The impact of atorvastatin on dabigatran plasma levels in patients with atrial fibrillation
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: LETTERS TO THE EDITOR Source Type: research

Evaluating the potential benefits of the extravascular pool of factor IX
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: LETTERS TO THE EDITOR Source Type: research

Thromboelastometry-guided neuraxial anesthesia in a parturient with severe thrombocytopenia due to large granular lymphocytic leukemia
Severe thrombocytopenia (platelet count (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: CASE REPORT Source Type: research

Type II antithrombin deficiency caused by a novel missense mutation (p.Leu417Gln) in a Chinese family
The aim of the report was t o explore the phenotype and genotype of a hereditary antithrombin deficient Chinese family. Functional and molecular analysis of the proband and his family members was performed. Online bioinformatics software was used to predict the pathogenicity of the novel mutation. ClustalX-2.1-win and PyMol software were applied to conservative analysis and generate molecular graphic images, respectively. Functional analysis had shown that the antithrombin (AT):A of the proband was reduced to 32% whereas AT:Ag was normal. Molecular analysis revealed a heterozygous missense mutation p. Leu417Gln in exon...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: MUTATION REPORT Source Type: research

Microkinetic coagulation assays for human and zebrafish plasma
In conclusion, we established a microkinetic assay that could measure blood coagulation activity in models like zebrafish and human blood samples obtained from a finger prick in adults or heel prick in infants. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: TECHNICAL REPORT Source Type: research

Coronavirus disease 2019 and coagulopathy: other prothrombotic coagulation factors
There is an increasing evidence supporting the existence of coagulopathy in coronavirus disease 2019 (COVID-19) patients. Most of reports are mainly focused on d-dimer. Our objective is to describe coagulation parameters in these patients that could be involved in a hypercoagulate state and to test platelet function to see if there are short closure times. We analyzed coagulation samples from 80 patients admitted with COVID-19 in our hospital. We also tested platelet function by closure times in a small subgroup of patients. Most of samples had increased d-dimer (96.2%) (median of d-dimer: 1158 ng/ml FEU), increased fi...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

The incidence of venous thromboembolic events in trauma patients after tranexamic acid administration: an EAST multicenter study
To determine if there is a significant association between administration of tranexamic acid (TXA) in severely bleeding, injured patients, and venous thromboembolism (VTE), myocardial infarction (MI), or cerebrovascular accident (CVA). A multicenter, retrospective study was performed. Inclusion criteria were: age 18–80 years old and need for 5 units or more of blood in the first 24 h after injury. Exclusion criteria included: death within 24 h, pregnancy, administration of TXA more than 3 h following injury, and routine ultrasound surveillance for deep venous thrombosis. Incidence of VTE was the primary outco...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Fibrin clot susceptibility to lysis is impaired after on-pump coronary artery by-pass grafting with tranexamic acid: clinical implications
Coronary artery bypass grafting (CABG) done on-pump may cause a significant blood loss. Low fibrinogen is associated with perioperative bleeding. The influence of cardiopulmonary bypass on fibrin clot properties is poorly investigated. We studied 55 patients with isolated coronary artery disease on aspirin undergoing on-pump CABG with tranexamic acid. Fibrinogen levels, fibrinolytic capacity expressed as clot lysis time (CLT), thrombin generation potential and platelet count were assessed before and after the surgery (prior to admission to the intensive care unit). A postoperative drop in haemoglobin (−30% from basel...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Factors associated with deep venous thrombosis in patients infected with coronavirus disease 2019: a meta-analysis
Coronavirus disease 2019 (COVID-19) has affected more than 6 million patients worldwide. Deep venous thrombosis (DVT) has been increasingly recognized complication in these patients and is associated with increased morbidity and mortality. However, the factors associated with development of DVT in patients with COVID-19 have not been elucidated due to the novelty of the virus. We performed a meta-analysis of published studies comparing laboratory results in COVID-19 patients with and without DVT with the aim of identifying risk factors. We searched major databases for studies evaluating DVT in COVID-positive patients and p...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

