEMI in different subgroups of young patients and focused on the characteristics, possible pathogenesis and outcomes in very young patients aged less than 35 years old. Methods We retrospectively studied 792 STEMI patients aged less than 55 years who underwent successful pri...
Source: Coronary Artery Disease - January 31, 2020 Category: Cardiology Tags: STEMI Source Type: research