[Reports] Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression
In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4+ T cell counts (
Source: Science Translational Medicine - March 18, 2020 Category: Biomedical Science Authors: Real, F., Capron, C., Sennepin, A., Arrigucci, R., Zhu, A., Sannier, G., Zheng, J., Xu, L., Masse, J.-M., Greffe, S., Cazabat, M., Donoso, M., Delobel, P., Izopet, J., Eugenin, E., Gennaro, M. L., Rouveix, E., Cramer Borde, E., Bomsel, M. Tags: Reports Source Type: research

Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: Contemporaneous Portuguese cross-sectional data
ConclusionsIn 2016, according to data from these national registries, almost all patients with STEMI were treated with aspirin and 76% with dual antiplatelet agents, mostly clopidogrel. GP IIb/IIIa inhibitors were used in few patients, and UFH was the most prevalent parenteral anticoagulant drug.ResumoIntroduçãoO tratamento do enfarte agudo do miocárdio com elevação do segment ST (EAMCSST) baseia-se na ativação da via verde coronária, na administração de terapêutica médica adjuvante e na reperfusão através de angioplastia prim&...
Source: Revista Portuguesa de Cardiologia - February 21, 2020 Category: Cardiology Source Type: research

TEG ®6s system measures the contributions of both platelet count and platelet function to clot formation at the site-of-care.
TEG®6s system measures the contributions of both platelet count and platelet function to clot formation at the site-of-care. Platelets. 2019 Dec 26;:1-7 Authors: Dias JD, Lopez-Espina CG, Bliden K, Gurbel P, Hartmann J, Achneck HE Abstract Knowledge of platelet count and function is key to ensuring appropriate hemostatic management. We hypothesized that the novel, portable TEG®6s coagulation assessment system could evaluate the contribution of both platelet count and function to clot formation. Whole-blood samples with variable platelet counts were prepared from healthy volunteers. Platelet fun...
Source: Platelets - December 28, 2019 Category: Hematology Tags: Platelets Source Type: research

Routine Glycoprotein IIb/IIIa Inhibitor Therapy in ST-Segment Elevation Myocardial Infarction: A Meta-analysis
This study aimed to evaluate routine GPI use in STEMI treated with primary percutaneous coronary intervention.MethodsOnline databases were searched for randomized controlled trials of routine GPI vs control therapy in STEMI. Data from retrieved studies were abstracted and evaluated in a comprehensive meta-analysis. Twenty-one randomized controlled trials with 8585 patients were included: 10 trials randomized tirofiban, 9 abciximab, 1 trial eptifibatide, and 1 trial used abciximab+tirofiban; only 1 trial used dual antiplatelet therapy with prasugrel/ticagrelor.ResultsRoutine GPI use was associated with a significant reducti...
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: A narrative review
This article reviews the major pharmacologic features of, and clinical evidence on, adjuvant medical therapy in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. These drugs include oral antiplatelets (aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor), intravenous antiplatelet agents (the P2Y12 inhibitor cangrelor, GP IIb/IIIa inhibitors such as abciximab, eptifibatide and tirofiban), and intravenous anticoagulant agents (unfractionated heparin, low molecular weight heparin and bivalirudin).ResumoNeste artigo foram analisadas as princ...
Source: Revista Portuguesa de Cardiologia - June 13, 2019 Category: Cardiology Source Type: research

Routine Glycoprotein IIb/IIIa Inhibitor Therapy in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis
This study aimed to evaluate routine GPI use in STEMI treated with primary PCI.MethodsOnline databases were searched for randomized controlled trials (RCTs) of routine GPI vs. control therapy in STEMI. Data from retrieved studies were abstracted and evaluated in a comprehensive meta-analysis.Twenty-one RCTs with 8,585 patients were included: ten trials randomized tirofiban (T), nine abciximab (A), one eptifibatide (E), one trial used A+T; only one trial used DAPT with prasugrel/ticagrelor.ResultsRoutine GPI were associated with a significant reduction in all-cause mortality at 30 days (2.4% (GPI) vs. 3.2%; risk ratio (RR) ...
Source: Canadian Journal of Cardiology - May 8, 2019 Category: Cardiology Source Type: research