A pilot randomized trial of atorvastatin as adjunct therapy in patients with acute venous thromboembolism
Venous thromboembolism (VTE) is the third most common cardiovascular disease and optimizing treatment is essential. In this single-center pilot study, we sought to investigate the effects of statins in addition to anticoagulation in patients with acute VTE. We enrolled patients over 18 with an acute proximal lower extremity deep vein thrombosis with or without pulmonary embolism. Patients were randomized to anticoagulation alone (with either warfarin or rivaroxaban) or anticoagulation and atorvastatin 40 mg daily and followed for 9 months. The primary objective was to determine if adjunct atorvastatin reduced thrombin ge...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Important decrease in invariant natural killer T, CD4+ regulatory T cells, CD8+ regulatory T cells, gamma–delta T cells, and CD4+ T lymphocytes in HIV-negative patients with hemophilia
Hereditary hemophilias are X-linked inherited bleeding disorders defined as deficiencies of the coagulation factors VIII or IX. They are characterized by easy to provoke or spontaneous bleeding. HIV infection in hemophilic patients is a risk factor for the reduction of CD4+ T cells. There is no information regarding the cellular immune function in HIV-negative patients with hemophilia. To evaluate the number of lymphocyte subsets in adult patients with hemophilia A or B as compared with healthy donors. 39 Adult hemophilics and 27 healthy donors were included. Lymphocyte subsets [CD4 and CD8 T cells, natural killer cells, n...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Preservation of thrombin generation in cirrhosis despite abnormal results of international normalized ratio: implications for invasive procedures
Thrombin generation is normal or elevated in patients with cirrhosis when tested in the presence of thrombomodulin, the activator of the main natural anticoagulant protein C. However, the relationship between thrombin generation with bleeding has been little explored in literature. 97 Consecutive patients with cirrhosis were prospectively included (58 men; 54 ± 10 years) and divided into two groups international normalized ratio (INR) less than 1.5 (n = 72) or INR at least 1.5 (n = 25). 46 Healthy individuals were tested as controls. Endogenous thrombin potential (ETP) was measured without and with the a...
Source: Blood Coagulation and Fibrinolysis - January 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography
Trauma with hemorrhagic shock causes massive tissue plasminogen activator release, plasmin generation, and hyperfibrinolysis. Tranexamic acid (TXA) has recently been used to treat bleeding in trauma by preventing plasmin generation to limit fibrinolysis. Trauma patients also have increased complement activation that correlates with mortality and organ failure, but the source of activation is not clear, and plasmin has recently been shown to efficiently cleave C3 and C5 to their activated fragments. We hypothesized that trauma patients in hemorrhagic shock with hyperfibrinolysis on thromboelastography (TEG) LY30 would have ...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: SHORT COMMUNICATION Source Type: research

Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children
We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. Given the hepatic tropism and COVID-19-related hyperinflammatory reactions, our case suggests that, an isolated severe hyperphosphatasemia in children with SARS-CoV-2 infection should increase the possibility of transient hyperphosphatasemia, even if is also demonstrated a classic natural history of the transient hyperphosphatasemia during viral infection, especially in SARS-CoV-2 infection. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: CASE REPORT Source Type: research

A novel heterozygous mutation (γIIe367Thr) causes congenital dysfibrinogenemia in a Chinese family
The aim of this study was to elucidate the molecular defects in a Chinese family with dysfibrinogenemia. The fibrinogen activity was measured by the one-stage clotting method. The fibrinogen antigen was measured with immunoturbidimetry. The fibrinogen gene was amplified by PCR with direct sequencing. Suspected mutation was confirmed by reverse sequencing. Bioinformatics and model analysis were used to study the conservatism and harm of the mutation. The proband had a history of menorrhagia. Study showed fibrinogen activity at 0.35 g/l and fibrinogen antigen at 2.05 g/l. Sequencing analysis detected a heterozygous c.117...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: MUTATION REPORT Source Type: research

