Intermittent metabolic switching (IMS) via fasting: is it for you and how to do it?

Intermittent metabolic switching (IMS) via fasting is getting mainstream, spearheaded by an all-positive NEJM review published on Christmas Day 2019:https://www.nejm.org/doi/full/10.1056/NEJMra1905136The article is ranked at the 99th percentile compared to other NEJM articles as of 01-02-2020,https://www.nejm.org/doi/metrics/10.1056/NEJMra1905136#social_mediaFasting is an example of hormesis. Hormesis is a term used by toxicologists to refer to a biphasic dose –response to an environmental agent: 1. a low dose stimulation or beneficial effect, 2. a high dose inhibitory or toxic effect. In the fields of biology and medicine hormesis is defined as an adaptive response of cells and organisms to a moderate (usually intermittent) stress. Examples include exe rcise, dietary energy restriction and exposures to low doses of certain phytochemicals. Source:https://www.ncbi.nlm.nih.gov/pubmed/18162444Intermittent metabolic switching (IMS) causes beneficial effects via a three-step process, illustrated below.Effects of Fasting, Intermittent metabolic switching (IMS) (click to enlarge the image).Fasting first causes the use of the glucose from the liver as a source of energy, produced via gluconeogenesis from glycogen from the stores in the liver. The glycogen is exhausted after 10-14 hours, then the glucose to ketone switch via ketogenesis is activated. The body fat releases fatty acids which the liver uses to makes ketones. This is illustrated in figure 2 here: https://www.pnas.org/co...
Source: Clinical Cases and Images - Blog - Category: Universities & Medical Training Tags: Fasting Longevity Source Type: blogs