Perioperative Bridging With Glycoprotein IIb/IIIa Inhibitors Versus Cangrelor: Balancing Efficacy and Safety.
CONCLUSIONS: Eptifibatide, tirofiban, and cangrelor are preferred over abciximab as a perioperative bridge. The choice of agent should be tailored to clinical characteristics of the patient and institutional acquisition costs. PMID: 30646761 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 16, 2019 Category: Drugs & Pharmacology Authors: Van Tuyl JS, Newsome AS, Hollis IB Tags: Ann Pharmacother Source Type: research

Pipeline Diameter Significantly Impacts the Long-Term Fate of Jailed Side Branches during Treatment of Intracranial Aneurysms [INTERVENTIONAL]
CONCLUSIONS: A smaller Pipeline Embolization Device diameter is associated with delayed side branch stenosis/occlusion following Pipeline Embolization Device treatment, likely due to the higher metal density of smaller caliber devices. Although hemodynamic factors, including the potential for collateral flow, are still paramount in determining the fate of covered side branches, the amount of metal coverage at the side branch orifice also plays an important role. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - December 14, 2018 Category: Radiology Authors: Miller, T. R., Kole, M. J., Le, E. J., Cannarsa, G., Jones, S., Wessell, A. P., Jindal, G., Aldrich, E. F., Simard, J. M., Gandhi, D. Tags: INTERVENTIONAL Source Type: research

The Interaction of Cross-Linked Fibrin Fragment D-Dimer with {alpha}IIb{beta}3 Requires Receptor Activation, Occurs at Sites Other Than the {gamma}-404-411 Sequence, and Contributes to Clot Retraction
Background: The interaction between the fibrinogen (fbg) -chain sequence 404-411 and the 'RGD pocket' formed by αIIb and β3 plays a major role in platelet (P) aggregation. It requires activation of αIIbβ3 when fbg is in solution, but not when fbg is immobilized. Less is known about the interaction of Ps with cross-linked fibrin, which presumably is the dominant form of fibrin(ogen) in human thrombi and the form that participates in clot retraction. αIIbβ3 is required for clot retraction since it is decreased or absent in Glanzmann thrombasthenia patients who lack a functional receptor. Para...
Source: Blood - November 21, 2018 Category: Hematology Authors: Zafar, H., Li, J., Buitrago, C., Nesic, D., Coller, B. S. Tags: 301. Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion, Activation, and Biochemistry: Platelet Signaling and Interaction with the Microenvironment Source Type: research

Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of RUC-4 Succinate, a Novel {alpha}IIb{beta}3 Pure Antagonist for First Point of Contact Treatment of ST Segment Elevated Myocardial Infarction (STEMI)
We are developing the novel αIIbβ3 pure antagonist, RUC-4, for first point of contact treatment of ST Segment Elevated Myocardial Infarction (STEMI) in combination with aspirin. We have chosen the subcutaneous (SC) route to facilitate its delivery by ambulance and emergency room personnel, and potentially by self-administration. In preparation for initiating human studies, we have conducted preclinical studies of: 1. the pharmacokinetics (PK) and pharmacodynamics (PD) of RUC-4 succinate administered IV, IM, and SC to non-human primates (NHP); 2. the impact of in vitro aspirin on the RUC-4 IC50 in human platelet-...
Source: Blood - November 21, 2018 Category: Hematology Authors: Vootukuri, S., Li, J., Nedelman, M., Babayeva, M., Coller, B. S. Tags: 332. Antithrombotic Therapy: Poster I Source Type: research

Targeting {beta}3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone
Integrin αIIbβ3 plays key roles in thrombosis and hemostasis primarily through mediating platelet adhesion and aggregation. We recently reported that the active site of thiol-isomerase enzymes, CXXC motif, is expressed twice within the plexin-semaphorin-integrin (PSI) domain across all integrins and species, and the PSI domain of β3 integrin possesses endogenous thiol-isomerase activity, which may be a novel target for anti-thrombotic therapy (Blood, 2017).We developed four mouse anti-mouse β3 integrin PSI domain monoclonal antibodies (mAbs). These mAbs cross-react with β3 PSI domains of human, mo...
Source: Blood - November 21, 2018 Category: Hematology Authors: Stratton, T. W., Zhu, G., Wang, Y., Chen, P., Neves, M. A. D., Gallant, R. C., Norris, P. A. A., Freedman, J. J., Ni, H. Tags: 332. Antithrombotic Therapy: Poster I Source Type: research

