FDA Grants Orphan Drug Designation to Novel Mesothelioma Treatment

The U.S. Food and Drug Administration has granted orphan drug designation to ONCOFID-P for the treatment of malignant pleural mesothelioma, a step toward another potential therapy option for patients. ONCOFID-P is an innovative drug conjugate already in advanced clinical development for the treatment of invasive bladder cancer. The mesothelioma designation is based on preclinical data showing high antitumor activity in laboratory and mice models. Fidia Farmaceutici, a multinational research company based in Italy, announced the latest FDA designation, which is designed to encourage the development of novel drugs, particularly for rare diseases, and help facilitate the approval process. “I’m quite excited about where we are at, and where this is going,” University of Padua Professor Antonio Rosato, who has led the drug’s development, told The Mesothelioma Center at Asbestos.com. “This represents an important step forward for treatment.” Eliminating Toxic Side Effects The drug combines paclitaxel, a type of chemotherapy also known as Taxol, with hyaluronic acid, a naturally occurring substance produced from bacteria and often used for its cushioning effect with various joint disorders. With paclitaxel, the hyaluronic acid provides binding to specific cancer cells expressing CD44, a molecule involved in proliferation and migration. This binding promotes increased intracellular concentration of the paclitaxel – making...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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ConclusionsIn this study, we showed TEW-7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse-type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
Systematically mapping the mechanical properties of skin and tissue is useful for biomechanics research and disease diagnostics. For example, later stage breast cancer and lymphoma manifest themselves as hard nodes under the skin. Currently, mechanical measurements are done manually, with a sense of touch or a handheld tool. Manual measurements do not provide quantitative information and vary depending on the skill of the practitioner. Research shows that tactile sensors could be more sensitive than a hand. We propose a method that uses our previously developed skin-crawling robots to noninvasively test the mechanical prop...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
New J. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1NJ03533A, PaperLucie Melounkov á, Miriam Syková, Robert Jirásko, Roman Jambor, Radim Havelek, Eva Peterova, Jan Honzicek, Jaromír Vinklárek Two series of heterobimetallic compounds were prepared from the starting complex [cis-L2PtCl2] containing aminophosphine ligand (L = 2,6-iPr2-C6H3-NHPPh2). They cover neutral Pt-Sn complexes [cis-L2PtX(SnCl3)] (X = Cl, SnCl3) and ionic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2021, Advance Article DOI: 10.1039/D1AN00938A, PaperWei Zhang, Ioannis Karagiannidis, Eliane De Santana Van Vliet, Ruoxin Yao, Ellen J. Beswick, Anhong Zhou Raman spectra acquired from a single living cell were analyzed by a machine learning based algorithm and transformed into aggressiveness score, and further paired with gene expression data for correlation analysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Overall, cancer responsible for loss of 1.9 percent of total life years expected in the absence of cancer in transplant recipients
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Gastroenterology, Internal Medicine, Nephrology, Oncology, Pulmonology, Surgery, Journal, Source Type: news
Conclusion3D-CT angiography is useful for the preoperative assessment of vascular anatomical variations of the IMV and IMA for safe intraoperative navigation and prevention of complications during laparoscopy-assisted left-sided colorectal surgery.
Source: Surgery Today - Category: Surgery Source Type: research
AbstractThe aim of this study was to systematically review the feasibility and safety of non-operative management of small bowel obstruction (SBO) in virgin abdomen. A systematic review was performed through December 2019. The primary outcome was the resolution of non-operative management of SBO in virgin abdomen. Secondary outcomes were the etiology of SBO and findings of exploratory laparotomy. Six studies were included in the analysis. Of the 442 patients, 2 with metastatic cancer received palliative care, and the management in 26 was not reported, so these patients were excluded. A total of 414 patients were ultimately...
Source: Surgery Today - Category: Surgery Source Type: research
Oncologists are calling for this year's San Antonio Breast Cancer Symposium to be moved out of Texas in response to the state's new abortion law, and a boycott of in-person attendance if no move happens.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Hematology-Oncology News Source Type: news
Odds are you can’t account for where you were on every one of the 200 days that elapsed from November 23, 2014 to June 11, 2015. But Samantha Cristoforetti can, since she spent them all aboard the International Space Station. Cristoforetti, Italy’s first female astronaut, set what was then a record for single-mission duration by a woman in space—and that achievement was just one in a lifetime of them. A former captain in the Italian Air Force, Cristoforetti won her fighter pilot’s wings in 2006, after earning a Master’s degree in mechanical engineering. She has been awarded the Order of Merit...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Source Type: news
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
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