Prospective evaluation of variables affecting platelet function in patients with newly diagnosed chronic myeloid leukemia
Platelet function in chronic myeloid leukemia (CML) could be affected by either hyperleucocytosis, clonal megakaryopoiesis, or tyrosine kinase inhibitors. However, these variables have never been prospectively evaluated. We conducted a prospective study over a period of 1.5 years in a tertiary care center of north India. Patients with CML in chronic phase, more than 18 years, and treated with imatinib were enrolled (n = 32). Age, and sex-matched controls were also included. Platelet function test was performed using two-channel Chrono-Log aggregometer 490 at four time-points: first, at diagnosis; second, after leucored...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

The association of oxygen saturation, tomography findings and d-dimer levels in coronavirus disease 2019 patients
This study included 94 patients, 48 women (51%) and 46 men (49%), diagnosed by PCR method. Patients without any suspicious findings on thorax tomography and having oxygen saturation above 90% at the time of presentation were included as the first group. Patients with suspicious tomography findings but having oxygen saturation above 90% were designed as the second group, and patients with both suspicious tomography findings for COVID-19 and low oxygen saturation levels ( (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Detection of hypofibrinogenemia during cardiac surgery: a comparison of resonance-based thrombelastography with the traditional Clauss method
Bleeding after cardiac surgery is associated with significant morbidity and mortality. Hypofibrinogenemia is a crucial factor for bleeding in this setting and may be rapidly detected using point-of-care viscoelastic tests (POC-VET). However, the correlation of POC-VET with conventional coagulation assays is still unclear. The current study aimed to correlate resonance-based POC-VET assays (Haemonetics TEG 6s) with the traditional nonrapid Clauss method. Another aim was to identify a cut-off value for the detection of hypofibrinogenemia (fibrinogen plasma level below 150 mg/dl) focusing on the maximum amplitude of the TEG...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Reduced IL-35 in patients with immune thrombocytopenia
The occurrence and development of primary immune thrombocytopenia is closely related to autoimmune imbalanced. Thus, we conducted the current study to investigate the modulation of IL-35, a newly identified immunological self-tolerance factor on immune thrombocytopenic purpura (ITP). We were enrolled peripheral blood in 21 adult healthy volunteers, 21 active primary ITP patients and 16 ITP patients in remission. In the same period, bone marrow plasma was drawn from active primary ITP patients and 16 bone marrow donors. Enzyme-linked immunoassay was used to measure IL-35 levels in bone marrow mononuclear cells and periphera...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Clinical safety and efficacy of thrombolytic therapy with low-dose prolonged infusion of tissue type plasminogen activator in patients with intermediate-high risk pulmonary embolism
This study enrolled 16 retrospectively evaluated patients (female 9, mean age: 70.9 ± 13.5 years) with the diagnosis of acute pulmonary embolism who were treated with low-dose and slow-infusion of tissue-type plasminogen activator (t-PA). All patients underwent transthoracic echocardiography and computed tomography scan for assessment of thrombolytic therapy success. Low-dose prolonged thrombolytic therapy was successful in all patients. The mean t-PA dose used was 48.4 ± 6.3 mg. There was residual segmental thrombus in nine (56.3%) patients after thrombolytic therapy. The arterial oxygen saturation...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Discrepancy between the results of one-stage and chromogenic factor VIII:C assays in patients with mild/moderate hemophilia A
Diagnosis of hemophilia A is generally based on the measurement of plasma factor VIII activity (FVIII:C) using the one-stage assay (OSA) or the two-stage chromogenic substrate assay (CSA). The results of these methods show considerable discrepancy in about one-third of non-severe hemophilia A patients. The aim of this study was to assess the prevalence of FVIII:C assay discrepancy in non-severe hemophilia A patients in Iran and the relationship between the bleeding tendency with the level of FVIII:C by each method. Patients registered as mild or moderate hemophilia A in hemophilia clinic of Imam Khomeini Hospital were incl...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