Fibrinolysis of Contracted Blood Clots Depends on Whether Plasminogen Activator Acts from inside or Outside
Fibrinolysis involves the dissolution of polymeric fibrin networks that is required to restore blood flow through vessels obstructed by clots and thrombi. The efficiency of lysis depends on the susceptibility of fibrin to enzymatic digestion, which is governed by the structure and spatial organization of fibrin fibers as well as porosity and composition of the clot. Platelet-driven clot contraction results in compaction of the erythrocytes into the core of the clot, effectively reducing the permeability of the clot, and influences fibrin network structure. We have shown that clot contraction is reduced in blood from patien...
Source: Blood - November 21, 2018 Category: Hematology Authors: Tutwiler, V., Peshkova, A. D., Le Minh, G., Zaitsev, S., Litvinov, R. I., Cines, D. B., Weisel, J. W. Tags: 321. Blood Coagulation and Fibrinolytic Factors: Poster III Source Type: research

Intracoronary or intravenous abciximab after aspiration thrombectomy in patients with STEMI undergoing primary percutaneous coronary intervention.
CONCLUSIONS: IC versus IV abciximab did not enhance myocardial reperfusion in non-selected patients with STEMI undergoing primary PCI after aspiration thrombectomy had successfully been performed. PMID: 30460974 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - November 20, 2018 Category: Cardiology Authors: Bedjaoui A, Allal K, Lounes MS, Belhadi CE, Mekarnia A, Sediki S, Kara M, Azaza A, Monsuez JJ, Benkhedda S Tags: Cardiovasc J Afr Source Type: research

Intracoronary Tenecteplase versus Abciximab as Adjunctive Treatment during Primary Percutaneous Coronary Intervention in Patients with Anterior Myocardial Infarction.
CONCLUSIONS: Intracoronary administration of tenecteplase did not reduce infarct size compared to abciximab in STEMI patients undergoing PPCI. Tenecteplase exhibited poorer myocardial reperfusion and might be associated with increased subacute stent thrombosis. PMID: 30418157 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - November 13, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Use of Antiplatelet Agents in the Neurosurgical Patient
This article presents the relevant data supporting the use of antiplatelet agents in vascular neurosurgery and recommendations based on the described studies. (Source: Neurosurgery Clinics of North America)
Source: Neurosurgery Clinics of North America - September 15, 2018 Category: Neurosurgery Authors: Amanda S. Zakeri, Shahid M. Nimjee Source Type: research

Massive stent thrombosis during active ulcerative colitis: the tricky balance between manifest hemorrhagic and concealed thrombotic risk
We report the case of a 70-year-old man who presented with ST elevation myocardial infarction during the active phase of ulcerative colitis (UC). Because of the ongoing hematochezia, after successful revascularization of the culprit vessel, the patient was medicated with Clopidogrel, in place of one of the more powerful new oral P2Y12 inhibitors that currently represent the gold standard therapy. Few days later a second elective percutaneous coronary intervention (PCI) on a non-culprit vessel ensued in a life-threatening early massive stent thrombosis involving the left main. During and after emergency PCI antiplatelet the...
Source: Clinical and Experimental Medicine - August 22, 2018 Category: Research Source Type: research

Leu33Pro (PlA) polymorphism of integrin beta3 modulates platelet Src pY418 and focal adhesion kinase pY397 phosphorylation in response to abnormally high shear stress
Conclusion Taken together, our data indicates an important role of αIIbβ3 and shows that Leu33Pro polymorphism modulates the integrin-mediated Src and FAK signaling in platelets in response to shear stress. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - August 17, 2018 Category: Hematology Tags: Original Articles Source Type: research

