A young F is hyperthermic, delirious, and dry: Fever-induced Brugada? Diphenhydramine toxicity? Tricyclic?

Conclusion of this paper: Fever is a great risk factor for arrhythmia events in Brugada Syndrome patients. Patients with known fever-triggered Brugada syndrome should be surveilled closely during fever and be started on antipyretic therapy as soon as possible.  There are limited data regarding the impact of EP study in BrS patients triggered by fever.  An EP study might be helpful in symptomatic patients (Sroubek et al., 2016) in the presence of spontaneous BrS ECG or drug-induced ECG.The prognostic significance of fever-induced Brugada syndrome.  Heart Rhythm 2016.Eighty-eight asymptomatic patients with fever induced Type 1 Brugada syndrome had a mean age of 45.8  ± 18.7 years and 71.6% (67 of 88) were men. Twenty-one percent (18 of 88) had a family history of sudden cardiac death and 26.4% (14 of 53) carried a pathogenic SCN5A mutation. Drug-challenge was positive in 29 of 36 patients tested (80.6%).The risk of ventricular fibrillation in asymptomatic patients was 0.9%/y (3 of 88, 43.6  ± 37.4 months).Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome.  Heart Rhythm 2018.  In 588 patients with known Brugada syndrome andfirst arrhythmic event, 35 were during fever.  Family history of sudden death,  history of syncope, and spontaneous type 1 Brugada ECG were noted in 17%, 40%, and 71% of patients, respectively. VF was induced at EP study in ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs

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Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
Publication date: Available online 20 January 2020Source: Carbohydrate PolymersAuthor(s): Sheng Xu, Si-Yu Li, Min Zhang, Hong-Yan Zeng, Kun Wu, Xian-Yao Tian, Chao-Rong Chen, Yong PanAbstractAn efficient and bio-based alginate pillared hydrotalcite (SA@LDHs) was fabricated via calcination-reconstruction manner with sodium alginate (SA) and hydrotalcite (LDHs-C), and used as novel flame retardant for polypropylene (PP). The morphologies and combustion properties of SA@LDHs and its hybrid with PP composites (PP/SA@LDHs) had been characterized by SEM, TGA, cone calorimetry, LOI and UL-94 measurements. With 30 wt% loadi...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Increases in the number of cell therapies in the preclinical and clinical phases have prompted the need for reliable and noninvasive assays to validate transplant function in clinical biomanufacturing. We developed a robust characterization methodology composed of quantitative bright-field absorbance microscopy (QBAM) and deep neural networks (DNNs) to noninvasively predict tissue function and cellular donor identity. The methodology was validated using clinical-grade induced pluripotent stem cell–derived retinal pigment epithelial cells (iPSC-RPE). QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The advent of human induced pluripotent stem cells (iPSCs) provided a means for avoiding ethical concerns associated with the use of cells isolated from human embryos. The number of labs now using iPSCs to generate photoreceptor, retinal pigmented epithelial (RPE), and more recently choroidal endothelial cells has grown exponentially. However, for autologous cell replacement to be effective, manufacturing strategies will need to change. Many tasks carried out by hand will need simplifying and automating. In this issue of the JCI, Schaub and colleagues combined quantitative brightfield microscopy and artificial intelligence...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In this study, we report the surface defect formation of annealed poly(pyromellitic dianhydride-co-4,4′-oxydianiline) (PMDA-ODA) film after detaching the film from soda-lime glass via ion migration. The defect was porous and sodium was observed as one of the major impurities in the defect. We propose that these defects form as a result of the ion migration from glass and thermal decomposition of PMDA-ODA. The ions released from glass at a sufficiently high temperature form hydroxide compounds during the floating of the film on water and readily attacks the imide ring at the glass-film interface. The ionic bonds are b...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05830C, PaperLinsen Huang, Liangxing Zhang, Deyu Bao, Xiaoqing Jiang, Junhua Li, Xiaosong Sun The present study focuses on the synthesis and the characterization of ternary photo-catalyst rGO-Sb4O5Cl2-Sb2S3. A series of rGO-Sb4O5Cl2-Sb2S3 samples were synthesized by the ultrasonic assistant chemical co-precipitation method, and the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Ertel KA, Hallam JE, Hillman AR Abstract BACKGROUND: Individuals participating in exercise beyond their level of fitness may be at higher risk for exercise-induced muscle damage, however the impact of training status on muscle damage development is not well understood. The purpose of this study was to measure skeletal muscle damage and soreness after five days of high and low intensity exercise in previously trained and untrained individuals. METHODS: Eighteen males and females (9 trained and 9 untrained) completed five consecutive days of high intensity (HI) exercise and five consecutive days of low i...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Authors: Qadir KJ, Zangana KO Abstract BACKGROUND: Regular physical activity and exercise is the third management for the child with diabetes mellitus after diet regime and insulin therapy. The aim of the study is to evaluate the effect of swimming on glycemic control for a male adolescent with type 1 diabetes mellitus. OBJECTIVE: The study evaluates the effect of swimming on glycemic control for a male adolescent with type 1 diabetes mellitus. METHODS: The quasi-experimental design was conducted on 40 male adolescents with typ1 diabetes, then divided into two groups; study and control groups. 20 adolescent...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Authors: Monte A, Nardello F, Pavei G, Moro S, Festa L, Tarperi C, Schena F, Zamparo P Abstract BACKGROUND: The aim of this study was to determine the influence of spring mass model characteristics (e.g. stiffness) and Achilles tendon proprieties in determining the energy cost of running in half marathon runners. METHODS: Achilles tendon characteristics (i.e. cross sectional area -ATCSA- and resting length - ATL-) were measured on 32 males by means of an ultrasound apparatus the day before a half marathon race. After these measurements the energy cost of running (C) was determined while the subjects run on a tr...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
I am writing in response to the questions posed by Dr  Bihui Zhang. All the procedures reported in the paper were carried out in the office-based endovascular center. It is a lot easier to get hemostasis at the puncture site while using the tibial approach compared with the distal superficial femoral artery or popliteal approach. This increases the sa fety of the procedure being carried out in the office laboratory. We use a hockey-stick ultrasound probe to enter the tibial artery. We believe that the use of this probe has helped us reach 100% success in cannulating the artery.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
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