High prevalence of overweight/obesity in adult persons with hemophilia in Utah and a review of the literature
The objectives of this study were firstly to determine the prevalence of overweight/obesity in adult persons with hemophilia in Utah, and to explore the association between age, disease severity and race with body mass index (BMI), and secondly to provide recent data on the prevalence of overweight/obesity in the hemophilia population via a review of the literature. We conducted a retrospective cross section study of adult persons with hemophilia who were seen at a Utah hemophilia treatment center from 1 January 2017 to 31 December 2019. The electronic database PubMed was searched for studies with observation periods from ...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Severe thrombocytopenia in pregnancy: a retrospective study
This study aims to investigate pregnant women with severe thrombocytopenia (platelet count (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Nonimmune-acquired factor XIII deficiency: a cause of high volume and delayed postoperative hemorrhage
Factor XIII (FXIII) levels may decrease because of surgical consumption. Acquired FXIII deficiency could be a cause of postoperative hemorrhage usually underdiagnosed in clinical practice. To determine the diagnosis confirmation rate of acquired FXIII deficiency in postsurgical patients with clinical suspicion and to compare the characteristics and evolution of patients with or without FXIII deficiency. We performed a retrospective cohort study, which included 49 inpatients who were attended at our university hospital from 2014 to 2018 with suspicion of acquired FXIII deficiency because of disproportionate postoperative he...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

A novel splicing mutation in F8 causes various aberrant transcripts in a hemophilia A patient and identifies a new transcript from healthy individuals
Hemophilia A is an X-linked hemorrhagic disorder caused by deficiency or dysfunction of the coagulation factor VIII (FVIII), and a great variety of mutations in the factor VIII gene (F8) are identified. We aimed to identify the genetic defects of the F8 gene in a Chinese patient with moderate hemophilia A. We have identified a novel intronic variant in the hemophilia A patient by DNA sequence analysis, cDNA sequencing, and TA clone sequencing. An intronic variant, c.5816-1G>A, was identified and the cDNA sequencing confirmed the pathogenicity of the transition. TA clone sequencing showed that the splicing mutation produ...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Use of direct oral anticoagulants in cerebral venous thrombosis: a systematic review
We are here to review the efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of Cerebral Venous Thrombosis (CVT). A search strategy was developed with a research librarian. All published articles including trials, studies, case series, and case reports were reviewed from NCBI/PubMed up to May 2019 by two independent reviewers. A total of 11 studies were identified, which included 70 patients with CVT on DOACs. After 6 months follow-up more than 86.7% of these patients had a good outcome on the Modified Rankin Scale (mRS) of 0--1 at 6 months and no recurrence of venous thromboembolic events (VTE) at ...
Source: Blood Coagulation and Fibrinolysis - November 17, 2020 Category: Hematology Tags: REVIEW ARTICLE Source Type: research

Acquired haemophilia A and late development of secondary autoimmune disorders, evidences from a single-centre observational study
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: LETTERS TO THE EDITOR Source Type: research

Estimation of uncertainty in measurement: interest of short-term Bayesian model as a complement to the conventional approach
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: LETTERS TO THE EDITOR Source Type: research

Outpatient central venous access device insertion in very young children with severe haemophilia
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: LETTERS TO THE EDITOR Source Type: research

Analysis of phenotype and genotype of a family with hereditary coagulation factor V deficiency caused by the compound heterozygous mutations
To analyze the causative gene and the molecular pathogenesis in a pedigree with compound hereditary coagulation factor V deficiency. Routine blood coagulation indexes and factor V antigen (FV:Ag) were detected by the one-stage clotting method and ELISA. Function of the mutant protein was evaluated by the method Calibrated Automated Thrombogram (CAT). The factor V gene was amplified by PCR with direct sequencing. The possible impact of the mutations were analyzed by bioinformatics tools. The proband's factor V activity and FV:Ag were reduced to 3 and 6%. Gene sequencing revealed compound heterozygous mutations c.911G>A (...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: MUTATION REPORT Source Type: research