Flow-diverter Stents for Internal Carotid Artery Reconstruction Following Spontaneous Dissection: A  Technical Report
ConclusionReconstruction of the ICA as a  rescue strategy for extracranial carotid dissection using flow-diverter stents is feasible and was performed without adverse events in this small series. (Source: Clinical Neuroradiology)
Source: Clinical Neuroradiology - August 13, 2018 Category: Neurology Source Type: research

Comparison of different microscopy approaches to quantification of inhibitory effect on thrombus formation under flow conditions by the example of adenosine receptor agonist HE-NECA
DiscussionWe conclude that wide-field imaging provides reliable qualitative data on an inhibitory effect on thrombus formation, despite differences which can emerge from various approaches to image analysis. However, quantitative evaluation and comparison of the efficacy of inhibitors on the basis of total area occupied by thrombi obtained by wide-field microscopy should be made with caution. To obtain a reliable, quantitative assessment of the effect of a tested compound on thrombus structure the use of confocal microscopy is inevitable. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 20, 2018 Category: Drugs & Pharmacology Source Type: research

What are the effects of the guidelines-recommended treatments of myocardial infarction on the secretion of pro- and anti-inflammatory cytokins in an in vitro murin inflammatory model?
ConclusionAspirin, abciximab and unfractionned heparin have an important anti-IL-1β effect, reducing its secretion. This could explain the lack of efficacy of the specific anti-IL-1β treatments during the acute phase of myocardial infarction. These results should be confirmed using an in vivo murin model and a human in vitro model. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 10, 2018 Category: Cardiology Source Type: research

Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution
Publication date: July 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 1Author(s): Andreas Koster, Michiel Morshuis, Ingvild Birschmann (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 10, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

What are the effects of the guidelines-recommended treatments of myocardial infarction on the secretion of pro- and anti-inflammatory cytokins in an in vitro murin inflammatory model?
ConclusionAspirin, abciximab and unfractionned heparin have an important anti-IL-1β effect, reducing its secretion. This could explain the lack of efficacy of the specific anti-IL-1β treatments during the acute phase of myocardial infarction. These results should be confirmed using an in vivo murin model and a human in vitro model. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 5, 2018 Category: Cardiology Source Type: research

Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution
Publication date: July 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 1Author(s): Andreas Koster, Michiel Morshuis, Ingvild Birschmann (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 5, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Active Reperfusion Hemorrhage during Thrombectomy: Angiographic Findings and Real-Time Correlation with the CT “Spot Sign”
Conclusions: Active reperfusion hemorrhage involving perforator arteries was observed to correlate with the CT “spot sign” and to be associated with poor outcomes.Intervent Neurol 2018;7:370 –377 (Source: Interventional Neurology)
Source: Interventional Neurology - June 8, 2018 Category: Neurology Source Type: research

Risk Scoring System to Assess Outcomes in Patients Treated with Contemporary Guideline-Adherent Optimal Therapies after Acute Myocardial Infarction.
CONCLUSIONS: The KorMI system would be a useful tool for predicting outcomes in survivors treated with guideline-adherent optimal therapies after AMI. PMID: 29856143 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - June 3, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Pipeline Embolization for Salvage Treatment of Previously Stented Residual and Recurrent Cerebral Aneurysms
Conclusions: Salvage flow diversion for previously stented aneurysms is technically challenging but offers good prospects of aneurysm obliteration with acceptable complication rates.Intervent Neurol 2018;7:359 –369 (Source: Interventional Neurology)
Source: Interventional Neurology - June 1, 2018 Category: Neurology Source Type: research

Tirofiban Positively Regulates β1 Integrin and Favours Endothelial Cell Growth on Polylactic Acid Biopolymer Vascular Scaffold (BVS)
AbstractAn unexpectedly high incidence of thrombosis in patients that received the polylactic acid bioresorbable vascular scaffold (BVS) suggests a delayed/incomplete endothelial repair with this stent. The anti-platelet agent tirofiban stimulates endothelial cell migration and proliferation, mediated by VEGF production. We investigated the tirofiban effect on the migration and adhesion of endothelial cells to BVS, in vitro. We performed human umbilical endothelial cell (HUVEC) cultures in the presence of BVS. Tirofiban, similarly to VEGF, increased the ability of HUVEC to grow on the vascular scaffold, compared to unstimu...
Source: Journal of Cardiovascular Translational Research - April 25, 2018 Category: Cardiology Source Type: research

