Nutritional and metabolic regulation of the metabolite Dimethylguanidino Valeric Acid - an early marker of cardiometabolic disease.

We report that a high sucrose diet induced conversion of ADMA exclusively into DMGV (supporting the relationship with sugary beverage intake in humans), while a high-fat diet promoted conversion of ADMA to both DMGV and citrulline. On the contrary, replacing dietary native starch with high fiber-resistant starch increased ADMA concentrations and induced its conversion to citrulline, without altering DMGV concentrations. In a cohort of obese non-diabetic adults, circulating DMGV concentrations increased and ADMA levels decreased in those with either liver or muscle insulin resistance. This was similar to changes in DMGV and ADMA concentrations found in mice fed a high-sucrose diet. Sucrose is a disaccharide of glucose and fructose. Compared with glucose, incubation of hepatocytes with fructose significantly increased DMGV production. Overall, we provide a comprehensive picture of the dietary determinants of DMGV levels and its association with insulin resistance.
PMID: 32663097 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Endocrinology and Metabolism - July 13, 2020 Category: Physiology Authors: Wali JA, Koay YC, Chami J, Wood C, Corcilius L, Payne RJ, Rodionov RN, Birkenfeld AL, Samocha-Bonet D, Simpson SJ, O'Sullivan JF Tags: Am J Physiol Endocrinol Metab Source Type: research