A rare heterozygous variant in FGB (Fibrinogen Merivale) causing hypofibrinogenemia in a Swedish family
We describe a case of familial hypofibrinogenemia in a Swedish family. The proband is a 27-year-old woman, with a history of significant bleeding diathesis. She was diagnosed with moderate hypofibrinogenemia (0.8 g/l), and genetic screening identified a rare heterozygous missense variant in FGB (c.854G>A, p.Arg285His) (Fibrinogen Merivale) previously described in a New Zealand European family with symptomatic hypofibrinogenemia. The father, sister and brother of the proband also harbored the FGB variant, segregating with hypofibrinogenemia (0.9–1.2 g/l). The proband showed a more severe bleeding phenotype comp...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: CASE REPORT Source Type: research

Deep intronic F8 c.5999-27A>G variant causes exon 19 skipping and leads to moderate hemophilia A
In conclusion, our study suggests that deep intronic F8 c.5999-27A>G variant may be responsible for F8 exon 19 skipping and lead to moderate hemophilia A. Systematic reanalysis of next-generation sequencing data could promote the diagnostic yields. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

‘Pulmonary thrombosis in situ’: risk factors, clinic characteristics and long-term evolution
The objective of the study is to assess risk factors, comorbidities, clinic characteristics and long-term evolution of patients with pulmonary embolism in the absence of an identified source. Retrospective study of 280 patients with pulmonary embolism, 190 pulmonary embolisms with DVT group and 90 (32%) pulmonary embolism without DVT (DNPE group), admitted to an Internal Medicine Department of a tertiary hospital from January 2012 to December 2015. In the DNPE group, segmental and subsegmental arteries were more frequently affected (P = 0.01). As compared with pulmonary embolisms with DVT group: older age, female sex, ...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

System performance evaluation of the cobas t 711 and cobas t 511 coagulation analyzers in routine laboratory settings
This study aimed to investigate the analytical performance, system functionality, practicability, consistency and throughput of two new automated coagulation analyzers in routine laboratory practice. Real-world settings were simulated in three major European hemostasis laboratories and multiple assays were performed in anonymized plasma samples in parallel with routine clinical practice on the cobas t 711 (high-throughput) and cobas t 511 (mid-throughput) analyzers using activated partial thromboplastin time (aPTT), aPTT Lupus, aPTT Screen, Antithrombin (AT), d-Dimer, Fibrinogen, Prothrombin Time (PT)-derived Fibrinogen, P...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Postpartum bleeding in women with inherited bleeding disorders: a matched cohort study
Women with inherited bleeding disorders (IBDs) are reported to have higher rates of primary and secondary postpartum haemorrhage (PPH), even with optimal haemostatic management. We evaluated whether women with IBD have higher odds of PPH compared with those without, when controlled for mode of delivery with a control group of women without IBDs. The obstetric experiences and outcomes of all women with IBD delivering at a tertiary centre between 2008 and 2017, were compared with matched controls (1 : 1). Obstetric care was provided according to national guidelines to both women with IBD and controls. Primary PPH was def...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