A comparison of intracoronary treatment strategies for thrombus burden removal during primary percutaneous coronary intervention: a COCTAIL II substudy
Conclusion Either local drug delivery of abciximab or manual thrombus aspiration showed comparable results in terms of prestenting and poststenting thrombus burden removal. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - April 10, 2018 Category: Cardiology Tags: Original Research Source Type: research

A Randomized Double-Blind Placebo-Controlled Study Comparing Intracoronary vs Intravenous Abciximab in Patients with ST-Elevation Myocardial Infarction Undergoing Transradial Rescue Percutaneous Coronary Intervention after Failed Thrombolysis
The risk/benefit ratio of glycoprotein IIb/IIIa inhibitors with dual oral antiplatelet therapy after failed thrombolysis and rescue percutaneous coronary intervention (PCI) is unclear. Using a randomized placebo-controlled, double-blind design, we compared intravenous (IV) and intracoronary (IC) abciximab delivery in 74 patients referred for rescue transradial PCI. The primary angiographic endpoints were the final Thrombolysis in Myocardial Infarction (TIMI) flow and myocardial blush grades. Secondary endpoints included acute and 6-month outcomes using angiographic parameters, platelet aggregation parameters, cardiac bioma...
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Olivier F. Bertrand, Éric Larose, Rodrigo Bagur, Frédéric Maes, Valérie Gaudreault, Bernard Noël, Gérald Barbeau, Jean-Pierre Déry, Charles Pirlet, Olivier Costerousse, EArly Discharge after Transradial Stenting of CoronarY Arteries in Acute Myocar Source Type: research

A Randomized Double-Blind Placebo-Controlled Study Comparing Intracoronary Versus Intravenous Abciximab in Patients With ST-Elevation Myocardial Infarction Undergoing Transradial Rescue Percutaneous Coronary Intervention After Failed Thrombolysis
The risk and benefit ratio of glycoprotein IIb/IIIa inhibitors with dual oral antiplatelet therapy after failed thrombolysis and rescue percutaneous coronary intervention (PCI) is unclear. Using a randomized placebo-controlled, double-blind design, we compared intravenous (IV) and intracoronary (IC) abciximab delivery in 74 patients referred for rescue transradial PCI. The primary angiographic end points were the final thrombolysis in myocardial infarction flow and myocardial blush grades. Secondary end points included acute and 6-month outcomes using angiographic parameters, platelet aggregation parameters, cardiac biomar...
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Olivier F. Bertrand, Éric Larose, Rodrigo Bagur, Frédéric Maes, Valérie Gaudreault, Bernard Noël, Gérald Barbeau, Jean-Pierre Déry, Charles Pirlet, Olivier Costerousse, Early Discharge After Transradial Stenting of Coronary Arteries in Acute Myocar Source Type: research

Abciximab (ReoPro) Dosing Strategy for the Management of Acute Intraprocedural Thromboembolic Complications during Pipeline Flow Diversion Treatment of Intracranial Aneurysms
Conclusions: IA ReoPro administration is an effective and safe rescue strategy for the management of acute intraprocedural thromboembolic complications during PED treatment. Using a dosing strategy of either 5-mg increments or a 0.125 mg/kg IA bolus (half cardiac dosing) can provide high rates of recanalization with low rates of hemorrhagic complications and long-term morbidity.Intervent Neurol 2018;7:218 –232 (Source: Interventional Neurology)
Source: Interventional Neurology - February 27, 2018 Category: Neurology Source Type: research

In situ administration of abciximab for thrombus resolution during intracranial bypass surgery: case report.
Abstract Abciximab is a glycoprotein IIb/IIIa receptor antagonist that functions to prevent platelet aggregation, thus reducing thrombus initiation and propagation. It has been widely used during percutaneous endovascular interventions, such as aneurysm coil embolization, angioplasty, atherectomy, and stent placement, as both a preventative and a salvage therapy. The use of abciximab in cardiac and neurosurgical procedures has been associated with a reduced incidence of ischemic complications and a decreased need for repeated intervention. In these settings, abciximab has been delivered transarterially via a micro...
Source: Journal of Neurosurgery - January 19, 2018 Category: Neurosurgery Authors: Buchanan IA, Lee B, Amar AP, Giannotta SL Tags: J Neurosurg Source Type: research

