A novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum
CONCLUSIONS: The resulting clot contraction dynamics based on the expulsion of FITC-albumin can be quantified using a number of kinetic parameters as well as a phase kinetics analysis. The advantages and drawbacks of the new technique are discussed.PMID:38401713 | DOI:10.1016/j.jtha.2024.02.012 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 24, 2024 Category: Hematology Authors: Alina D Peshkova John W Weisel Rustem I Litvinov Source Type: research
A novel technique to quantify the kinetics of blood clot contraction based on the expulsion of fluorescently labeled albumin into serum
CONCLUSIONS: The resulting clot contraction dynamics based on the expulsion of FITC-albumin can be quantified using a number of kinetic parameters as well as a phase kinetics analysis. The advantages and drawbacks of the new technique are discussed.PMID:38401713 | DOI:10.1016/j.jtha.2024.02.012 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 24, 2024 Category: Hematology Authors: Alina D Peshkova John W Weisel Rustem I Litvinov Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of academic research consortium for high bleeding risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
Association between the number of Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria and clinical outcomes in patients with acute coronary syndrome
CONCLUSIONS: ARC-HBR score was independently associated with an increased risk of MACE in patients with ACS after an emergent PCI. Moreover, it had a similar diagnostic ability for predicting MACE within two years compared to the CADILLAC risk score.PMID:36682715 | DOI:10.1016/j.jjcc.2023.01.003 (Source: Journal of Cardiology)
Source: Journal of Cardiology - January 22, 2023 Category: Cardiology Authors: Hirokazu Shimono Akihiro Tokushige Daisuke Kanda Ayaka Ohno Masao Hayashi Mana Fukuyado Mitsumasa Akao Mariko Kawasoe Ryo Arikawa Hideaki Otsuji Hideto Chaen Hideki Okui Naoya Oketani Mitsuru Ohishi Source Type: research
An Updated Review on Glycoprotein IIb/IIIa Inhibitors as Antiplatelet Agents: Basic and Clinical Perspectives
AbstractThe glycoprotein (GP) IIb/IIIa receptor is found integrin present in platelet aggregations. GP IIb/IIIa antagonists interfere with platelet cross-linking and platelet-derived thrombus formation through the competition with fibrinogen and von Willebrand factor. Currently, three parenteral GP IIb/IIIa competitors (tirofiban, eptifibatide, and abciximab) are approved for clinical use in patients affected by percutaneous coronary interventions (PCI) in the location of acute coronary syndrome (ACS). GP IIb/IIIa antagonists have their mechanism of action in platelet aggregation prevention, distal thromboembolism, and thr...
Source: High Blood Pressure and Cardiovascular Prevention - January 13, 2023 Category: Cardiology Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research
