Non-liver mRNA Delivery

We describe efforts to reduce clearance by the liver, a key obstacle to the development of non-liver therapies. We then consider recent examples of nanoparticles that have delivered mRNA to non-liver tissues. Finally, we discuss current clinical mRNA programs, focusing on the COVID vaccines and highlighting lessons that may be applied to future mRNA drugs.PMID:34859663 | DOI:10.1021/acs.accounts.1c00601
Source: Cell Research - Category: Cytology Authors: Source Type: research