What is the role for Glycoprotein IIb/IIIa inhibitor use in the catheterisation laboratory in the current era?
CONCLUSION: Because of the persistent benefit of GPI in limiting early ischemic complications, especially in higher risk clinical and/or anatomical subsets, and the associated risk of increased bleeding complications, also in contemporary PCI, these agents should currently be used on a selective rather than routine basis, including bail out administration for peri-procedural thrombotic complications. PMID: 29345590 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - January 16, 2018 Category: Drugs & Pharmacology Authors: Rubboli A, Patti G Tags: Curr Vasc Pharmacol Source Type: research

Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution
Publication date: Available online 3 January 2018 Source:The Annals of Thoracic Surgery Author(s): Andreas Koster, Michiel Morshuis, Ingvild Birschmann (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - January 3, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution.
PMID: 29305853 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - January 3, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Koster A, Morshuis M, Birschmann I Tags: Ann Thorac Surg Source Type: research

Bilateral subconjunctival hemorrhage secondary to abciximab use: case report.
In this report, we present the case of a patient with bilateral subconjunctival hemorrhage after receiving abciximab. CASE REPORT: A 40-year-old male patient underwent coronary angiography after acute anterior myocardial infarction and a coronary stent was placed. Abciximab was added to the therapy because of stent thrombosis. Bilateral subconjunctival hemorrhage was observed after the administration of the abciximab treatment. We treated our patient by stopping abciximab and administering artificial tears. CONCLUSİON: For the first time in the literature, we presented the case of a patient with bilateral subcon...
Source: Sao Paulo Medical Journal - December 18, 2017 Category: General Medicine Authors: Kul S, Sayın MR Tags: Sao Paulo Med J Source Type: research

Abciximab/Heparin Therapy for Left Ventricular Assist Device Implantation in Patients With Heparin-Induced Thrombocytopenia
Conclusions This is the first report of a novel abciximab/heparin protocol for LVAD implantation in patients with HIT. The preliminary results suggest the feasibility and safety of this protocol. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - December 10, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Cangrelor or Abciximab as First Choice in Cardiogenic Shock
(Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - December 4, 2017 Category: Cardiology Authors: Lozano, I., Rondan, J., Vegas, J. M., Segovia, E. Tags: To the Editor Source Type: research

Reply: Cangrelor or Abciximab as First Choice in Cardiogenic Shock
(Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - December 4, 2017 Category: Cardiology Authors: Vaduganathan, M., Qamar, A., Badreldin, H. A., Faxon, D. P., Bhatt, D. L. Tags: To the Editor Source Type: research

Early angiographic signs of acute thrombus formation following cerebral aneurysm treatment with the Pipeline embolization device
Conclusions Progressive stagnation or occlusion of covered side branches or target aneurysm are early angiographic signs of acute thrombus formation following PED placement and should prompt immediate treatment with a glycoprotein IIb/IIIa inhibitor. Platelet inhibition testing may help identify those patients who are at an increased risk for this complication. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - October 13, 2017 Category: Neurosurgery Authors: Patel, A., Miller, T. R., Shivashankar, R., Jindal, G., Gandhi, D. Tags: Neuroimaging Source Type: research

Abciximab/Heparin Therapy for Left Ventricular Assist Device Implantation in Patients With Heparin-Induced Thrombocytopenia.
CONCLUSIONS: This is the first report of a novel abciximab/heparin protocol for LVAD implantation in patients with HIT. The preliminary results suggest the feasibility and safety of this protocol. PMID: 28987395 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 4, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Lee CL, Colombo PC, Eisenberger A, Diuguid D, Jennings DL, Han J, Salna MP, Takeda K, Kurlansky PA, Yuzefpolskaya M, Garan AR, Naka Y, Takayama H Tags: Ann Thorac Surg Source Type: research