The value of brain natriuretic peptide in the prosthetic valve thrombosis
We aimed to investigate how prosthetic valve thrombosis (PVT) affects brain natriuretic peptide (BNP) levels and how BNP changes following thrombolytic therapy. The study included 70 consecutive patients with left-sided mechanical PVT who received thrombolytic therapy. The patients were divided into two groups, namely obstructive thrombus (n = 42) and nonobstructive thrombus (NOT, n = 28). BNP levels of patients were assessed before and after thrombolytic therapy. BNP levels were higher in obstructive thrombus group than NOT group in whole study population, in patients with mitral PVT and in patients with aortic PV...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Use of recombinant activated factor VII for uncontrolled bleeding in a haematology/oncology paediatric ICU cohort
Bleeding among critically ill paediatric haematology/oncology (CIPHO) patients leads to significant morbidity and mortality. Recombinant activated factor VII (rFVIIa) has shown some benefits in previous reported off-label use when conventional therapies have failed. However, data in CIPHO are lacking. We retrospectively studied (2006–2014) the efficacy and outcomes in CIPHO patients younger than 21 years who received at least one rFVIIa dose for bleeding in the ICU. Of 39 patients, the majority had leukaemia (59%), bone marrow transplantation (77%) and a life-threatening bleed (80%) with most common site being pulmon...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Risk of recurrent venous thromboembolism related to prior risk situations: re-evaluation of a cohort study with a longer follow-up
We reported that patients without prior risk situation for VTE had an incidence rate ratio (IRR) three times higher when compared with those with this history. The aim of this study was to re-evaluate the cohort, with a longer follow-up and evaluated the association between the absence of a prior risk situation for VTE with an increased risk for recurrence. A total of 289 patients with a previous VTE were followed for 116 months. Patients were advised to attend the outpatients’ clinic in case of suspected VTE recurrence. Incidence rates of recurrent thrombotic events were calculated as the number of events over the a...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Current methods of measuring platelet activity: pros and cons
This article provides the reader with a rapid comparison of the different systems used to study platelets activities. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: REVIEW ARTICLES Source Type: research

Platelets parameters in septic shock: clinical usefulness and prognostic value
Septic shock is a common cause of admission in the ICUs. Despite tremendous improvement in the management modalities, mortality remains high. Early diagnosis and prompt resuscitation are required to improve prognosis. Therefore, identifying a biomarker that could reveal the sepsis at its earlier stage is of paramount importance. In this regards, platelet parameters, such as mean platelet volume, immature platelet fraction and platelet-derived microparticles have been investigated as possible sepsis biomarkers. In fact, haemostasis disturbances are one of the hallmark of septic shock where platelets play a pivotal role in o...
Source: Blood Coagulation and Fibrinolysis - October 1, 2020 Category: Hematology Tags: REVIEW ARTICLES Source Type: research

An acquired prekallikrein deficiency can be diagnosed only after a sure exclusion of a congenital condition
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: LETTER TO THE EDITOR Source Type: research

Efficacy and safety of eltrombopag during conception and first trimester of pregnancy in a case of refractory severe immune thrombocytopenia
We describe the case of a woman with refractory ITP who took eltrombopag during conception and first trimester of pregnancy. No fetal or maternal complications were reported. Moreover, the patient remained in complete response after delivery despite therapy discontinuation. The analysis of this case and the revision of the available literature suggest that the use of TPO-RAs, thanks to their short time to response, may be effective and feasible during the first trimester of pregnancy, even if not yet recommended by current guidelines. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: CASE REPORTS Source Type: research

Successful treatment of a massive sinus thrombosis in a Chinese woman with antithrombin III deficiency: a case report and review of the literature
We presented a 31-year-old Chinese woman patient who had a family history of AT III deficiency admitted to our hospital. She had a history of pulmonary embolism. She took rivaroxaban for a long time to prevent thrombosis. After giving birth, she stopped taking the medication for half a year and suffered from drug withdrawal symptoms. Four months after drug withdrawal, she suddenly fell into a coma. After diagnosis, it was found to be caused by a subarachnoid hemorrhage. Finally, she was diagnosed with sagittal and transverse sinus thrombosis. After treatment with mechanical thrombectomy, she fully recovered. In sum, we con...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: CASE REPORTS Source Type: research

