Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research

Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research

Anti-platelet peptides targeting αIIbβ3 outside-in signaling pathway
Curr Protein Pept Sci. 2022 Nov 14. doi: 10.2174/1389203724666221114113413. Online ahead of print.ABSTRACTPlatelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics and clinically approved by US Food and Drug Administration. However, because they interfere with the inside-out signaling of αⅡbβ3, which is required for stable platelet adhesion and aggregation, the applicatio...
Source: Current Protein and Peptide Science - November 16, 2022 Category: Biochemistry Authors: Jialing Wang Xin Xu Source Type: research

P02 Acute intraprocedural thrombosis after flow diverter stent implantation: risk factors and relevance of standard observation time for early detection and management
ConclusionActive surveillance for 30 min after FDS implantation is an effective strategy for early detection and ensuing treatment of AIT, thus preventing secondary sequalae. Hypertension and side branches originating from the aneurysmal sac may increase the risk of AIT.ReferencesThe Original Article Has Not Been Published Yet.Patel A et al. Early Angiographic Signs of Acute Thrombus Formation Following Cerebral Aneurysm Treatment with the Pipeline Embolization Device. J Neurointerv Surg. 2017;9(11):1125–30.Al-Mufti F et al. Bailout Strategies and Complications Associated with the Use of Flow-diverting Stents for Tre...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Hohenstatt, S., Ulfert, C., Herweh, C., Schönenberger, S., Purrucker, J., Bendszus, M., Möhlenbruch, M., Vollherbst, D. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

Efficient delivery of abciximab using mesoporous silica nanoparticles: In-vitro assessment for targeted and improved antithrombotic activity
Colloids Surf B Biointerfaces. 2022 Jul 15;218:112697. doi: 10.1016/j.colsurfb.2022.112697. Online ahead of print.ABSTRACTAbciximab (ABX) is a chimeric monoclonal antibody reported for antithrombotic activity but their delivery remains challenging due to its poor stability in a biological system. The purpose of this research was to deliver ABX on the target efficiently using mesoporous silica nanoparticles (MSN). ABX coated mesoporous silica nanoparticles (MSN-ABX) were formulated and analyzed for particle size, shape, zeta-potential, surface morphology and surface chemistry. XPS analysis confirmed the presence of ABX on t...
Source: Colloids and Surfaces - August 2, 2022 Category: Biotechnology Authors: Vishnu Priya None Vikas Abhishesh Kumar Mehata Dharmendra Jain Sanjeev K Singh Madaswamy S Muthu Source Type: research

Efficient delivery of abciximab using mesoporous silica nanoparticles: In-vitro assessment for targeted and improved antithrombotic activity
Colloids Surf B Biointerfaces. 2022 Jul 15;218:112697. doi: 10.1016/j.colsurfb.2022.112697. Online ahead of print.ABSTRACTAbciximab (ABX) is a chimeric monoclonal antibody reported for antithrombotic activity but their delivery remains challenging due to its poor stability in a biological system. The purpose of this research was to deliver ABX on the target efficiently using mesoporous silica nanoparticles (MSN). ABX coated mesoporous silica nanoparticles (MSN-ABX) were formulated and analyzed for particle size, shape, zeta-potential, surface morphology and surface chemistry. XPS analysis confirmed the presence of ABX on t...
Source: Colloids and Surfaces - August 2, 2022 Category: Biotechnology Authors: Vishnu Priya None Vikas Abhishesh Kumar Mehata Dharmendra Jain Sanjeev K Singh Madaswamy S Muthu Source Type: research

Antiplatelet agents for chronic kidney disease
CONCLUSIONS: Antiplatelet agents probably reduced myocardial infarction and increased major bleeding, but do not appear to reduce all-cause and cardiovascular death among people with CKD and those treated with dialysis. The treatment effects of antiplatelet agents compared with each other are uncertain.PMID:35224730 | DOI:10.1002/14651858.CD008834.pub4 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 28, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Valeria M Saglimbene Marinella Ruospo Mona Razavian Jonathan C Craig Meg J Jardine Angela C Webster Giovanni Fm Strippoli Source Type: research

Antiplatelet agents for chronic kidney disease
CONCLUSIONS: Antiplatelet agents probably reduced myocardial infarction and increased major bleeding, but do not appear to reduce all-cause and cardiovascular death among people with CKD and those treated with dialysis. The treatment effects of antiplatelet agents compared with each other are uncertain.PMID:35224730 | DOI:10.1002/14651858.CD008834.pub4 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 28, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Valeria M Saglimbene Marinella Ruospo Mona Razavian Jonathan C Craig Meg J Jardine Angela C Webster Giovanni Fm Strippoli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research

Ruptured Proximal Anterior Cerebral Artery Aneurysm Treated with Flow Diverter
CONCLUSION: A1 aneurysm endovascular treatment is often challenging. Coiling or assisted coiling is the most frequently employed. Although flow diverter stent (FDS) is a consolidated technique for treating ruptured intracranial blister-like and dissecting aneurysms, its role in treating intracranial saccular ruptured aneurysms has to be elucidated. However, more number of case studies is needed to confirm the efficacy and safety of an FDS in treating ruptured A1 aneurysms.PMID:34859825 | DOI:10.5137/1019-5149.JTN.33423-20.3 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Andrea Giorgianni Gabriele Vinacci Edoardo Agosti Stefano Molinaro Alberto Vito Terrana Federica Casagrande Francesco Alberto Vizzari Fabio Baruzzi Davide Locatelli Source Type: research