P2Y12 hyporesponse (PRU>200) is not associated with increased thromboembolic complications in anterior circulation Pipeline
Conclusions P2Y12 hyporesponse (PRU>200) is not associated with increased periprocedural complications in a contemporary series of patients undergoing anterior circulation PED placement. Titration of antiplatelet medications to P2Y12>200 remains unindicated and may increase the risk of hemorrhagic complications. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - September 12, 2017 Category: Neurosurgery Authors: Bender, M. T., Lin, L.-M., Colby, G. P., Lubelski, D., Huang, J., Tamargo, R. J., Coon, A. L. Tags: Clinical neurology Source Type: research

E-022 Low dose eptifibatide for acute icad intervention results in high incidence of acute reocclusion
Conclusion The low dose eptifibatide protocol employed here was safe in that no hemorrhages occurred. However, three of six target vessels re-occluded acutely. While the data are limited, the protocol appears to lack adequate potency to prevent re-occlusion of acutely treated ICAD lesions. Disclosures C. Roels: None. M. Brown: None. R. Janjua: None. D. Heck: 2; C; Stryker. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Roels, C., Brown, M., Janjua, R., Heck, D. Tags: Electronic Poster Abstracts Source Type: research

E-083 Intraarterial and intravenous abciximab for management of acute in-situ thrombosis during pipeline flow diversion of intracranial aneurysms
Conclusions IA and IV ReoPro administration is a effective and safe strategy for the management of acute in-situ thrombosis during PED, with high rates of immediate thrombosis resolution and relatively low rates of hemorrhagic complications and long term morbidity. Disclosures: B. Jiang: None. J. Campos: None. N. Beaty: None. E. Westbroek: None. M. Bender: None. R. Tamargo: None. J. Huang: 2; C; Longeviti. G. Colby: 1; C; Stryker. 2; C; Microvention, Medtronic. A. Coon: 2; C; Medtronic, Microvention, Sequent, Stryker. L. Lin: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Jiang, B., Campos, J., Beaty, N., Westbroek, E., Bender, M., Tamargo, R., Huang, J., Colby, G., Coon, A., Lin, L. Tags: Electronic Poster Abstracts Source Type: research

Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation.
, Siess W Abstract The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused antiplatelet drug, and does not increase bleeding in vivo. We investigated, whether GPVI-Fc added in vitro on top of acetylsalicylic acid (ASA), the P2Y12 antagonist ticagrelor, and the fibrinogen receptor antagonist abciximab alone or in combination would increase inhibition of pla...
Source: Thrombosis and Haemostasis - June 1, 2017 Category: Hematology Authors: Mojica Muñoz AK, Jamasbi J, Degen H, Münch G, Ungerer M, Brandl R, Megens R, Weber C, Lorenz R, Siess W Tags: Thromb Haemost Source Type: research

Impact of shear stress on Src and focal adhesion kinase phosphorylation in fibrinogen-adherent platelets
Shear stress alone can activate platelets resulting in a subsequent platelet aggregation, so-called ‘shear-induced platelet aggregation’. In our work, we analyzed how differently elevated shear stress impacts the Src and focal adhesion kinase (FAK) activation in fibrinogen-adherent human platelets. We detected the extents of Src pY418 and FAK pY397 activations in platelets on immobilized fibrinogen and over BSA under shear conditions. Moreover, we analyzed the role of αIIbβ3 in the shear-induced platelet signaling by performing our experiments in the presence of the αIIbβ3-antagonist Abcix...
Source: Blood Coagulation and Fibrinolysis - May 16, 2017 Category: Hematology Tags: Original Articles Source Type: research

Systemic intravenous abciximab: a novel treatment for acute central retinal artery occlusion?
(Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - May 4, 2017 Category: Opthalmology Authors: Jos é Ferreira Mendes, José Amorim, Gil Calvão‐Santos Tags: Letter to the Editor Source Type: research

Relationship between early administration of abciximab and TIMI flow in STEMI patients undergoing primary angioplasty: findings from a large regional STEMI network
Conclusion: Our results suggest that the use of abciximab, free from pharmacokinetic limits of oral P2Y12 inhibitors, should be considered in STEMI patients with early presentation before primary PCI. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - April 28, 2017 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research