A case-report of two patients with hereditary protein S deficiency treated by rivaroxaban
Hereditary protein S deficiency is an autosomal dominant disorder associated with a high risk of venous thromboembolism (VTE) and usually results from mutations of PROS1. Historically heparin and warfarin have been applied as recommended treatment of VTE. Recent researches showed that rivaroxaban provided more consistent and predictable anticoagulation than warfarin. However, it is unknown whether rivaroxaban is effective for the treatment of VTE in patients with thrombophilia, including protein S deficiency, due to lack of evidence. Here, we report two cases of recurrent VTE in two patients with hereditary protein S defic...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: CASE REPORTS Source Type: research

Cranberry supplementation as a cause of major intraoperative bleeding during vascular surgery due to aspirin-like platelet inhibition
We report severe excessive bleeding at initiation of vascular surgery in a 74-year-old woman with thoracoabdominal aortic aneurysm undergoing thoracic endovascular aortic repair. After extensive workup, bleeding cause was determined to be an aspirin-like effect from supplemental cranberry intake. After asking the patient to stop cranberry consumption, the aspirin-like effect ceased, and the patient underwent successful thoracic endovascular aortic repair. Cranberry consumption may create an aspirin-like effect that increases risk of bleeding. Providers should be aware of potential adverse effects of cranberries on platelet...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: CASE REPORTS Source Type: research

Hemophilia A and von Willebrand deficiency: therapeutic implications
Hemophilia A is an X-linked bleeding disorder caused by a deficiency of factor VIII. Depending on the factor VIII activity in patient's plasma, we can have three different forms of hemophilia A: mild (5–40 IU/dl), moderate (1–5 IU/dl) and severe ( (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: CASE REPORTS Source Type: research

Interaction of glycated and acetylated human α2-antiplasmin with fibrin clots
In type 2 diabetes mellitus (T2DM), increased α2-antiplasmin incorporation in fibrin and impaired fibrinolysis have been reported. Acetylsalicylic acid (ASA), used in cardiovascular prevention, modulates fibrinolysis and exerts weaker therapeutic effect in this disease. We investigated how glycation and acetylation of α2-antiplasmin affects its interaction with fibrin. Using surface plasmon resonance, we analyzed fibrin binding by α2-antiplasmin incubated with no β-D-glucose or ASA (control); incubated with β-D-glucose (5, 10, 50 mmol/l); (3) incubated with 1.6 mmol/l acetylsalicylic acid (A...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

HJHS 2.1 and HEAD-US assessment in the hemophilic joints: How do their findings compare?
In hemophilic patients methods are needed to better diagnose joint damage early, so that treatments can be adjusted to slow the progression of hemophilic arthropathy. The aim of this study is to investigate the relationship between the Hemophilia Joint Health Score version 2.1 (HJHS 2.1) and hemophilia early arthropathy detection with ultrasound (HEAD-US) scales, as well as each of their individual items, to better understand the value each provides on the joint condition of patients with hemophilia. The study included data from patients with hemophilia older than 16 years of age, who attended a routine check-up. HJHS 2.1 ...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

Are Iranian patients with von Willebrand disease type 2N properly differentiated from hemophilia A and do they receive appropriate treatment?
This study also emphasized the need for inclusion of the VWF:FVIIIB in suspected hemophilia A to achieve an optimal treatment strategy. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research

The association between plasminogen activator inhibitor type-1 and clinical outcome in paediatric sepsis
Acute phase protein plasminogen activator inhibitor type-1 (PAI-1) is a key element in fibrinolysis inhibition in sepsis-induced disseminated intravascular coagulation (DIC). Elevated PAI-1 level is related to worse outcome in sepsis. The aim of this study was to investigate the relationship between plasma PAI-1 level and clinical outcome in children with sepsis. A total of 35 children with sepsis were enrolled into this prospective study. Plasma PAI-1 was measured on day-1 and day-4. Systemic coagulation profile was measured on day-4. Individuals were followed up until 28 days. The mean PAI-1 from day-1 to day-4 in overt ...
Source: Blood Coagulation and Fibrinolysis - August 1, 2020 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research